TY - JOUR T1 - Antifungal Metabolites Produced by Chaetomium globosum No.04, an Endophytic Fungus Isolated from Ginkgo biloba. AU - Zhang,Guizhen, AU - Zhang,Yanhua, AU - Qin,Jianchun, AU - Qu,Xiaoyan, AU - Liu,Jinliang, AU - Li,Xiang, AU - Pan,Hongyu, Y1 - 2013/02/09/ PY - 2012/05/23/received PY - 2013/01/22/accepted PY - 2014/1/16/entrez PY - 2014/1/16/pubmed PY - 2014/1/16/medline KW - Antifungal activity KW - Chaetoglobosins KW - Chaetomium globosum SP - 175 EP - 80 JF - Indian journal of microbiology JO - Indian J Microbiol VL - 53 IS - 2 N2 - The fungal endophyte Chaetomium globosum No.04 was isolated from the medicinal plant Ginkgo biloba. The crude extract of the fungus fermentation were active in the agar-diffusion tests against the phytopathogenic fungi Rhizopus stolonifer and Coniothyrium diplodiella. Further bioassay-guided chemical investigation led to the isolation and purification of six alkaloids and three non-targeted compounds from 50 L fermentation of this endophytic fungus and their structures were elucidated as chaetoglobosin A, C, D, E, G, R (1-6), ergosterol, allantoin and uracil, by means of spectroscopic analysis. Compounds 1-6 showed significant growth inhibitory activity against R. stolonifer and C. diplodiella at a concentration of 20 μg/disc. We present here, for the first time, the potent antifungal activity of chaetoglobosins from endophytic fungi against two important phytopathogenic fungi R. stolonifer and C. diplodiella. SN - 0046-8991 UR - https://www.unboundmedicine.com/medline/citation/24426105/Antifungal_Metabolites_Produced_by_Chaetomium_globosum_No_04_an_Endophytic_Fungus_Isolated_from_Ginkgo_biloba_ DB - PRIME DP - Unbound Medicine ER -