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Synthetic cannabinoids: analysis and metabolites.
Life Sci 2014; 97(1):78-90LS

Abstract

Cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds encompassing a wide range of chemical structures, have been developed by scientists with the hope of achieving selectivity toward one or the other of the cannabinoid receptors CB1 and CB2. The goal was to have compounds that could possess high therapeutic activity without many side effects. However, underground laboratories have used the information generated by the scientific community to develop these compounds for illicit use as marijuana substitutes. This chapter reviews the different classes of these "synthetic cannabinoids" with particular emphasis on the methods used for their identification in the herbal products with which they are mixed and identification of their metabolites in biological specimens.

Authors+Show Affiliations

ElSohly Laboratories, Inc., 5 Industrial Park Drive, Oxford, MS 38655, USA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS 38677, USA. Electronic address: melsohly@olemiss.edu.ElSohly Laboratories, Inc., 5 Industrial Park Drive, Oxford, MS 38655, USA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA; Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

24412391

Citation

Elsohly, Mahmoud A., et al. "Synthetic Cannabinoids: Analysis and Metabolites." Life Sciences, vol. 97, no. 1, 2014, pp. 78-90.
Elsohly MA, Gul W, Wanas AS, et al. Synthetic cannabinoids: analysis and metabolites. Life Sci. 2014;97(1):78-90.
Elsohly, M. A., Gul, W., Wanas, A. S., & Radwan, M. M. (2014). Synthetic cannabinoids: analysis and metabolites. Life Sciences, 97(1), pp. 78-90. doi:10.1016/j.lfs.2013.12.212.
Elsohly MA, et al. Synthetic Cannabinoids: Analysis and Metabolites. Life Sci. 2014 Feb 27;97(1):78-90. PubMed PMID: 24412391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthetic cannabinoids: analysis and metabolites. AU - Elsohly,Mahmoud A, AU - Gul,Waseem, AU - Wanas,Amira S, AU - Radwan,Mohamed M, Y1 - 2014/01/08/ PY - 2013/10/21/received PY - 2013/12/24/revised PY - 2013/12/24/accepted PY - 2014/1/14/entrez PY - 2014/1/15/pubmed PY - 2014/4/16/medline KW - Analysis KW - Herbal products KW - Metabolites KW - Synthetic cannabinoids SP - 78 EP - 90 JF - Life sciences JO - Life Sci. VL - 97 IS - 1 N2 - Cannabimimetics (commonly referred to as synthetic cannabinoids), a group of compounds encompassing a wide range of chemical structures, have been developed by scientists with the hope of achieving selectivity toward one or the other of the cannabinoid receptors CB1 and CB2. The goal was to have compounds that could possess high therapeutic activity without many side effects. However, underground laboratories have used the information generated by the scientific community to develop these compounds for illicit use as marijuana substitutes. This chapter reviews the different classes of these "synthetic cannabinoids" with particular emphasis on the methods used for their identification in the herbal products with which they are mixed and identification of their metabolites in biological specimens. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/24412391/Synthetic_cannabinoids:_analysis_and_metabolites_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(14)00007-1 DB - PRIME DP - Unbound Medicine ER -