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The incidence of premalignant and malignant disease in Reinke's edema.
Otolaryngol Head Neck Surg. 2014 Mar; 150(3):434-6.OH

Abstract

Reinke's edema is a benign lesion of the vocal folds affecting the subepithelial space. As part of a study of the management of Reinke's edema, we aimed to determine the prevalence of dysplasia and malignancy in histologically proven Reinke's edema. A retrospective analysis of all laryngeal biopsies performed in north Glasgow, United Kingdom, between 2001 and 2010 was carried out. Clinical and pathological data from patients with histologically confirmed Reinke's edema were recorded with specific respect to the reporting of dysplasia and malignancy. From the 10-year cohort, a total of 3902 laryngeal biopsies were performed. In total, 189 patients (18 males and 171 females) had histologically proven Reinke's edema. Of this cohort, 170 (90%) had no dysplasia, 16 (8%) had mild dysplasia, 2 (1%) had moderate dysplasia, and 1 (<1%) had severe dysplasia. There was no malignancy reported. In our predominantly female smoking population, the epithelium appears to differentiate to benign Reinke's edema rather than malignancy. Patients can be reassured with regard to the low risk of malignancy in classic Reinke's edema.

Authors+Show Affiliations

Department of Otolaryngology Head and Neck Surgery, Glasgow Royal Infirmary, Glasgow, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24436463

Citation

Lim, Shueh, et al. "The Incidence of Premalignant and Malignant Disease in Reinke's Edema." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 150, no. 3, 2014, pp. 434-6.
Lim S, Sau P, Cooper L, et al. The incidence of premalignant and malignant disease in Reinke's edema. Otolaryngol Head Neck Surg. 2014;150(3):434-6.
Lim, S., Sau, P., Cooper, L., McPhaden, A., & Mackenzie, K. (2014). The incidence of premalignant and malignant disease in Reinke's edema. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(3), 434-6. https://doi.org/10.1177/0194599813520123
Lim S, et al. The Incidence of Premalignant and Malignant Disease in Reinke's Edema. Otolaryngol Head Neck Surg. 2014;150(3):434-6. PubMed PMID: 24436463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The incidence of premalignant and malignant disease in Reinke's edema. AU - Lim,Shueh, AU - Sau,Phoebe, AU - Cooper,Lorna, AU - McPhaden,Allan, AU - Mackenzie,Kenneth, Y1 - 2014/01/16/ PY - 2014/1/18/entrez PY - 2014/1/18/pubmed PY - 2014/4/23/medline KW - Reinke’s edema KW - benign KW - dysplasia KW - larynx KW - malignancy SP - 434 EP - 6 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 150 IS - 3 N2 - Reinke's edema is a benign lesion of the vocal folds affecting the subepithelial space. As part of a study of the management of Reinke's edema, we aimed to determine the prevalence of dysplasia and malignancy in histologically proven Reinke's edema. A retrospective analysis of all laryngeal biopsies performed in north Glasgow, United Kingdom, between 2001 and 2010 was carried out. Clinical and pathological data from patients with histologically confirmed Reinke's edema were recorded with specific respect to the reporting of dysplasia and malignancy. From the 10-year cohort, a total of 3902 laryngeal biopsies were performed. In total, 189 patients (18 males and 171 females) had histologically proven Reinke's edema. Of this cohort, 170 (90%) had no dysplasia, 16 (8%) had mild dysplasia, 2 (1%) had moderate dysplasia, and 1 (<1%) had severe dysplasia. There was no malignancy reported. In our predominantly female smoking population, the epithelium appears to differentiate to benign Reinke's edema rather than malignancy. Patients can be reassured with regard to the low risk of malignancy in classic Reinke's edema. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/24436463/The_incidence_of_premalignant_and_malignant_disease_in_Reinke's_edema_ L2 - http://journals.sagepub.com/doi/full/10.1177/0194599813520123?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -