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Adriamycin-induced histamine release from rat peritoneal mast cells: role of free radicals.
Anticancer Res. 1987 May-Jun; 7(3 Pt B):497-9.AR

Abstract

The effect of pretreatment with various concentrations of catalase, superoxide-dismutase, D-mannitol, alpha-tocopherol, n-acetylcysteine and reduced glutathione on the release of histamine induced by adriamycin (100 micrograms/ml) on rat peritoneal mast cells was studied. Adriamycin caused an important histamine release in vitro which was not affected by pretreatment with the tested substances. Only n-acetylcysteine, at a very high concentration (1 X 10(-1) M) significantly limited this release. The substance was also active in inhibiting the release induced by a classic mast cell secretagogue, compound 48/80.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2443072

Citation

Decorti, G, et al. "Adriamycin-induced Histamine Release From Rat Peritoneal Mast Cells: Role of Free Radicals." Anticancer Research, vol. 7, no. 3 Pt B, 1987, pp. 497-9.
Decorti G, Klugmann FB, Candussio L, et al. Adriamycin-induced histamine release from rat peritoneal mast cells: role of free radicals. Anticancer Res. 1987;7(3 Pt B):497-9.
Decorti, G., Klugmann, F. B., Candussio, L., & Baldini, L. (1987). Adriamycin-induced histamine release from rat peritoneal mast cells: role of free radicals. Anticancer Research, 7(3 Pt B), 497-9.
Decorti G, et al. Adriamycin-induced Histamine Release From Rat Peritoneal Mast Cells: Role of Free Radicals. Anticancer Res. 1987 May-Jun;7(3 Pt B):497-9. PubMed PMID: 2443072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adriamycin-induced histamine release from rat peritoneal mast cells: role of free radicals. AU - Decorti,G, AU - Klugmann,F B, AU - Candussio,L, AU - Baldini,L, PY - 1987/5/1/pubmed PY - 1987/5/1/medline PY - 1987/5/1/entrez SP - 497 EP - 9 JF - Anticancer research JO - Anticancer Res VL - 7 IS - 3 Pt B N2 - The effect of pretreatment with various concentrations of catalase, superoxide-dismutase, D-mannitol, alpha-tocopherol, n-acetylcysteine and reduced glutathione on the release of histamine induced by adriamycin (100 micrograms/ml) on rat peritoneal mast cells was studied. Adriamycin caused an important histamine release in vitro which was not affected by pretreatment with the tested substances. Only n-acetylcysteine, at a very high concentration (1 X 10(-1) M) significantly limited this release. The substance was also active in inhibiting the release induced by a classic mast cell secretagogue, compound 48/80. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/2443072/Adriamycin_induced_histamine_release_from_rat_peritoneal_mast_cells:_role_of_free_radicals_ DB - PRIME DP - Unbound Medicine ER -