Tags

Type your tag names separated by a space and hit enter

Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis.

Abstract

BACKGROUND

There is no consensus on the type, time of initiation, or duration of use of enteral nutrition in patients with chronic kidney disease (CKD). This study aimed to compare the effects of a renal-specific oral nutrition supplement (RS-ONS) and a standard recommended nutrition regime on biochemical and nutrition markers in malnourished patients with CKD on hemodialysis.

METHODS

Sixty-two malnourished patients with CKD, divided into experimental (RS-ONS; n = 32; mean [SD] age, 62.0 [11.3] years; 55.2% female) and control (CON; n = 30; mean [SD] age, 57.2 [12.3] years; 31% female) groups, were evaluated for anthropometric, biochemical, and inflammatory parameters.

RESULTS

Mean (SD) serum albumin levels were significantly increased in the RS-ONS group from 3.5 (0.3) g/dL at baseline to 3.7 (0.2) g/dL at 6 months (P = .028). Significantly fewer patients had serum albumin levels of <3.5 g/dL after month 6. Dry weight of patients significantly increased in the RS-ONS but decreased in the CON groups (P < .001 for each). Percent change from baseline revealed negative results for bioelectrical impedance analysis (P < .001) in the CON group. Malnutrition inflammation score at 6 months (P = .006) and erythropoietin (EPO) dose requirements were higher in the CON group (P = .012).

CONCLUSIONS

Our findings indicate that consuming RS-ONS improves serum albumin and anthropometric measures, as well as reduces EPO dose, in patients with CKD.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey sirensezer@hotmail.com.

    ,

    Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey.

    ,

    Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey.

    ,

    Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey.

    Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey.

    Source

    MeSH

    Administration, Oral
    Aged
    Body Weight
    Dietary Supplements
    Electric Impedance
    Erythropoietin
    Female
    Humans
    Male
    Malnutrition
    Middle Aged
    Nutritional Status
    Renal Dialysis
    Renal Insufficiency, Chronic
    Serum Albumin

    Pub Type(s)

    Controlled Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24436491

    Citation

    Sezer, Siren, et al. "Long-term Oral Nutrition Supplementation Improves Outcomes in Malnourished Patients With Chronic Kidney Disease On Hemodialysis." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 38, no. 8, 2014, pp. 960-5.
    Sezer S, Bal Z, Tutal E, et al. Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis. JPEN J Parenter Enteral Nutr. 2014;38(8):960-5.
    Sezer, S., Bal, Z., Tutal, E., Uyar, M. E., & Acar, N. O. (2014). Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis. JPEN. Journal of Parenteral and Enteral Nutrition, 38(8), pp. 960-5. doi:10.1177/0148607113517266.
    Sezer S, et al. Long-term Oral Nutrition Supplementation Improves Outcomes in Malnourished Patients With Chronic Kidney Disease On Hemodialysis. JPEN J Parenter Enteral Nutr. 2014;38(8):960-5. PubMed PMID: 24436491.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis. AU - Sezer,Siren, AU - Bal,Zeynep, AU - Tutal,Emre, AU - Uyar,Mehtap Erkmen, AU - Acar,Nurhan Ozdemir, Y1 - 2014/01/16/ PY - 2014/1/18/entrez PY - 2014/1/18/pubmed PY - 2015/6/5/medline KW - anthropometrics KW - chronic renal disease KW - dialysis KW - malnutrition KW - oral nutritional supplements SP - 960 EP - 5 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 38 IS - 8 N2 - BACKGROUND: There is no consensus on the type, time of initiation, or duration of use of enteral nutrition in patients with chronic kidney disease (CKD). This study aimed to compare the effects of a renal-specific oral nutrition supplement (RS-ONS) and a standard recommended nutrition regime on biochemical and nutrition markers in malnourished patients with CKD on hemodialysis. METHODS: Sixty-two malnourished patients with CKD, divided into experimental (RS-ONS; n = 32; mean [SD] age, 62.0 [11.3] years; 55.2% female) and control (CON; n = 30; mean [SD] age, 57.2 [12.3] years; 31% female) groups, were evaluated for anthropometric, biochemical, and inflammatory parameters. RESULTS: Mean (SD) serum albumin levels were significantly increased in the RS-ONS group from 3.5 (0.3) g/dL at baseline to 3.7 (0.2) g/dL at 6 months (P = .028). Significantly fewer patients had serum albumin levels of <3.5 g/dL after month 6. Dry weight of patients significantly increased in the RS-ONS but decreased in the CON groups (P < .001 for each). Percent change from baseline revealed negative results for bioelectrical impedance analysis (P < .001) in the CON group. Malnutrition inflammation score at 6 months (P = .006) and erythropoietin (EPO) dose requirements were higher in the CON group (P = .012). CONCLUSIONS: Our findings indicate that consuming RS-ONS improves serum albumin and anthropometric measures, as well as reduces EPO dose, in patients with CKD. SN - 1941-2444 UR - https://www.unboundmedicine.com/medline/citation/24436491/Long_term_oral_nutrition_supplementation_improves_outcomes_in_malnourished_patients_with_chronic_kidney_disease_on_hemodialysis_ L2 - https://doi.org/10.1177/0148607113517266 DB - PRIME DP - Unbound Medicine ER -