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Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial.
Nutr Res. 2014 Jan; 34(1):66-73.NR

Abstract

Human clinical trials targeted at preventing gains in body weight using soy protein and isoflavones are limited to adults and yield conflicting results. We hypothesized that daily intake of soy protein/isoflavones would attenuate gains in body weight to a greater extent than a casein-based control in 18 to 19 year-old females. To test this hypothesis, we conducted a randomized, double blind, placebo-controlled trial over 16 weeks to examine the effects of a soy protein/isoflavone-based meal replacement (experimental group) versus a casein-based meal replacement (control group) on body weight and body composition variables in female college freshmen (N = 120). Fat mass (FM), fat-free soft tissue mass (FFST), and percent body fat (%BF) were measured using dual energy X-ray absorptiometry (DXA; Delphi A). Repeated measures mixed models were used to determine the effects of treatment on anthropometric and body composition variables (body weight, waist circumference, FM, FFST, and %BF). No significant group×time interactions were observed, even when body mass index was controlled for in the analysis. Over 16 weeks, body weight, FM, FFST, and %BF significantly increased in both groups (P < .05). Our findings show that female college freshmen gained a significant amount of weight over the course of the 16-week study. Gains in body weight and FM were similar among participants assigned to the soy protein/isoflavone- and the casein-based meal replacements. Future research is warranted to determine the effects of soy protein/isoflavone- and casein-based meal replacements versus a non-intervention (i.e., non-protein based) control.

Authors+Show Affiliations

Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA.Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA.Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA.Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA.Department of Pediatrics, Georgia Regents University, Augusta, GA, USA.Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA.Physicians Pharmaceuticals, Inc., Winston-Salem, NC, USA.Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA.Department of Statistics, The University of Georgia, Athens, GA, USA.Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA. Electronic address: rlewis@fcs.uga.edu.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24418248

Citation

Berger, Paige K., et al. "Weight Gain in College Females Is Not Prevented By Isoflavone-rich Soy Protein: a Randomized Controlled Trial." Nutrition Research (New York, N.Y.), vol. 34, no. 1, 2014, pp. 66-73.
Berger PK, Principe JL, Laing EM, et al. Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial. Nutr Res. 2014;34(1):66-73.
Berger, P. K., Principe, J. L., Laing, E. M., Henley, E. C., Pollock, N. K., Taylor, R. G., Blair, R. M., Baile, C. A., Hall, D. B., & Lewis, R. D. (2014). Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial. Nutrition Research (New York, N.Y.), 34(1), 66-73. https://doi.org/10.1016/j.nutres.2013.09.005
Berger PK, et al. Weight Gain in College Females Is Not Prevented By Isoflavone-rich Soy Protein: a Randomized Controlled Trial. Nutr Res. 2014;34(1):66-73. PubMed PMID: 24418248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Weight gain in college females is not prevented by isoflavone-rich soy protein: a randomized controlled trial. AU - Berger,Paige K, AU - Principe,Jessica L, AU - Laing,Emma M, AU - Henley,E C, AU - Pollock,Norman K, AU - Taylor,Ruth G, AU - Blair,Robert M, AU - Baile,Clifton A, AU - Hall,Daniel B, AU - Lewis,Richard D, Y1 - 2013/10/22/ PY - 2013/05/20/received PY - 2013/09/17/revised PY - 2013/09/18/accepted PY - 2014/1/15/entrez PY - 2014/1/15/pubmed PY - 2014/9/3/medline KW - %BF KW - Body weight KW - CAS KW - Caseins KW - Collegiate females KW - DXA KW - FFST KW - FM KW - ICCs KW - Isoflavones KW - LC-MS/MS KW - SOY KW - Seattle Soy Food Frequency Questionnaire. KW - Soy FFQ KW - Soybean proteins KW - body fat percentage KW - casein-based group KW - dual energy X-ray absorptiometry KW - fat mass KW - fat-free soft tissue KW - intraclass correlation coefficients KW - liquid chromatography-tandem mass spectrometry KW - soy protein/isoflavone-group SP - 66 EP - 73 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 1 N2 - Human clinical trials targeted at preventing gains in body weight using soy protein and isoflavones are limited to adults and yield conflicting results. We hypothesized that daily intake of soy protein/isoflavones would attenuate gains in body weight to a greater extent than a casein-based control in 18 to 19 year-old females. To test this hypothesis, we conducted a randomized, double blind, placebo-controlled trial over 16 weeks to examine the effects of a soy protein/isoflavone-based meal replacement (experimental group) versus a casein-based meal replacement (control group) on body weight and body composition variables in female college freshmen (N = 120). Fat mass (FM), fat-free soft tissue mass (FFST), and percent body fat (%BF) were measured using dual energy X-ray absorptiometry (DXA; Delphi A). Repeated measures mixed models were used to determine the effects of treatment on anthropometric and body composition variables (body weight, waist circumference, FM, FFST, and %BF). No significant group×time interactions were observed, even when body mass index was controlled for in the analysis. Over 16 weeks, body weight, FM, FFST, and %BF significantly increased in both groups (P < .05). Our findings show that female college freshmen gained a significant amount of weight over the course of the 16-week study. Gains in body weight and FM were similar among participants assigned to the soy protein/isoflavone- and the casein-based meal replacements. Future research is warranted to determine the effects of soy protein/isoflavone- and casein-based meal replacements versus a non-intervention (i.e., non-protein based) control. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24418248/Weight_gain_in_college_females_is_not_prevented_by_isoflavone_rich_soy_protein:_a_randomized_controlled_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00225-X DB - PRIME DP - Unbound Medicine ER -