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The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia.
Neurosci Lett. 2014 Mar 06; 562:28-33.NL

Abstract

(±)-Tramadol hydrochloride (tramadol) is a widely used analgesic for the treatment of cancer pain and chronic pain. Although many animal studies have shown antinociceptive effects of tramadol in both acute and chronic pain, little is known about the effect of tramadol in putative animal models of fibromyalgia. In this study, we compared the antiallodynic effects of oral administration of tramadol in two kinds of rat chronic pain models, neuropathic pain induced by partial sciatic nerve ligation (PSL) and reserpine-induced myalgia (RIM). In PSL rats, the threshold for responses induced by tactile stimulation with von Frey filaments was significantly decreased seven days after the operation, suggesting that the operation induced tactile allodynia. Orally administered tramadol showed a potent and dose-dependent antiallodynic effect on PSL-induced allodynia. In RIM rats, the threshold was significantly decreased five days after reserpine treatment. Orally administered tramadol also attenuated reserpine-induced tactile allodynia. To explore the mechanism of the antiallodynic effect of tramadol in RIM rats, we investigated the effect of the opioid antagonist naloxone on the tramadol-induced analgesic effect in these rats. The effect of tramadol was partially antagonized by naloxone, suggesting that the opioid receptor is involved at least in part in the antiallodynic effect of tramadol in RIM rats. These data indicate that orally administered tramadol produced improvement in both PSL rats and RIM rats at similar doses and provide evidence that the opioid system is partly involved in the analgesic effect of tramadol in RIM rats.

Authors+Show Affiliations

Research Laboratories, Nippon Shinyaku Co., Ltd., 14, Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan. Electronic address: k.kaneko@po.nippon-shinyaku.co.jp.Research Laboratories, Nippon Shinyaku Co., Ltd., 14, Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.Research Laboratories, Nippon Shinyaku Co., Ltd., 14, Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.Research Laboratories, Nippon Shinyaku Co., Ltd., 14, Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.Research Laboratories, Nippon Shinyaku Co., Ltd., 14, Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.Research Laboratories, Nippon Shinyaku Co., Ltd., 14, Nishinosho-monguchi-cho, Kisshoin, Minami-ku, Kyoto 601-8550, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24412679

Citation

Kaneko, Kumi, et al. "The Analgesic Effect of Tramadol in Animal Models of Neuropathic Pain and Fibromyalgia." Neuroscience Letters, vol. 562, 2014, pp. 28-33.
Kaneko K, Umehara M, Homan T, et al. The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia. Neurosci Lett. 2014;562:28-33.
Kaneko, K., Umehara, M., Homan, T., Okamoto, K., Oka, M., & Oyama, T. (2014). The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia. Neuroscience Letters, 562, 28-33. https://doi.org/10.1016/j.neulet.2014.01.007
Kaneko K, et al. The Analgesic Effect of Tramadol in Animal Models of Neuropathic Pain and Fibromyalgia. Neurosci Lett. 2014 Mar 6;562:28-33. PubMed PMID: 24412679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia. AU - Kaneko,Kumi, AU - Umehara,Masato, AU - Homan,Takashi, AU - Okamoto,Ken, AU - Oka,Michiko, AU - Oyama,Tatsuya, Y1 - 2014/01/09/ PY - 2013/10/07/received PY - 2013/12/17/revised PY - 2014/01/06/accepted PY - 2014/1/14/entrez PY - 2014/1/15/pubmed PY - 2014/11/13/medline KW - Fibromyalgia KW - Naloxone KW - Neuropathic pain KW - Opioid KW - Partial sciatic nerve ligation KW - Reserpine KW - Tramadol SP - 28 EP - 33 JF - Neuroscience letters JO - Neurosci. Lett. VL - 562 N2 - (±)-Tramadol hydrochloride (tramadol) is a widely used analgesic for the treatment of cancer pain and chronic pain. Although many animal studies have shown antinociceptive effects of tramadol in both acute and chronic pain, little is known about the effect of tramadol in putative animal models of fibromyalgia. In this study, we compared the antiallodynic effects of oral administration of tramadol in two kinds of rat chronic pain models, neuropathic pain induced by partial sciatic nerve ligation (PSL) and reserpine-induced myalgia (RIM). In PSL rats, the threshold for responses induced by tactile stimulation with von Frey filaments was significantly decreased seven days after the operation, suggesting that the operation induced tactile allodynia. Orally administered tramadol showed a potent and dose-dependent antiallodynic effect on PSL-induced allodynia. In RIM rats, the threshold was significantly decreased five days after reserpine treatment. Orally administered tramadol also attenuated reserpine-induced tactile allodynia. To explore the mechanism of the antiallodynic effect of tramadol in RIM rats, we investigated the effect of the opioid antagonist naloxone on the tramadol-induced analgesic effect in these rats. The effect of tramadol was partially antagonized by naloxone, suggesting that the opioid receptor is involved at least in part in the antiallodynic effect of tramadol in RIM rats. These data indicate that orally administered tramadol produced improvement in both PSL rats and RIM rats at similar doses and provide evidence that the opioid system is partly involved in the analgesic effect of tramadol in RIM rats. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/24412679/The_analgesic_effect_of_tramadol_in_animal_models_of_neuropathic_pain_and_fibromyalgia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(14)00025-1 DB - PRIME DP - Unbound Medicine ER -