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Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with moderate and severe traumatic brain injury.
Neurol India. 2013 Nov-Dec; 61(6):606-9.NI

Abstract

OBJECTIVE

In this study, we investigated matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) in cerebrospinal fluid (CSF) and plasma of traumatic brain injury (TBI) patients.

PATIENTS AND METHODS

A total of 30 patients with moderate and severe TBI and 15 age-matched controls were enrolled in this study. Plasma and CSF samples were collected within 24 h (as the initial value), at 72 and 120 h post injury. CSF and plasma MMP-9, MMP-2, TIMP-1 and TIMP-2 were estimated using ELISA. Different levels of these indexes were compared in the two groups and further investigated the correlation between each other.

RESULTS

There was a significant elevation in the levels of the initial MMP-9 in the CSF (P < 0.05), which lasted for 72 h post injury. TIMP-1 kept increasing within 120 h post injury and it was different compared with TIMP-1 at 24 and 72 h post injury. Plasma levels of MMP-9, MMP-2, TIMP-1 and TIMP-2 in TBI patients were also significantly different from those in controls. Furthermore the CSF MMP-9 in patients with severe TBI was higher than that in patients with moderate TBI. In addition, there was a positive relationship between the initial MMP-9 and TIMP-1 at 120 h post injury (r = 0.614, P < 0.01).

CONCLUSION

MMPs and TIMPs are increased in both CSF and plasma of TBI patients. TIMP-1 has a positive correlation with MMP-9 and the initial MMP-9 is associated with the neurological outcomes.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Neuroscience, College of Life Science, Hebei University, Hebei Province, China.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24441327

Citation

Zheng, Kebin, et al. "Matrix Metalloproteinases and Their Tissue Inhibitors in Serum and Cerebrospinal Fluid of Patients With Moderate and Severe Traumatic Brain Injury." Neurology India, vol. 61, no. 6, 2013, pp. 606-9.
Zheng K, Li C, Shan X, et al. Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with moderate and severe traumatic brain injury. Neurol India. 2013;61(6):606-9.
Zheng, K., Li, C., Shan, X., Liu, H., Fan, W., Wang, Z., & Zheng, P. (2013). Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with moderate and severe traumatic brain injury. Neurology India, 61(6), 606-9. https://doi.org/10.4103/0028-3886.125258
Zheng K, et al. Matrix Metalloproteinases and Their Tissue Inhibitors in Serum and Cerebrospinal Fluid of Patients With Moderate and Severe Traumatic Brain Injury. Neurol India. 2013 Nov-Dec;61(6):606-9. PubMed PMID: 24441327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with moderate and severe traumatic brain injury. AU - Zheng,Kebin, AU - Li,Chunhui, AU - Shan,Xiaosong, AU - Liu,Haipeng, AU - Fan,Wufang, AU - Wang,Zhenshan, AU - Zheng,Ping, PY - 2014/1/21/entrez PY - 2014/1/21/pubmed PY - 2014/3/26/medline SP - 606 EP - 9 JF - Neurology India JO - Neurol India VL - 61 IS - 6 N2 - OBJECTIVE: In this study, we investigated matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) in cerebrospinal fluid (CSF) and plasma of traumatic brain injury (TBI) patients. PATIENTS AND METHODS: A total of 30 patients with moderate and severe TBI and 15 age-matched controls were enrolled in this study. Plasma and CSF samples were collected within 24 h (as the initial value), at 72 and 120 h post injury. CSF and plasma MMP-9, MMP-2, TIMP-1 and TIMP-2 were estimated using ELISA. Different levels of these indexes were compared in the two groups and further investigated the correlation between each other. RESULTS: There was a significant elevation in the levels of the initial MMP-9 in the CSF (P < 0.05), which lasted for 72 h post injury. TIMP-1 kept increasing within 120 h post injury and it was different compared with TIMP-1 at 24 and 72 h post injury. Plasma levels of MMP-9, MMP-2, TIMP-1 and TIMP-2 in TBI patients were also significantly different from those in controls. Furthermore the CSF MMP-9 in patients with severe TBI was higher than that in patients with moderate TBI. In addition, there was a positive relationship between the initial MMP-9 and TIMP-1 at 120 h post injury (r = 0.614, P < 0.01). CONCLUSION: MMPs and TIMPs are increased in both CSF and plasma of TBI patients. TIMP-1 has a positive correlation with MMP-9 and the initial MMP-9 is associated with the neurological outcomes. SN - 0028-3886 UR - https://www.unboundmedicine.com/medline/citation/24441327/Matrix_metalloproteinases_and_their_tissue_inhibitors_in_serum_and_cerebrospinal_fluid_of_patients_with_moderate_and_severe_traumatic_brain_injury_ L2 - http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2013;volume=61;issue=6;spage=606;epage=609;aulast=Zheng DB - PRIME DP - Unbound Medicine ER -