TY - JOUR T1 - Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens. AU - Guenin-Macé,Laure, AU - Oldenburg,Reid, AU - Chrétien,Fabrice, AU - Demangel,Caroline, Y1 - 2014/01/21/ PY - 2013/07/09/received PY - 2014/01/10/accepted PY - 2014/01/07/revised PY - 2014/1/22/entrez PY - 2014/1/22/pubmed PY - 2014/8/19/medline SP - 2443 EP - 50 JF - Cellular and molecular life sciences : CMLS JO - Cell Mol Life Sci VL - 71 IS - 13 N2 - Skin ulcers are most commonly due to circulatory or metabolic disorders and are a major public health concern. In developed countries, chronic wounds affect more than 1 % of the population and their incidence is expected to follow those observed for diabetes and obesity. In tropical and subtropical countries, an additional issue is the occurrence of ulcers of infectious origins with diverse etiologies. While the severity of cutaneous Leishmaniasis correlates with protective immune responses, Buruli ulcers caused by Mycobacterium ulcerans develop in the absence of major inflammation. Based on these two examples, this review aims to demonstrate how studies on microorganism-provoked wounds can provide insight into the molecular mechanisms controlling skin integrity. We highlight the potential interest of a mouse model of non-inflammatory skin ulceration caused by intradermal injection of mycolactone, an original lipid toxin with ulcerative and immunosuppressive properties produced by M. ulcerans. SN - 1420-9071 UR - https://www.unboundmedicine.com/medline/citation/24445815/Pathogenesis_of_skin_ulcers:_lessons_from_the_Mycobacterium_ulcerans_and_Leishmania_spp__pathogens_ DB - PRIME DP - Unbound Medicine ER -