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Short-term caraway extract administration improves cardiovascular disease risk markers in streptozotocin-induced diabetic rats: a dose-response study.
J Diet Suppl. 2014 Mar; 11(1):30-9.JD

Abstract

OBJECTIVE

This study examined the effects of caraway plant on blood levels of glucose, lipid profile, and C-reactive protein in diabetic rats.

METHODS

Thirty two male Wistar rats were randomly divided into four groups: group 1: nondiabetic control rats, group 2: diabetic rats, group 3, and 4 (caraway treated diabetic groups): each rat was treated with caraway at doses of 1 g/kg in group 3 and 2 g/kg in group 4. Diabetes was induced by a single intraperitoneal injection of 60 mg/kg streptozotocin. Caraway was administered as aqueous extract orally once a day for 3 weeks. Finally, blood samples were collected and fasting blood glucose, serum lipid profile, and C-reactive protein levels were determined. Data were analyzed statistically by one-way Analysis of Variance and considered to be significant when p < .05.

RESULTS

Diabetic rats receiving 1 and 2 g/kg caraway extracts had significantly lower total cholesterol (p = .036 and p = .010, respectively), low-density lipoprotein (p = .001 and p = .002, respectively), non-HDL-C (p = .003 and p = .007, respectively), LDL-C to HDL-C ratio (p = .002) and atherogenic index (p = .001) than that of diabetic control rats. Moreover, there were significant changes in fasting blood glucose in diabetic groups treated with 1 and 2 g/kg caraway extracts (p = .001 and p = .027, respectively) compared with the diabetic control. However, caraway did not have any significant effect on C-reactive protein level in diabetic rats.

CONCLUSION

This study suggests that caraway can exhibit blood glucose and lipid lowering activities in diabetes, without any effect on C-reactive protein level.

Authors+Show Affiliations

1Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24409979

Citation

Sadjadi, Neda Seyed, et al. "Short-term Caraway Extract Administration Improves Cardiovascular Disease Risk Markers in Streptozotocin-induced Diabetic Rats: a Dose-response Study." Journal of Dietary Supplements, vol. 11, no. 1, 2014, pp. 30-9.
Sadjadi NS, Shahi MM, Jalali MT, et al. Short-term caraway extract administration improves cardiovascular disease risk markers in streptozotocin-induced diabetic rats: a dose-response study. J Diet Suppl. 2014;11(1):30-9.
Sadjadi, N. S., Shahi, M. M., Jalali, M. T., & Haidari, F. (2014). Short-term caraway extract administration improves cardiovascular disease risk markers in streptozotocin-induced diabetic rats: a dose-response study. Journal of Dietary Supplements, 11(1), 30-9. https://doi.org/10.3109/19390211.2013.859214
Sadjadi NS, et al. Short-term Caraway Extract Administration Improves Cardiovascular Disease Risk Markers in Streptozotocin-induced Diabetic Rats: a Dose-response Study. J Diet Suppl. 2014;11(1):30-9. PubMed PMID: 24409979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term caraway extract administration improves cardiovascular disease risk markers in streptozotocin-induced diabetic rats: a dose-response study. AU - Sadjadi,Neda Seyed, AU - Shahi,Majid Mohammad, AU - Jalali,Mohammad-Taha, AU - Haidari,Fatemeh, Y1 - 2014/01/10/ PY - 2014/1/14/entrez PY - 2014/1/15/pubmed PY - 2014/10/7/medline SP - 30 EP - 9 JF - Journal of dietary supplements JO - J Diet Suppl VL - 11 IS - 1 N2 - OBJECTIVE: This study examined the effects of caraway plant on blood levels of glucose, lipid profile, and C-reactive protein in diabetic rats. METHODS: Thirty two male Wistar rats were randomly divided into four groups: group 1: nondiabetic control rats, group 2: diabetic rats, group 3, and 4 (caraway treated diabetic groups): each rat was treated with caraway at doses of 1 g/kg in group 3 and 2 g/kg in group 4. Diabetes was induced by a single intraperitoneal injection of 60 mg/kg streptozotocin. Caraway was administered as aqueous extract orally once a day for 3 weeks. Finally, blood samples were collected and fasting blood glucose, serum lipid profile, and C-reactive protein levels were determined. Data were analyzed statistically by one-way Analysis of Variance and considered to be significant when p < .05. RESULTS: Diabetic rats receiving 1 and 2 g/kg caraway extracts had significantly lower total cholesterol (p = .036 and p = .010, respectively), low-density lipoprotein (p = .001 and p = .002, respectively), non-HDL-C (p = .003 and p = .007, respectively), LDL-C to HDL-C ratio (p = .002) and atherogenic index (p = .001) than that of diabetic control rats. Moreover, there were significant changes in fasting blood glucose in diabetic groups treated with 1 and 2 g/kg caraway extracts (p = .001 and p = .027, respectively) compared with the diabetic control. However, caraway did not have any significant effect on C-reactive protein level in diabetic rats. CONCLUSION: This study suggests that caraway can exhibit blood glucose and lipid lowering activities in diabetes, without any effect on C-reactive protein level. SN - 1939-022X UR - https://www.unboundmedicine.com/medline/citation/24409979/Short_term_caraway_extract_administration_improves_cardiovascular_disease_risk_markers_in_streptozotocin_induced_diabetic_rats:_a_dose_response_study_ L2 - https://www.tandfonline.com/doi/full/10.3109/19390211.2013.859214 DB - PRIME DP - Unbound Medicine ER -