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A meta-analysis of inositol for depression and anxiety disorders.

Abstract

OBJECTIVE

This study is a meta-analysis of inositol as a treatment for depression and anxiety disorders.

METHODS

PubMed, Cochrane Library database, and PsycINFO were searched up to 14 August 2013. A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials (RCTs) were conducted comparing inositol for depressed or anxiety disorder patients.

RESULTS

Seven RCTs in depression (two bipolar depression studies, one bipolar depression and major depressive disorder (MDD) study, two MDD studies, and two premenstrual dysphoric disorder (PMDD) studies) (n = 242) were identified. Four RCTs in anxiety disorders (two obsessive-compulsive disorder studies, one panic disorder study, and one posttraumatic stress disorder study) (n = 70) were also identified. There were no statistically significant effects of inositol on depressive, anxiety, and obsessive-compulsive symptoms and discontinuation (all-cause, side effects, and worsening psychiatric symptoms). However, inositol had marginally more responders in depression than placebo (p = 0.06), and inositol showed a trend towards superior efficacy for depressive symptoms in patients with PMDD (p = 0.07). Inositol marginally caused gastrointestinal upset compared with placebo (p = 0.06).

CONCLUSIONS

Our results suggest that inositol may be beneficial for depressed patients, especially those with PMDD. The main limitation of this report is that a small number of studies were included in this meta-analysis.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan.

    , ,

    Source

    Human psychopharmacology 29:1 2014 Jan pg 55-63

    MeSH

    Anxiety Disorders
    Depressive Disorder
    Humans
    Inositol
    Randomized Controlled Trials as Topic
    Treatment Outcome
    Vitamin B Complex

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    24424706

    Citation

    Mukai, Tomohiko, et al. "A Meta-analysis of Inositol for Depression and Anxiety Disorders." Human Psychopharmacology, vol. 29, no. 1, 2014, pp. 55-63.
    Mukai T, Kishi T, Matsuda Y, et al. A meta-analysis of inositol for depression and anxiety disorders. Hum Psychopharmacol. 2014;29(1):55-63.
    Mukai, T., Kishi, T., Matsuda, Y., & Iwata, N. (2014). A meta-analysis of inositol for depression and anxiety disorders. Human Psychopharmacology, 29(1), pp. 55-63. doi:10.1002/hup.2369.
    Mukai T, et al. A Meta-analysis of Inositol for Depression and Anxiety Disorders. Hum Psychopharmacol. 2014;29(1):55-63. PubMed PMID: 24424706.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A meta-analysis of inositol for depression and anxiety disorders. AU - Mukai,Tomohiko, AU - Kishi,Taro, AU - Matsuda,Yuki, AU - Iwata,Nakao, Y1 - 2013/12/03/ PY - 2013/06/01/received PY - 2013/09/13/revised PY - 2013/10/16/accepted PY - 2014/1/16/entrez PY - 2014/1/16/pubmed PY - 2014/9/16/medline KW - anxiety disorder KW - bipolar depression KW - inositol KW - major depressive disorder KW - meta-analysis KW - premenstrual dysphoric disorder SP - 55 EP - 63 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 29 IS - 1 N2 - OBJECTIVE: This study is a meta-analysis of inositol as a treatment for depression and anxiety disorders. METHODS: PubMed, Cochrane Library database, and PsycINFO were searched up to 14 August 2013. A systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials (RCTs) were conducted comparing inositol for depressed or anxiety disorder patients. RESULTS: Seven RCTs in depression (two bipolar depression studies, one bipolar depression and major depressive disorder (MDD) study, two MDD studies, and two premenstrual dysphoric disorder (PMDD) studies) (n = 242) were identified. Four RCTs in anxiety disorders (two obsessive-compulsive disorder studies, one panic disorder study, and one posttraumatic stress disorder study) (n = 70) were also identified. There were no statistically significant effects of inositol on depressive, anxiety, and obsessive-compulsive symptoms and discontinuation (all-cause, side effects, and worsening psychiatric symptoms). However, inositol had marginally more responders in depression than placebo (p = 0.06), and inositol showed a trend towards superior efficacy for depressive symptoms in patients with PMDD (p = 0.07). Inositol marginally caused gastrointestinal upset compared with placebo (p = 0.06). CONCLUSIONS: Our results suggest that inositol may be beneficial for depressed patients, especially those with PMDD. The main limitation of this report is that a small number of studies were included in this meta-analysis. SN - 1099-1077 UR - https://www.unboundmedicine.com/medline/citation/24424706/full_citation L2 - https://doi.org/10.1002/hup.2369 DB - PRIME DP - Unbound Medicine ER -