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Associations of serum sclerostin and polymorphisms in the SOST gene with bone mineral density and markers of bone metabolism in postmenopausal Chinese women.
J Clin Endocrinol Metab. 2014 Apr; 99(4):E665-73.JC

Abstract

OBJECTIVE

The aims of this study were as follows: 1) to evaluate the association of serum sclerostin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal Chinese women and 2) to observe the relationships of single-nucleotide polymorphisms (SNPs) within the sclerostin (SOST) gene with serum sclerostin, BMD, and markers of bone metabolism.

DESIGN

A cross-sectional study was conducted with 703 postmenopausal Chinese women. Ten tagging SNPs (rs1234612, rs1513670, rs1634330, rs1708635, rs2023794, rs7220711, rs74252774, rs851057, rs851058, and rs865429) of the SOST gene were genotyped. Serum sclerostin and markers of bone metabolism were measured, including serum intact PTH, 25-hydroxyvitamin D [25(OH)D], procollagen type 1 N-terminal propeptide, and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX). The BMD of the lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry.

RESULTS

Serum sclerostin was positively correlated with BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D (all P < .01) but negatively correlated with β-CTX (P < .01). The significant relationships between serum sclerostin and BMD and with serum β-CTX persisted, even after adjustments for age, body mass index, and serum 25(OH)D (all P < .01). However, there was no correlation between serum sclerostin and age or serum procollagen type 1 N-terminal propeptide. We failed to identify a significant association between the SNP, haplotypes of SOST and BMD, or serum sclerostin.

CONCLUSION

Our results suggested that serum sclerostin was positively correlated with the BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D but was negatively correlated with serum β-CTX. Genetic polymorphisms of SOST may not be a major contributor to variations in the serum sclerostin or BMD in postmenopausal Chinese women.

Authors+Show Affiliations

Metabolic Bone Diseases and Genetic Research Unit (J.H., H.Zha., C.W., H.Y., W.H., J.G., W.F., Y.H., M.L., Y.L., H.Zhe., Zh.Z.), Department of Osteoporosis and Bone Diseases, and Department of Orthopedics (Ze.Z.), Shanghai Jiao Tong University Affiliated with Sixth People's Hospital 200233 Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24423318

Citation

He, Jinwei, et al. "Associations of Serum Sclerostin and Polymorphisms in the SOST Gene With Bone Mineral Density and Markers of Bone Metabolism in Postmenopausal Chinese Women." The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 4, 2014, pp. E665-73.
He J, Zhang H, Wang C, et al. Associations of serum sclerostin and polymorphisms in the SOST gene with bone mineral density and markers of bone metabolism in postmenopausal Chinese women. J Clin Endocrinol Metab. 2014;99(4):E665-73.
He, J., Zhang, H., Wang, C., Zhang, Z., Yue, H., Hu, W., Gu, J., Fu, W., Hu, Y., Li, M., Liu, Y., Zheng, H., & Zhang, Z. (2014). Associations of serum sclerostin and polymorphisms in the SOST gene with bone mineral density and markers of bone metabolism in postmenopausal Chinese women. The Journal of Clinical Endocrinology and Metabolism, 99(4), E665-73. https://doi.org/10.1210/jc.2013-2086
He J, et al. Associations of Serum Sclerostin and Polymorphisms in the SOST Gene With Bone Mineral Density and Markers of Bone Metabolism in Postmenopausal Chinese Women. J Clin Endocrinol Metab. 2014;99(4):E665-73. PubMed PMID: 24423318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of serum sclerostin and polymorphisms in the SOST gene with bone mineral density and markers of bone metabolism in postmenopausal Chinese women. AU - He,Jinwei, AU - Zhang,Hao, AU - Wang,Chun, AU - Zhang,Zeng, AU - Yue,Hua, AU - Hu,Weiwei, AU - Gu,Jiemei, AU - Fu,Wenzhen, AU - Hu,Yunqiu, AU - Li,Miao, AU - Liu,Yujuan, AU - Zheng,Hui, AU - Zhang,Zhenlin, Y1 - 2014/01/01/ PY - 2014/1/16/entrez PY - 2014/1/16/pubmed PY - 2014/6/4/medline SP - E665 EP - 73 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 99 IS - 4 N2 - OBJECTIVE: The aims of this study were as follows: 1) to evaluate the association of serum sclerostin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal Chinese women and 2) to observe the relationships of single-nucleotide polymorphisms (SNPs) within the sclerostin (SOST) gene with serum sclerostin, BMD, and markers of bone metabolism. DESIGN: A cross-sectional study was conducted with 703 postmenopausal Chinese women. Ten tagging SNPs (rs1234612, rs1513670, rs1634330, rs1708635, rs2023794, rs7220711, rs74252774, rs851057, rs851058, and rs865429) of the SOST gene were genotyped. Serum sclerostin and markers of bone metabolism were measured, including serum intact PTH, 25-hydroxyvitamin D [25(OH)D], procollagen type 1 N-terminal propeptide, and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX). The BMD of the lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry. RESULTS: Serum sclerostin was positively correlated with BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D (all P < .01) but negatively correlated with β-CTX (P < .01). The significant relationships between serum sclerostin and BMD and with serum β-CTX persisted, even after adjustments for age, body mass index, and serum 25(OH)D (all P < .01). However, there was no correlation between serum sclerostin and age or serum procollagen type 1 N-terminal propeptide. We failed to identify a significant association between the SNP, haplotypes of SOST and BMD, or serum sclerostin. CONCLUSION: Our results suggested that serum sclerostin was positively correlated with the BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D but was negatively correlated with serum β-CTX. Genetic polymorphisms of SOST may not be a major contributor to variations in the serum sclerostin or BMD in postmenopausal Chinese women. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/24423318/Associations_of_serum_sclerostin_and_polymorphisms_in_the_SOST_gene_with_bone_mineral_density_and_markers_of_bone_metabolism_in_postmenopausal_Chinese_women_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2013-2086 DB - PRIME DP - Unbound Medicine ER -