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Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae).
Food Chem Toxicol. 2014 Mar; 65:374-80.FC

Abstract

Propolis from stingless bees is well known for its biologic properties; however, few studies have demonstrated these effects. Therefore, this study aimed to investigate the chemical composition and antimicrobial, antioxidant and cytotoxic activities of propolis from the stingless bee Melipona orbignyi, found in Mato Grosso do Sul, Brazil. The chemical composition of the ethanol extract of propolis (EEP) indicated the presence of aromatic acids, phenolic compounds, alcohols, terpenes and sugars. The EEP was active against the bacterium Staphylococcus aureus and the fungus Candida albicans. The EEP showed antioxidant activity by scavenging free radicals and inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and primarily necrotic death in K562 erythroleukemia cells. Taken together, these results indicate that propolis from M. orbignyi has therapeutic potential for the treatment and/or prevention of diseases related to microorganism activity, oxidative stress and tumor cell proliferation.

Authors+Show Affiliations

School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Ithaum, Km 12, 79804-970 Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Ithaum, Km 12, 79804-970 Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Ithaum, Km 12, 79804-970 Dourados, MS, Brazil.University Center of Grande Dourados, Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Ithaum, Km 12, 79804-970 Dourados, MS, Brazil.Department of Biophysics, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.Course of Chemistry, State University of Mato Grosso do Sul, Rodovia Dourados Ithaum, Km 12, 79804-970 Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Ithaum, Km 12, 79804-970 Dourados, MS, Brazil.School of Environmental and Biological Science, Federal University of Grande Dourados, Rodovia Dourados Ithaum, Km 12, 79804-970 Dourados, MS, Brazil. Electronic address: edson.lucas@pq.cnpq.br.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24412556

Citation

Campos, Jaqueline Ferreira, et al. "Antimicrobial, Antioxidant and Cytotoxic Activities of Propolis From Melipona Orbignyi (Hymenoptera, Apidae)." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 65, 2014, pp. 374-80.
Campos JF, dos Santos UP, Macorini LF, et al. Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae). Food Chem Toxicol. 2014;65:374-80.
Campos, J. F., dos Santos, U. P., Macorini, L. F., de Melo, A. M., Balestieri, J. B., Paredes-Gamero, E. J., Cardoso, C. A., de Picoli Souza, K., & dos Santos, E. L. (2014). Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae). Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 65, 374-80. https://doi.org/10.1016/j.fct.2014.01.008
Campos JF, et al. Antimicrobial, Antioxidant and Cytotoxic Activities of Propolis From Melipona Orbignyi (Hymenoptera, Apidae). Food Chem Toxicol. 2014;65:374-80. PubMed PMID: 24412556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae). AU - Campos,Jaqueline Ferreira, AU - dos Santos,Uilson Pereira, AU - Macorini,Luis Fernando Benitez, AU - de Melo,Adriana Mary Mestriner Felipe, AU - Balestieri,José Benedito Perrella, AU - Paredes-Gamero,Edgar Julian, AU - Cardoso,Claudia Andrea Lima, AU - de Picoli Souza,Kely, AU - dos Santos,Edson Lucas, Y1 - 2014/01/09/ PY - 2013/10/08/received PY - 2013/12/07/revised PY - 2014/01/02/accepted PY - 2014/1/14/entrez PY - 2014/1/15/pubmed PY - 2014/10/29/medline KW - Anti-tumor activity KW - Hemolysis KW - Lipid peroxidation KW - Necrosis KW - Oxidative stress KW - Stingless bee SP - 374 EP - 80 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 65 N2 - Propolis from stingless bees is well known for its biologic properties; however, few studies have demonstrated these effects. Therefore, this study aimed to investigate the chemical composition and antimicrobial, antioxidant and cytotoxic activities of propolis from the stingless bee Melipona orbignyi, found in Mato Grosso do Sul, Brazil. The chemical composition of the ethanol extract of propolis (EEP) indicated the presence of aromatic acids, phenolic compounds, alcohols, terpenes and sugars. The EEP was active against the bacterium Staphylococcus aureus and the fungus Candida albicans. The EEP showed antioxidant activity by scavenging free radicals and inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and primarily necrotic death in K562 erythroleukemia cells. Taken together, these results indicate that propolis from M. orbignyi has therapeutic potential for the treatment and/or prevention of diseases related to microorganism activity, oxidative stress and tumor cell proliferation. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/24412556/Antimicrobial_antioxidant_and_cytotoxic_activities_of_propolis_from_Melipona_orbignyi__Hymenoptera_Apidae__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(14)00011-8 DB - PRIME DP - Unbound Medicine ER -