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Gender moderates the influence of psychosocial factors and drug use on HAART adherence in the context of HIV and childhood sexual abuse.
AIDS Care. 2014; 26(8):959-67.AC

Abstract

This study aimed to examine gender moderation within a stress and coping model of HIV medication adherence in adults with a history of childhood sexual abuse (CSA). Sequelae of CSA, including negative coping, psychological distress, and drug use, interfere with adherence to highly active antiretroviral treatment (HAART). These obstacles to adherence are likely moderated by gender. Gender may particularly influence the mediational effect of drug use on adherence. Participants included 206 adults living with HIV/AIDS and CSA. Categorical/continuous variable methodology in a structural equation modeling framework was used to test a multigroup model with women and men. Gender significantly moderated several effects in the model. For women, the effect of psychological distress on HAART adherence was mediated by drug use and the effect of drug use on viral load was mediated by HAART adherence. Among men, drug use did not significantly impact adherence. Since gender appears to moderate the effect of drug use on medication adherence, it is particularly important to address drug use within the context of HIV disease management in women with a history of CSA. Further, interventions to increase HAART adherence should take trauma history, gender, and drug abuse into account when assessing efficacy.

Authors+Show Affiliations

a Department of Psychology and Neuroscience , Duke University , Durham , NC , USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24410324

Citation

Wilson, Sarah M., et al. "Gender Moderates the Influence of Psychosocial Factors and Drug Use On HAART Adherence in the Context of HIV and Childhood Sexual Abuse." AIDS Care, vol. 26, no. 8, 2014, pp. 959-67.
Wilson SM, Sikkema KJ, Ranby KW. Gender moderates the influence of psychosocial factors and drug use on HAART adherence in the context of HIV and childhood sexual abuse. AIDS Care. 2014;26(8):959-67.
Wilson, S. M., Sikkema, K. J., & Ranby, K. W. (2014). Gender moderates the influence of psychosocial factors and drug use on HAART adherence in the context of HIV and childhood sexual abuse. AIDS Care, 26(8), 959-67. https://doi.org/10.1080/09540121.2013.873765
Wilson SM, Sikkema KJ, Ranby KW. Gender Moderates the Influence of Psychosocial Factors and Drug Use On HAART Adherence in the Context of HIV and Childhood Sexual Abuse. AIDS Care. 2014;26(8):959-67. PubMed PMID: 24410324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender moderates the influence of psychosocial factors and drug use on HAART adherence in the context of HIV and childhood sexual abuse. AU - Wilson,Sarah M, AU - Sikkema,Kathleen J, AU - Ranby,Krista W, Y1 - 2014/01/13/ PY - 2014/1/14/entrez PY - 2014/1/15/pubmed PY - 2015/5/28/medline KW - HIV KW - childhood sexual abuse KW - drug abuse KW - gender difference KW - medication adherence KW - structural equation modeling SP - 959 EP - 67 JF - AIDS care JO - AIDS Care VL - 26 IS - 8 N2 - This study aimed to examine gender moderation within a stress and coping model of HIV medication adherence in adults with a history of childhood sexual abuse (CSA). Sequelae of CSA, including negative coping, psychological distress, and drug use, interfere with adherence to highly active antiretroviral treatment (HAART). These obstacles to adherence are likely moderated by gender. Gender may particularly influence the mediational effect of drug use on adherence. Participants included 206 adults living with HIV/AIDS and CSA. Categorical/continuous variable methodology in a structural equation modeling framework was used to test a multigroup model with women and men. Gender significantly moderated several effects in the model. For women, the effect of psychological distress on HAART adherence was mediated by drug use and the effect of drug use on viral load was mediated by HAART adherence. Among men, drug use did not significantly impact adherence. Since gender appears to moderate the effect of drug use on medication adherence, it is particularly important to address drug use within the context of HIV disease management in women with a history of CSA. Further, interventions to increase HAART adherence should take trauma history, gender, and drug abuse into account when assessing efficacy. SN - 1360-0451 UR - https://www.unboundmedicine.com/medline/citation/24410324/Gender_moderates_the_influence_of_psychosocial_factors_and_drug_use_on_HAART_adherence_in_the_context_of_HIV_and_childhood_sexual_abuse_ L2 - https://www.tandfonline.com/doi/full/10.1080/09540121.2013.873765 DB - PRIME DP - Unbound Medicine ER -