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Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia.
BJOG. 2014 Apr; 121(5):575-81.BJOG

Abstract

OBJECTIVE

To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine the role of hyperandrogenaemia.

DESIGN

Cohort study.

SETTING

Singleton pregnancies in women with PCOS identified at a private fertility clinic during 1997-2010 and a background population including all singleton deliveries at Hvidovre Hospital, Denmark, in 2005.

POPULATION

A cohort of 459 women with PCOS and a background population of 5409 women.

METHODS

Obstetric outcomes were extracted from national Danish registries and odds ratios (ORs) were calculated by multiple logistic regression analysis, adjusting for age, parity, and body mass index.

MAIN OUTCOME MEASURES

Risk of pre-eclampsia, preterm delivery, and small for gestational age offspring in the entire PCOS population and in a subsample with hyperandrogenaemia.

RESULTS

Women with PCOS had an increased risk of preterm delivery <37 weeks of gestation (OR 2.28; 95% confidence interval, 95% CI, 1.51-3.45; P < 0.0001). The elevated risk was confined to hyperandrogenic women with PCOS: preterm delivery before 37 weeks of gestation (OR 2.78; 95% CI 1.62-4.77; P < 0.0001), and was not seen in normoandrogenic women with PCOS (OR 1.35; 95% CI 0.54-3.39; P = 0.52). The overall risk of pre-eclampsia was not elevated (OR 1.69; 95% CI 0.99-2.88; P = 0.05) compared with the background population, but was significantly increased in the hyperandrogenic subsample (OR 2.41; 95% CI 1.26-4.58; P < 0.001). The risk of small for gestational age offspring was similar in all groups.

CONCLUSION

Women with PCOS had an increased risk of preterm delivery compared with the background population. The increased risk was confined to hyperandrogenic women with PCOS who had a two-fold increased risk of preterm delivery and pre-eclampsia.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Hvidovre University Hospital, University of Copenhagen, Hvidovre, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24418062

Citation

Naver, K V., et al. "Increased Risk of Preterm Delivery and Pre-eclampsia in Women With Polycystic Ovary Syndrome and Hyperandrogenaemia." BJOG : an International Journal of Obstetrics and Gynaecology, vol. 121, no. 5, 2014, pp. 575-81.
Naver KV, Grinsted J, Larsen SO, et al. Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. BJOG. 2014;121(5):575-81.
Naver, K. V., Grinsted, J., Larsen, S. O., Hedley, P. L., Jørgensen, F. S., Christiansen, M., & Nilas, L. (2014). Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. BJOG : an International Journal of Obstetrics and Gynaecology, 121(5), 575-81. https://doi.org/10.1111/1471-0528.12558
Naver KV, et al. Increased Risk of Preterm Delivery and Pre-eclampsia in Women With Polycystic Ovary Syndrome and Hyperandrogenaemia. BJOG. 2014;121(5):575-81. PubMed PMID: 24418062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of preterm delivery and pre-eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia. AU - Naver,K V, AU - Grinsted,J, AU - Larsen,S O, AU - Hedley,P L, AU - Jørgensen,F S, AU - Christiansen,M, AU - Nilas,L, Y1 - 2014/01/13/ PY - 2013/10/18/accepted PY - 2014/1/15/entrez PY - 2014/1/15/pubmed PY - 2014/5/23/medline KW - Hyperandrogenaemia KW - polycystic ovary syndrome KW - pre-eclampsia KW - preterm delivery SP - 575 EP - 81 JF - BJOG : an international journal of obstetrics and gynaecology JO - BJOG VL - 121 IS - 5 N2 - OBJECTIVE: To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome (PCOS), and to examine the role of hyperandrogenaemia. DESIGN: Cohort study. SETTING: Singleton pregnancies in women with PCOS identified at a private fertility clinic during 1997-2010 and a background population including all singleton deliveries at Hvidovre Hospital, Denmark, in 2005. POPULATION: A cohort of 459 women with PCOS and a background population of 5409 women. METHODS: Obstetric outcomes were extracted from national Danish registries and odds ratios (ORs) were calculated by multiple logistic regression analysis, adjusting for age, parity, and body mass index. MAIN OUTCOME MEASURES: Risk of pre-eclampsia, preterm delivery, and small for gestational age offspring in the entire PCOS population and in a subsample with hyperandrogenaemia. RESULTS: Women with PCOS had an increased risk of preterm delivery <37 weeks of gestation (OR 2.28; 95% confidence interval, 95% CI, 1.51-3.45; P < 0.0001). The elevated risk was confined to hyperandrogenic women with PCOS: preterm delivery before 37 weeks of gestation (OR 2.78; 95% CI 1.62-4.77; P < 0.0001), and was not seen in normoandrogenic women with PCOS (OR 1.35; 95% CI 0.54-3.39; P = 0.52). The overall risk of pre-eclampsia was not elevated (OR 1.69; 95% CI 0.99-2.88; P = 0.05) compared with the background population, but was significantly increased in the hyperandrogenic subsample (OR 2.41; 95% CI 1.26-4.58; P < 0.001). The risk of small for gestational age offspring was similar in all groups. CONCLUSION: Women with PCOS had an increased risk of preterm delivery compared with the background population. The increased risk was confined to hyperandrogenic women with PCOS who had a two-fold increased risk of preterm delivery and pre-eclampsia. SN - 1471-0528 UR - https://www.unboundmedicine.com/medline/citation/24418062/Increased_risk_of_preterm_delivery_and_pre_eclampsia_in_women_with_polycystic_ovary_syndrome_and_hyperandrogenaemia_ L2 - https://doi.org/10.1111/1471-0528.12558 DB - PRIME DP - Unbound Medicine ER -