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Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors.
Cancer Causes Control. 2014 Mar; 25(3):375-83.CC

Abstract

PURPOSE

Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but parental, fetal, and early life exposures are likely to be important given the early age at diagnosis of many cases. We aimed to investigate whether parents' diagnostic radiological procedures before conception, in the mother during pregnancy or the child's procedures were associated with an increased risk of CBT.

METHODS

This population-based case-control study was conducted between 2005 and 2010. Cases were identified through all ten Australian pediatric oncology centers, and controls via nationwide random-digit dialing; frequency-matched to cases on age, sex and state of residence. Information on radiological exposures in the time periods of interest was obtained for 306 case and 950 control families through mailed questionnaires. Analysis used unconditional logistic regression, adjusting for matching variables and potential confounders.

RESULTS

We found no evidence of positive associations between risk of CBT overall and childhood or parental pre-pregnancy radiological procedures. Increased ORs for high-grade gliomas associated with childhood radiological procedures were based on small numbers and may be due to chance.

CONCLUSIONS

Given the evidence for an increased risk of CBT in cohort studies of computed tomography (CT) in childhood, the lack of such an association in our study may be due to the reduced intensity of CTs after 2001. Future research to investigate the safety of fetal exposure to more intense procedures like CT scans is needed.

Authors+Show Affiliations

Telethon Institute for Child Health Research, University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia, lizm@ichr.uwa.edu.au.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24445596

Citation

Milne, Elizabeth, et al. "Childhood and Parental Diagnostic Radiological Procedures and Risk of Childhood Brain Tumors." Cancer Causes & Control : CCC, vol. 25, no. 3, 2014, pp. 375-83.
Milne E, Greenop KR, Fritschi L, et al. Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors. Cancer Causes Control. 2014;25(3):375-83.
Milne, E., Greenop, K. R., Fritschi, L., Attia, J., Bailey, H. D., Scott, R. J., Ashton, L. J., Smibert, E., & Armstrong, B. K. (2014). Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors. Cancer Causes & Control : CCC, 25(3), 375-83. https://doi.org/10.1007/s10552-014-0338-x
Milne E, et al. Childhood and Parental Diagnostic Radiological Procedures and Risk of Childhood Brain Tumors. Cancer Causes Control. 2014;25(3):375-83. PubMed PMID: 24445596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood and parental diagnostic radiological procedures and risk of childhood brain tumors. AU - Milne,Elizabeth, AU - Greenop,Kathryn R, AU - Fritschi,Lin, AU - Attia,John, AU - Bailey,Helen D, AU - Scott,Rodney J, AU - Ashton,Lesley J, AU - Smibert,Elizabeth, AU - Armstrong,Bruce K, Y1 - 2014/01/21/ PY - 2013/08/22/received PY - 2014/01/08/accepted PY - 2014/1/22/entrez PY - 2014/1/22/pubmed PY - 2014/11/14/medline SP - 375 EP - 83 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 25 IS - 3 N2 - PURPOSE: Childhood brain tumors (CBT) are the second most common type of childhood cancer and the leading cause of childhood cancer mortality. Few causes of CBT are known, but parental, fetal, and early life exposures are likely to be important given the early age at diagnosis of many cases. We aimed to investigate whether parents' diagnostic radiological procedures before conception, in the mother during pregnancy or the child's procedures were associated with an increased risk of CBT. METHODS: This population-based case-control study was conducted between 2005 and 2010. Cases were identified through all ten Australian pediatric oncology centers, and controls via nationwide random-digit dialing; frequency-matched to cases on age, sex and state of residence. Information on radiological exposures in the time periods of interest was obtained for 306 case and 950 control families through mailed questionnaires. Analysis used unconditional logistic regression, adjusting for matching variables and potential confounders. RESULTS: We found no evidence of positive associations between risk of CBT overall and childhood or parental pre-pregnancy radiological procedures. Increased ORs for high-grade gliomas associated with childhood radiological procedures were based on small numbers and may be due to chance. CONCLUSIONS: Given the evidence for an increased risk of CBT in cohort studies of computed tomography (CT) in childhood, the lack of such an association in our study may be due to the reduced intensity of CTs after 2001. Future research to investigate the safety of fetal exposure to more intense procedures like CT scans is needed. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/24445596/Childhood_and_parental_diagnostic_radiological_procedures_and_risk_of_childhood_brain_tumors_ L2 - https://doi.org/10.1007/s10552-014-0338-x DB - PRIME DP - Unbound Medicine ER -