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Influence of apolipoprotein E gene polymorphism on development of type 2 diabetes mellitus in Chinese Han population: a meta-analysis of 29 studies.
Metabolism. 2014 Apr; 63(4):532-41.M

Abstract

OBJECTIVES

Published data regarding the association between apolipoprotein E (ApoE) gene polymorphism and type 2 diabetes mellitus (T2DM) risk in Chinese Han population were inconclusive. To derive a more precise estimation of the relationship between this variant and T2DM risk in Chinese Han population, we performed this meta-analysis.

DESIGN AND METHODS

A computerized literature search was conducted to identify the relevant studies from PubMed, EMbase, Web of Science, CBMdisc, CNKI, and Google Scholar. Additionally, hand searching of the references of identified articles was performed. All the statistical tests were performed using Stata 11.0.

RESULTS

A total of 29 articles with 4615 T2DM cases and 2867 controls were included in the present meta-analysis. The results showed evidence for significant association between ApoE gene polymorphism and T2DM risk (for ε2/ε3 vs. ε3/ε3: OR=1.37, 95% CI=1.12-1.68, P<0.01; for ε3/ε4 vs. ε3/ε3: OR=1.53, 95% CI=1.23-1.91, P<0.01; for ε4/ε4 vs. ε3/ε3: OR=1.86, 95% CI=1.22-2.84, P<0.01; for ε2 allele vs. ε3 allele: OR=1.28, 95% CI=1.08-1.52, P=0.01; for ε4 allele vs. ε3 allele: OR=1.43, 95% CI=1.22-1.68, P<0.01). In addition, significant association was also found between ApoE gene polymorphism and diabetic nephropathy (DN) risk.

CONCLUSIONS

The results of this meta-analysis suggest that the ApoE ε2 and ε4 alleles may be associated with increased risks of T2DM and DN in Chinese Han population. Additional well-designed genome-wide association studies are required to confirm these results.

Authors+Show Affiliations

Department of Emergency, Chinese PLA Air Force General Hospital, Haidian District, Beijing, China. Electronic address: shuaishuaijita@sohu.com.Department of Dermatology, Chinese PLA Air Force General Hospital, Haidian District, Beijing, China.Jinsong Sanatorium of Beijing Air Force, Beijing, China.Department of Emergency, Chinese PLA Air Force General Hospital, Haidian District, Beijing, China.Department of Emergency, Chinese PLA Air Force General Hospital, Haidian District, Beijing, China.Department of Emergency, Chinese PLA Air Force General Hospital, Haidian District, Beijing, China.Department of Emergency, Chinese PLA Air Force General Hospital, Haidian District, Beijing, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

24439487

Citation

Yin, Yan-Wei, et al. "Influence of Apolipoprotein E Gene Polymorphism On Development of Type 2 Diabetes Mellitus in Chinese Han Population: a Meta-analysis of 29 Studies." Metabolism: Clinical and Experimental, vol. 63, no. 4, 2014, pp. 532-41.
Yin YW, Qiao L, Sun QQ, et al. Influence of apolipoprotein E gene polymorphism on development of type 2 diabetes mellitus in Chinese Han population: a meta-analysis of 29 studies. Metabolism. 2014;63(4):532-41.
Yin, Y. W., Qiao, L., Sun, Q. Q., Hu, A. M., Liu, H. L., Wang, Q., & Hou, Z. Z. (2014). Influence of apolipoprotein E gene polymorphism on development of type 2 diabetes mellitus in Chinese Han population: a meta-analysis of 29 studies. Metabolism: Clinical and Experimental, 63(4), 532-41. https://doi.org/10.1016/j.metabol.2013.12.008
Yin YW, et al. Influence of Apolipoprotein E Gene Polymorphism On Development of Type 2 Diabetes Mellitus in Chinese Han Population: a Meta-analysis of 29 Studies. Metabolism. 2014;63(4):532-41. PubMed PMID: 24439487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of apolipoprotein E gene polymorphism on development of type 2 diabetes mellitus in Chinese Han population: a meta-analysis of 29 studies. AU - Yin,Yan-Wei, AU - Qiao,Li, AU - Sun,Qian-Qian, AU - Hu,Ai-Min, AU - Liu,Hong-Li, AU - Wang,Qi, AU - Hou,Zhi-Zhen, Y1 - 2013/12/18/ PY - 2013/08/27/received PY - 2013/12/10/revised PY - 2013/12/11/accepted PY - 2014/1/21/entrez PY - 2014/1/21/pubmed PY - 2014/5/21/medline KW - Apolipoprotein E KW - Meta-analysis KW - Polymorphism KW - Type 2 diabetes mellitus SP - 532 EP - 41 JF - Metabolism: clinical and experimental JO - Metabolism VL - 63 IS - 4 N2 - OBJECTIVES: Published data regarding the association between apolipoprotein E (ApoE) gene polymorphism and type 2 diabetes mellitus (T2DM) risk in Chinese Han population were inconclusive. To derive a more precise estimation of the relationship between this variant and T2DM risk in Chinese Han population, we performed this meta-analysis. DESIGN AND METHODS: A computerized literature search was conducted to identify the relevant studies from PubMed, EMbase, Web of Science, CBMdisc, CNKI, and Google Scholar. Additionally, hand searching of the references of identified articles was performed. All the statistical tests were performed using Stata 11.0. RESULTS: A total of 29 articles with 4615 T2DM cases and 2867 controls were included in the present meta-analysis. The results showed evidence for significant association between ApoE gene polymorphism and T2DM risk (for ε2/ε3 vs. ε3/ε3: OR=1.37, 95% CI=1.12-1.68, P<0.01; for ε3/ε4 vs. ε3/ε3: OR=1.53, 95% CI=1.23-1.91, P<0.01; for ε4/ε4 vs. ε3/ε3: OR=1.86, 95% CI=1.22-2.84, P<0.01; for ε2 allele vs. ε3 allele: OR=1.28, 95% CI=1.08-1.52, P=0.01; for ε4 allele vs. ε3 allele: OR=1.43, 95% CI=1.22-1.68, P<0.01). In addition, significant association was also found between ApoE gene polymorphism and diabetic nephropathy (DN) risk. CONCLUSIONS: The results of this meta-analysis suggest that the ApoE ε2 and ε4 alleles may be associated with increased risks of T2DM and DN in Chinese Han population. Additional well-designed genome-wide association studies are required to confirm these results. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/24439487/Influence_of_apolipoprotein_E_gene_polymorphism_on_development_of_type_2_diabetes_mellitus_in_Chinese_Han_population:_a_meta_analysis_of_29_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(13)00421-6 DB - PRIME DP - Unbound Medicine ER -