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Chloral hydrate, chloral hydrate--promethazine and chloral hydrate -hydroxyzine efficacy in electroencephalography sedation.
Indian J Pediatr 2014; 81(6):541-6IJ

Abstract

OBJECTIVE

To compare efficacy and safety of chloral hydrate (CH), chloral hydrate and promethazine (CH + P) and chloral hydrate and hydroxyzine (CH + H) in electroencephalography (EEG) sedation.

METHODS

In a parallel single-blinded randomized clinical trial, ninety 1-7 y-old uncooperative kids who were referred to Pediatric Neurology Clinic of Shahid Sadoughi University, Yazd, Iran from April through August 2012, were randomly assigned to receive 40 mg/kg of chloral hydrate or 40 mg/kg of chloral hydrate and 1 mg/kg of promethazine or 40 mg/kg of chloral hydrate and 2 mg/kg of hydroxyzine. The primary endpoint was efficacy in sufficient sedation (obtaining four Ramsay sedation score) and successful completion of EEG. Secondary endpoint was clinical adverse events.

RESULTS

Thirty nine girls (43.3 %) and 51 boys (56.7 %) with mean age of 3.34 ± 1.47 y were assessed. Sufficient sedation and completion of EEG were achieved in 70 % (N = 21) of chloral hydrate group, in 83.3 % (N = 25) of CH + H group and in 96.7 % (N = 29) of CH + P group (p = 0.02). Mild clinical adverse events including vomiting [16.7 % (N = 5) in CH, 6.7 % (N = 2) in CH + P, 6.7 % (N = 2) in CH + H], agitation in 3.3 % of CH + P (N = 1) group and mild transient hypotension in 3.3 % of CH + H (N = 1) group occurred. Safety of these three sedation regimens was not statistically significant different (p = 0.14).

CONCLUSIONS

Combination of chloral hydrate-antihistamines can be used as the most effective and safe sedation regimen in drug induced sleep electroencephalography of kids.

Authors+Show Affiliations

Department of Pediatrics, Growth Disorders of Children Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24445981

Citation

Fallah, Razieh, et al. "Chloral Hydrate, Chloral Hydrate--promethazine and Chloral Hydrate -hydroxyzine Efficacy in Electroencephalography Sedation." Indian Journal of Pediatrics, vol. 81, no. 6, 2014, pp. 541-6.
Fallah R, Alaei A, Akhavan Karbasi S, et al. Chloral hydrate, chloral hydrate--promethazine and chloral hydrate -hydroxyzine efficacy in electroencephalography sedation. Indian J Pediatr. 2014;81(6):541-6.
Fallah, R., Alaei, A., Akhavan Karbasi, S., & Shajari, A. (2014). Chloral hydrate, chloral hydrate--promethazine and chloral hydrate -hydroxyzine efficacy in electroencephalography sedation. Indian Journal of Pediatrics, 81(6), pp. 541-6. doi:10.1007/s12098-013-1298-y.
Fallah R, et al. Chloral Hydrate, Chloral Hydrate--promethazine and Chloral Hydrate -hydroxyzine Efficacy in Electroencephalography Sedation. Indian J Pediatr. 2014;81(6):541-6. PubMed PMID: 24445981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chloral hydrate, chloral hydrate--promethazine and chloral hydrate -hydroxyzine efficacy in electroencephalography sedation. AU - Fallah,Razieh, AU - Alaei,Ali, AU - Akhavan Karbasi,Sedighah, AU - Shajari,Ahmad, Y1 - 2014/01/21/ PY - 2013/03/27/received PY - 2013/10/30/accepted PY - 2014/1/22/entrez PY - 2014/1/22/pubmed PY - 2015/9/22/medline SP - 541 EP - 6 JF - Indian journal of pediatrics JO - Indian J Pediatr VL - 81 IS - 6 N2 - OBJECTIVE: To compare efficacy and safety of chloral hydrate (CH), chloral hydrate and promethazine (CH + P) and chloral hydrate and hydroxyzine (CH + H) in electroencephalography (EEG) sedation. METHODS: In a parallel single-blinded randomized clinical trial, ninety 1-7 y-old uncooperative kids who were referred to Pediatric Neurology Clinic of Shahid Sadoughi University, Yazd, Iran from April through August 2012, were randomly assigned to receive 40 mg/kg of chloral hydrate or 40 mg/kg of chloral hydrate and 1 mg/kg of promethazine or 40 mg/kg of chloral hydrate and 2 mg/kg of hydroxyzine. The primary endpoint was efficacy in sufficient sedation (obtaining four Ramsay sedation score) and successful completion of EEG. Secondary endpoint was clinical adverse events. RESULTS: Thirty nine girls (43.3 %) and 51 boys (56.7 %) with mean age of 3.34 ± 1.47 y were assessed. Sufficient sedation and completion of EEG were achieved in 70 % (N = 21) of chloral hydrate group, in 83.3 % (N = 25) of CH + H group and in 96.7 % (N = 29) of CH + P group (p = 0.02). Mild clinical adverse events including vomiting [16.7 % (N = 5) in CH, 6.7 % (N = 2) in CH + P, 6.7 % (N = 2) in CH + H], agitation in 3.3 % of CH + P (N = 1) group and mild transient hypotension in 3.3 % of CH + H (N = 1) group occurred. Safety of these three sedation regimens was not statistically significant different (p = 0.14). CONCLUSIONS: Combination of chloral hydrate-antihistamines can be used as the most effective and safe sedation regimen in drug induced sleep electroencephalography of kids. SN - 0973-7693 UR - https://www.unboundmedicine.com/medline/citation/24445981/Chloral_hydrate_chloral_hydrate__promethazine_and_chloral_hydrate__hydroxyzine_efficacy_in_electroencephalography_sedation_ L2 - https://dx.doi.org/10.1007/s12098-013-1298-y DB - PRIME DP - Unbound Medicine ER -