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Pharmacological approach to overactive bladder and urge urinary incontinence in women: an overview.
Eur J Obstet Gynecol Reprod Biol. 2014 Mar; 174:27-34.EJ

Abstract

Besides life-style changes, electrical stimulation or surgery, pharmacological treatment is becoming the first-choice approach in women suffering from lower urinary tract symptoms (LUTS), including urge urinary incontinence (UUI) and overactive bladder (OAB). Several drugs for the treatment of bladder storage and voiding disorders are currently available and, in the near future, novel compounds with higher specificity for the lower urinary tract receptors will be accessible. This will bring optimization of therapy, reducing side effects and increasing compliance, especially in patients with comorbidities and in women. The purpose of this paper is to give an overview on the pharmacotherapy of two common inter-correlated urological conditions, UUI and OAB. The study was conducted by analyzing and comparing the data of the recent international literature on this topic. Advances in the discovery of pharmacological options have dramatically improved the quality of life of patients affected by incontinence, but further studies are needed to increase the effectiveness and safety of the therapies used in this field.

Authors+Show Affiliations

Department of Gynecology and Obstetrics of San Giovanni di Dio and Ruggi d'Aragona Hospital, University of Salerno, SA, Italy. Electronic address: luciocipullo@hotmail.com.Department of Medicine and Surgery, University of Salerno, SA, Italy.Department of Medicine and Surgery, University of Salerno, SA, Italy.Department of Medicine and Surgery, University of Salerno, SA, Italy.Department of Medicine and Surgery, University of Salerno, SA, Italy.Department of Gynecology and Obstetrics of San Giovanni di Dio and Ruggi d'Aragona Hospital, University of Salerno, SA, Italy.Department of Gynecology and Obstetrics of San Giovanni di Dio and Ruggi d'Aragona Hospital, University of Salerno, SA, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24411952

Citation

Cipullo, Lucio M A., et al. "Pharmacological Approach to Overactive Bladder and Urge Urinary Incontinence in Women: an Overview." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 174, 2014, pp. 27-34.
Cipullo LM, Cosimato C, Filippelli A, et al. Pharmacological approach to overactive bladder and urge urinary incontinence in women: an overview. Eur J Obstet Gynecol Reprod Biol. 2014;174:27-34.
Cipullo, L. M., Cosimato, C., Filippelli, A., Conti, V., Izzo, V., Zullo, F., & Guida, M. (2014). Pharmacological approach to overactive bladder and urge urinary incontinence in women: an overview. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 174, 27-34. https://doi.org/10.1016/j.ejogrb.2013.12.024
Cipullo LM, et al. Pharmacological Approach to Overactive Bladder and Urge Urinary Incontinence in Women: an Overview. Eur J Obstet Gynecol Reprod Biol. 2014;174:27-34. PubMed PMID: 24411952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacological approach to overactive bladder and urge urinary incontinence in women: an overview. AU - Cipullo,Lucio M A, AU - Cosimato,Cosimo, AU - Filippelli,Amelia, AU - Conti,Valeria, AU - Izzo,Viviana, AU - Zullo,Fulvio, AU - Guida,Maurizio, Y1 - 2013/12/26/ PY - 2013/06/10/received PY - 2013/09/21/revised PY - 2013/12/16/accepted PY - 2014/1/14/entrez PY - 2014/1/15/pubmed PY - 2014/11/5/medline KW - Bladder target receptors KW - Overactive bladder KW - Urge urinary incontinence KW - Urological pharmacotherapy SP - 27 EP - 34 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 174 N2 - Besides life-style changes, electrical stimulation or surgery, pharmacological treatment is becoming the first-choice approach in women suffering from lower urinary tract symptoms (LUTS), including urge urinary incontinence (UUI) and overactive bladder (OAB). Several drugs for the treatment of bladder storage and voiding disorders are currently available and, in the near future, novel compounds with higher specificity for the lower urinary tract receptors will be accessible. This will bring optimization of therapy, reducing side effects and increasing compliance, especially in patients with comorbidities and in women. The purpose of this paper is to give an overview on the pharmacotherapy of two common inter-correlated urological conditions, UUI and OAB. The study was conducted by analyzing and comparing the data of the recent international literature on this topic. Advances in the discovery of pharmacological options have dramatically improved the quality of life of patients affected by incontinence, but further studies are needed to increase the effectiveness and safety of the therapies used in this field. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/24411952/Pharmacological_approach_to_overactive_bladder_and_urge_urinary_incontinence_in_women:_an_overview_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(13)00648-9 DB - PRIME DP - Unbound Medicine ER -