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Intranasal dexmedetomidine following failed chloral hydrate sedation in children.
Anaesthesia 2014; 69(3):240-4A

Abstract

Chloral hydrate is the most commonly used sedative for paediatric diagnostic procedures in China with a success rate of around 80%. Intranasal dexmedetomidine is used for rescue sedation in our centre. This prospective investigation evaluated 213 children aged one month to 10 years who were not adequately sedated following administration of chloral hydrate. Children were randomly assigned to receive rescue intranasal dexmedetomidine at 1 μg.kg(-1) (group 1), 1.5 μg.kg(-1) (group 2) or 2 μg.kg(-1) (group 3). The sedation level was assessed every 10 min using a modified observer's assessment of alertness/sedation scale. Successful rescue sedation in groups 1, 2 and 3 were 56 (83.6%), 66 (89.2%) and 51 (96.2%), respectively. Increasing the rescue dose was associated with an increased success rate with an odds ratio of 4.12 (95% CI 1.13-14.98), p = 0.032. We conclude that intranasal dexmedetomidine is effective for sedation in children who do not respond to chloral hydrate.

Authors+Show Affiliations

Department of Anaesthesiology, Guangzhou Women and Children's Medical Centre of Guangzhou Medical University, Guangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

24447296

Citation

Li, B L., et al. "Intranasal Dexmedetomidine Following Failed Chloral Hydrate Sedation in Children." Anaesthesia, vol. 69, no. 3, 2014, pp. 240-4.
Li BL, Yuen VM, Song XR, et al. Intranasal dexmedetomidine following failed chloral hydrate sedation in children. Anaesthesia. 2014;69(3):240-4.
Li, B. L., Yuen, V. M., Song, X. R., Ye, J., Ni, J., Huang, J. X., & Irwin, M. G. (2014). Intranasal dexmedetomidine following failed chloral hydrate sedation in children. Anaesthesia, 69(3), pp. 240-4. doi:10.1111/anae.12533.
Li BL, et al. Intranasal Dexmedetomidine Following Failed Chloral Hydrate Sedation in Children. Anaesthesia. 2014;69(3):240-4. PubMed PMID: 24447296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intranasal dexmedetomidine following failed chloral hydrate sedation in children. AU - Li,B L, AU - Yuen,V M, AU - Song,X R, AU - Ye,J, AU - Ni,J, AU - Huang,J X, AU - Irwin,M G, Y1 - 2014/01/21/ PY - 2013/11/02/accepted PY - 2014/1/23/entrez PY - 2014/1/23/pubmed PY - 2014/4/9/medline SP - 240 EP - 4 JF - Anaesthesia JO - Anaesthesia VL - 69 IS - 3 N2 - Chloral hydrate is the most commonly used sedative for paediatric diagnostic procedures in China with a success rate of around 80%. Intranasal dexmedetomidine is used for rescue sedation in our centre. This prospective investigation evaluated 213 children aged one month to 10 years who were not adequately sedated following administration of chloral hydrate. Children were randomly assigned to receive rescue intranasal dexmedetomidine at 1 μg.kg(-1) (group 1), 1.5 μg.kg(-1) (group 2) or 2 μg.kg(-1) (group 3). The sedation level was assessed every 10 min using a modified observer's assessment of alertness/sedation scale. Successful rescue sedation in groups 1, 2 and 3 were 56 (83.6%), 66 (89.2%) and 51 (96.2%), respectively. Increasing the rescue dose was associated with an increased success rate with an odds ratio of 4.12 (95% CI 1.13-14.98), p = 0.032. We conclude that intranasal dexmedetomidine is effective for sedation in children who do not respond to chloral hydrate. SN - 1365-2044 UR - https://www.unboundmedicine.com/medline/citation/24447296/Intranasal_dexmedetomidine_following_failed_chloral_hydrate_sedation_in_children_ L2 - https://doi.org/10.1111/anae.12533 DB - PRIME DP - Unbound Medicine ER -