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Metabolic syndrome and prostate abnormalities in male subjects of infertile couples.
Asian J Androl. 2014 Mar-Apr; 16(2):295-304.AJ

Abstract

No previous study has evaluated systematically the relationship between metabolic syndrome (MetS) and prostate-related symptoms and signs in young infertile men. We studied 171 (36.5 ± 8.3-years-old) males of infertile couples. MetS was defined based on the National Cholesterol Education Program Third Adult Treatment Panel. All men underwent hormonal (including total testosterone (TT) and insulin), seminal (including interleukin-8 (IL-8), seminal plasma IL-8 (sIL-8)), scrotal and transrectal ultrasound evaluations. Because we have previously assessed correlations between MetS and scrotal parameters in a larger cohort of infertile men, here, we focused on transrectal features. Prostate-related symptoms were assessed using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostate Symptom Score (IPSS). Twenty-two subjects fulfilled MetS criteria. In an age-adjusted logistic ordinal model, insulin levels increased as a function of MetS components (Wald = 29.5, P < 0.0001) and showed an inverse correlation with TT (adjusted r = -0.359, P< 0.0001). No association between MetS and NIH-CPSI or IPSS scores was observed. In an age-, TT-, insulin-adjusted logistic ordinal model, an increase in number of MetS components correlated negatively with normal sperm morphology (Wald = 5.59, P< 0.02) and positively with sIL-8 levels (Wald = 4.32, P < 0.05), which is a marker of prostate inflammation, with prostate total and transitional zone volume assessed using ultrasound (Wald = 17.6 and 12.5, both P < 0.0001), with arterial peak systolic velocity (Wald = 9.57, P = 0.002), with texture nonhomogeneity (hazard ratio (HR) = 1.87 (1.05-3.33), P < 0.05), with calcification size (Wald = 3.11, P< 0.05), but not with parameters of seminal vesicle size or function. In conclusion, in males of infertile couples, MetS is positively associated with prostate enlargement, biochemical (sIL8) and ultrasound-derived signs of prostate inflammation but not with prostate-related symptoms, which suggests that MetS is a trigger for a subclinical, early-onset form of benign prostatic hyperplasia.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableSexual Medicine and Andrology Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24435050

Citation

Lotti, Francesco, et al. "Metabolic Syndrome and Prostate Abnormalities in Male Subjects of Infertile Couples." Asian Journal of Andrology, vol. 16, no. 2, 2014, pp. 295-304.
Lotti F, Corona G, Vignozzi L, et al. Metabolic syndrome and prostate abnormalities in male subjects of infertile couples. Asian J Androl. 2014;16(2):295-304.
Lotti, F., Corona, G., Vignozzi, L., Rossi, M., Maseroli, E., Cipriani, S., Gacci, M., Forti, G., & Maggi, M. (2014). Metabolic syndrome and prostate abnormalities in male subjects of infertile couples. Asian Journal of Andrology, 16(2), 295-304. https://doi.org/10.4103/1008-682X.122341
Lotti F, et al. Metabolic Syndrome and Prostate Abnormalities in Male Subjects of Infertile Couples. Asian J Androl. 2014 Mar-Apr;16(2):295-304. PubMed PMID: 24435050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and prostate abnormalities in male subjects of infertile couples. AU - Lotti,Francesco, AU - Corona,Giovanni, AU - Vignozzi,Linda, AU - Rossi,Matteo, AU - Maseroli,Elisa, AU - Cipriani,Sarah, AU - Gacci,Mauro, AU - Forti,Gianni, AU - Maggi,Mario, PY - 2014/1/18/entrez PY - 2014/1/18/pubmed PY - 2014/11/15/medline SP - 295 EP - 304 JF - Asian journal of andrology JO - Asian J. Androl. VL - 16 IS - 2 N2 - No previous study has evaluated systematically the relationship between metabolic syndrome (MetS) and prostate-related symptoms and signs in young infertile men. We studied 171 (36.5 ± 8.3-years-old) males of infertile couples. MetS was defined based on the National Cholesterol Education Program Third Adult Treatment Panel. All men underwent hormonal (including total testosterone (TT) and insulin), seminal (including interleukin-8 (IL-8), seminal plasma IL-8 (sIL-8)), scrotal and transrectal ultrasound evaluations. Because we have previously assessed correlations between MetS and scrotal parameters in a larger cohort of infertile men, here, we focused on transrectal features. Prostate-related symptoms were assessed using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostate Symptom Score (IPSS). Twenty-two subjects fulfilled MetS criteria. In an age-adjusted logistic ordinal model, insulin levels increased as a function of MetS components (Wald = 29.5, P < 0.0001) and showed an inverse correlation with TT (adjusted r = -0.359, P< 0.0001). No association between MetS and NIH-CPSI or IPSS scores was observed. In an age-, TT-, insulin-adjusted logistic ordinal model, an increase in number of MetS components correlated negatively with normal sperm morphology (Wald = 5.59, P< 0.02) and positively with sIL-8 levels (Wald = 4.32, P < 0.05), which is a marker of prostate inflammation, with prostate total and transitional zone volume assessed using ultrasound (Wald = 17.6 and 12.5, both P < 0.0001), with arterial peak systolic velocity (Wald = 9.57, P = 0.002), with texture nonhomogeneity (hazard ratio (HR) = 1.87 (1.05-3.33), P < 0.05), with calcification size (Wald = 3.11, P< 0.05), but not with parameters of seminal vesicle size or function. In conclusion, in males of infertile couples, MetS is positively associated with prostate enlargement, biochemical (sIL8) and ultrasound-derived signs of prostate inflammation but not with prostate-related symptoms, which suggests that MetS is a trigger for a subclinical, early-onset form of benign prostatic hyperplasia. SN - 1745-7262 UR - https://www.unboundmedicine.com/medline/citation/24435050/Metabolic_syndrome_and_prostate_abnormalities_in_male_subjects_of_infertile_couples_ L2 - http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=2;spage=295;epage=304;aulast=Lotti DB - PRIME DP - Unbound Medicine ER -