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Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum.
Fitoterapia. 2014 Mar; 93:126-31.F

Abstract

Chaetoglobosin Y (1), was isolated from the endolichenic fungal strain Chaetomium globosum (No. 64-5-8-2), along with related six known cytochalasans, chaetoglobosin Fex (2), chaetoglobosin E (3), isochaetoglobosin D (4), chaetoglobosin G (5), cytoglobosin B (6), and cytoglobosin C (7). Their structures were determined by detailed spectroscopic analyses and comparison with those of the closely related compounds previously reported. The cytotoxicity to HCT-116 cell line of 2-7 was evaluated in vitro with doxorubicin as positive control.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zheng QC
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Kong MZ
Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, PR China.
Zhao Q
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Chen GD
Department of Pharmaceutical Engineering, South China Agricultural University, Guangzhou 510642, PR China. Electronic address: chgdtong@163.com.
Tian HY
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Li XX
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Guo LD
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
Li J
National Center for Drug Screening, and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai 201203, PR China.
Zheng YZ
Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, PR China.
Gao H
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tghao@jnu.edu.cn.

MeSH

Antineoplastic AgentsChaetomiumDrug Screening Assays, AntitumorHCT116 CellsHumansIndole AlkaloidsMolecular Structure

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24418656

Citation

Zheng, Qi-Chang, et al. "Chaetoglobosin Y, a New Cytochalasan From Chaetomium Globosum." Fitoterapia, vol. 93, 2014, pp. 126-31.
Zheng QC, Kong MZ, Zhao Q, et al. Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum. Fitoterapia. 2014;93:126-31.
Zheng, Q. C., Kong, M. Z., Zhao, Q., Chen, G. D., Tian, H. Y., Li, X. X., Guo, L. D., Li, J., Zheng, Y. Z., & Gao, H. (2014). Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum. Fitoterapia, 93, 126-31. https://doi.org/10.1016/j.fitote.2013.12.022
Zheng QC, et al. Chaetoglobosin Y, a New Cytochalasan From Chaetomium Globosum. Fitoterapia. 2014;93:126-31. PubMed PMID: 24418656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum. AU - Zheng,Qi-Chang, AU - Kong,Ming-Zhu, AU - Zhao,Qin, AU - Chen,Guo-Dong, AU - Tian,Hai-Yan, AU - Li,Xiao-Xia, AU - Guo,Liang-Dong, AU - Li,Jia, AU - Zheng,Yi-Zhi, AU - Gao,Hao, Y1 - 2014/01/11/ PY - 2013/09/23/received PY - 2013/12/21/revised PY - 2013/12/23/accepted PY - 2014/1/15/entrez PY - 2014/1/15/pubmed PY - 2015/2/24/medline KW - Chaetoglobosins KW - Chaetomiaceae KW - Chaetomium globosum KW - Cytochalasans KW - Cytotoxicity SP - 126 EP - 31 JF - Fitoterapia JO - Fitoterapia VL - 93 N2 - Chaetoglobosin Y (1), was isolated from the endolichenic fungal strain Chaetomium globosum (No. 64-5-8-2), along with related six known cytochalasans, chaetoglobosin Fex (2), chaetoglobosin E (3), isochaetoglobosin D (4), chaetoglobosin G (5), cytoglobosin B (6), and cytoglobosin C (7). Their structures were determined by detailed spectroscopic analyses and comparison with those of the closely related compounds previously reported. The cytotoxicity to HCT-116 cell line of 2-7 was evaluated in vitro with doxorubicin as positive control. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/24418656/Chaetoglobosin_Y_a_new_cytochalasan_from_Chaetomium_globosum_ DB - PRIME DP - Unbound Medicine ER -