Tags

Type your tag names separated by a space and hit enter

Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia.
Schizophr Res 2014; 152(2-3):339-43SR

Abstract

BACKGROUND

Cognitive impairment is a core feature of schizophrenia. Some evidence suggests an association between cognition deficits and gray matter reductions. In this study, we investigated the relationship between cognitive performance and gray matter volumes in patients with treatment-naïve, first-episode schizophrenia.

METHOD

First-episode patients with treatment-naïve schizophrenia and healthy controls went through brain imaging scan using high resolution magnetic resonance imaging. A neuropsychological battery including 8 neurocognitive tests was used to assess cognitive function. Voxel-based methods were used for volumetric measure in the brain.

RESULTS

Fifty-one patients and 41 healthy controls were included in the analysis. Patients exhibited a poorer performance on all 7 cognitive function tests compared with healthy controls (ps<0.006). There were significant gray matter volume differences between the two groups in bilateral hippocampus gyri, right superior temporal gyrus, left fusiform gyrus and orbital inferior frontal gyri (FDR, ps<0.05). Within the schizophrenia group, multiple regression analysis demonstrated that poorer performance on the working memory, verbal learning and visual learning was associated with smaller hippocampal gray matter volume, and poorer executive function was associated with smaller left orbital inferior frontal gray matter volume after controlling for potential confounding variables (β ≥ 0.420, ps ≤ 0.010).

CONCLUSIONS

Our findings suggest that cognitive deficits are associated with hippocampal and orbital inferior frontal gray matter volume abnormalities in treatment-naïve, first-episode patients with schizophrenia.

Authors+Show Affiliations

Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, China.Key Laboratory for Neuroinformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, China.UMass Memorial Medical Center, University of Massachusetts Medical School, USA.Mental Health Center of Jiangxi Province, Nanchang, China.Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, China.Key Laboratory for Neuroinformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: Chenhf@uestc.edu.cn.Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, China. Electronic address: zhaojingpingcsu@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24439000

Citation

Guo, Xiaofeng, et al. "Hippocampal and Orbital Inferior Frontal Gray Matter Volume Abnormalities and Cognitive Deficit in Treatment-naive, First-episode Patients With Schizophrenia." Schizophrenia Research, vol. 152, no. 2-3, 2014, pp. 339-43.
Guo X, Li J, Wang J, et al. Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia. Schizophr Res. 2014;152(2-3):339-43.
Guo, X., Li, J., Wang, J., Fan, X., Hu, M., Shen, Y., ... Zhao, J. (2014). Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia. Schizophrenia Research, 152(2-3), pp. 339-43. doi:10.1016/j.schres.2013.12.015.
Guo X, et al. Hippocampal and Orbital Inferior Frontal Gray Matter Volume Abnormalities and Cognitive Deficit in Treatment-naive, First-episode Patients With Schizophrenia. Schizophr Res. 2014;152(2-3):339-43. PubMed PMID: 24439000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia. AU - Guo,Xiaofeng, AU - Li,Jun, AU - Wang,Juan, AU - Fan,Xiaoduo, AU - Hu,Maorong, AU - Shen,Yidong, AU - Chen,Huafu, AU - Zhao,Jingping, Y1 - 2014/01/15/ PY - 2013/08/08/received PY - 2013/12/01/revised PY - 2013/12/27/accepted PY - 2014/1/21/entrez PY - 2014/1/21/pubmed PY - 2014/9/24/medline KW - Cognitive function KW - First episode KW - Gray matter volume KW - Schizophrenia SP - 339 EP - 43 JF - Schizophrenia research JO - Schizophr. Res. VL - 152 IS - 2-3 N2 - BACKGROUND: Cognitive impairment is a core feature of schizophrenia. Some evidence suggests an association between cognition deficits and gray matter reductions. In this study, we investigated the relationship between cognitive performance and gray matter volumes in patients with treatment-naïve, first-episode schizophrenia. METHOD: First-episode patients with treatment-naïve schizophrenia and healthy controls went through brain imaging scan using high resolution magnetic resonance imaging. A neuropsychological battery including 8 neurocognitive tests was used to assess cognitive function. Voxel-based methods were used for volumetric measure in the brain. RESULTS: Fifty-one patients and 41 healthy controls were included in the analysis. Patients exhibited a poorer performance on all 7 cognitive function tests compared with healthy controls (ps<0.006). There were significant gray matter volume differences between the two groups in bilateral hippocampus gyri, right superior temporal gyrus, left fusiform gyrus and orbital inferior frontal gyri (FDR, ps<0.05). Within the schizophrenia group, multiple regression analysis demonstrated that poorer performance on the working memory, verbal learning and visual learning was associated with smaller hippocampal gray matter volume, and poorer executive function was associated with smaller left orbital inferior frontal gray matter volume after controlling for potential confounding variables (β ≥ 0.420, ps ≤ 0.010). CONCLUSIONS: Our findings suggest that cognitive deficits are associated with hippocampal and orbital inferior frontal gray matter volume abnormalities in treatment-naïve, first-episode patients with schizophrenia. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/24439000/Hippocampal_and_orbital_inferior_frontal_gray_matter_volume_abnormalities_and_cognitive_deficit_in_treatment_naive_first_episode_patients_with_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(13)00693-2 DB - PRIME DP - Unbound Medicine ER -