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[Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats].
Zhong Yao Cai. 2013 Jul; 36(7):1123-7.ZY

Abstract

OBJECTIVE

To observe the effect of Panax notoginseng saponins (PNS) on cytokines production in liver fibrosis rats and its mechanism.

METHODS

SD rats were randomly divided into 6 groups, including normal group, liver fibrosis model group, PNS (50, 100, 200 mg/kg) treated groups and Col group. Rat liver fibrosis was induced by CCl4 twice a week for 18 weeks. PNS were administered daily from the 9th week for 10 weeks. The IL-1, IL-6, IL-10, TNF-alpha level in serum were determined by radioimmunity. The degree of liver fibrosis was observed by HE and immuninochemistry. The expression of TGF-beta, TNF-alpha mRNA were detected by RT-PCR technology.

RESULTS

Compared with the fibrotic model group, PNS (100, 200 mg/kg) could not only significantly reduce histopathological change, but also effectively decrease the level of IL-1, IL-6, NF-kappaB, TNF-alpha ,TGF-beta, and increase the level of IL-10.

CONCLUSION

PNS has protective effect on liver fibrosis and it maybe related to regulating cytokine network.

Links

clones/clone libraries

Authors+Show Affiliations

Jiang H
First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Grade 3 Laboratory of Traditional Chinese Medicine Preparation, State Administration of TCM, Hefei 230031, China. jhanbing@163.com
Wang YZ
First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Grade 3 Laboratory of Traditional Chinese Medicine Preparation, State Administration of TCM, Hefei 230031, China.
Liu XC
First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Grade 3 Laboratory of Traditional Chinese Medicine Preparation, State Administration of TCM, Hefei 230031, China.
Xue X
First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Grade 3 Laboratory of Traditional Chinese Medicine Preparation, State Administration of TCM, Hefei 230031, China.

MeSH

AnimalsCarbon TetrachlorideColchicineCytokinesDisease Models, AnimalGene Expression RegulationLiverLiver Cirrhosis, ExperimentalMaleNF-kappa BPanax notoginsengRNA, MessengerRandom AllocationRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionSaponinsTumor Necrosis Factor-alpha

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

24417151

Citation

Jiang, Hui, et al. "[Effect of Panax Notoginseng Saponins On Cytokines in Liver Fibrosis Rats]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 36, no. 7, 2013, pp. 1123-7.
Jiang H, Wang YZ, Liu XC, et al. [Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats]. Zhong Yao Cai. 2013;36(7):1123-7.
Jiang, H., Wang, Y. Z., Liu, X. C., & Xue, X. (2013). [Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 36(7), 1123-7.
Jiang H, et al. [Effect of Panax Notoginseng Saponins On Cytokines in Liver Fibrosis Rats]. Zhong Yao Cai. 2013;36(7):1123-7. PubMed PMID: 24417151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of Panax notoginseng saponins on cytokines in liver fibrosis rats]. AU - Jiang,Hui, AU - Wang,Yong-Zhong, AU - Liu,Xiao-Chuang, AU - Xue,Xue, PY - 2014/1/15/entrez PY - 2014/1/15/pubmed PY - 2014/7/6/medline SP - 1123 EP - 7 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 36 IS - 7 N2 - OBJECTIVE: To observe the effect of Panax notoginseng saponins (PNS) on cytokines production in liver fibrosis rats and its mechanism. METHODS: SD rats were randomly divided into 6 groups, including normal group, liver fibrosis model group, PNS (50, 100, 200 mg/kg) treated groups and Col group. Rat liver fibrosis was induced by CCl4 twice a week for 18 weeks. PNS were administered daily from the 9th week for 10 weeks. The IL-1, IL-6, IL-10, TNF-alpha level in serum were determined by radioimmunity. The degree of liver fibrosis was observed by HE and immuninochemistry. The expression of TGF-beta, TNF-alpha mRNA were detected by RT-PCR technology. RESULTS: Compared with the fibrotic model group, PNS (100, 200 mg/kg) could not only significantly reduce histopathological change, but also effectively decrease the level of IL-1, IL-6, NF-kappaB, TNF-alpha ,TGF-beta, and increase the level of IL-10. CONCLUSION: PNS has protective effect on liver fibrosis and it maybe related to regulating cytokine network. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/24417151/[Effect_of_Panax_notoginseng_saponins_on_cytokines_in_liver_fibrosis_rats]_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL6-1 DB - PRIME DP - Unbound Medicine ER -