Pathologically confirmed malignant syphilis using immunohistochemical staining: report of 3 cases and review of the literature.Sex Transm Dis. 2014 Feb; 41(2):94-7.ST
Malignant syphilis is a rare ulcerative variety. In the classical description of the disease, the absence of spirochetes in tissue samples was considered as a diagnostic criterion. We report 3 cases of malignant syphilis; in all of them, spirochetes were identified in cutaneous biopsy samples using immunohistochemical staining.