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Evaluation of the repellent effects of Nepeta parnassica extract, essential oil, and its major nepetalactone metabolite against mosquitoes.
Parasitol Res. 2014 Mar; 113(3):1127-34.PR

Abstract

The dichloromethane-methanol extract, the essential oil obtained by hydrodistillation from Nepeta parnassica, and the isolated 4aα,7α,7aβ-nepetalactone were evaluated for their repellent effect against the mosquitoes Aedes (Stegomyia) cretinus Edwards and Culex pipiens pipiens biotype molestus Forskål. The chemical analysis of N. parnassica essential oil, dominated by oxygenated monoterpenes (87 %), revealed 4aα,7α,7aβ-nepetalactone (36.8%), 1,8-cineole (25.5%), and 4aα,7β,7aβ-nepetalactone (11.1%) as the major constituents. The results of the insect bioassays showed that the essential oil and the dichloromethane-methanol extract of N. parnassica were very active against Aedes cretinus for up to 3 h and against Culex pipiens for up to 2 h post application. The isolated 4aα,7α,7aβ-nepetalactone showed very high mosquito repellency for periods of at least 2 h against both species.

Authors+Show Affiliations

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimioupoli Zographou, 157 71, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24449446

Citation

Gkinis, G, et al. "Evaluation of the Repellent Effects of Nepeta Parnassica Extract, Essential Oil, and Its Major Nepetalactone Metabolite Against Mosquitoes." Parasitology Research, vol. 113, no. 3, 2014, pp. 1127-34.
Gkinis G, Michaelakis A, Koliopoulos G, et al. Evaluation of the repellent effects of Nepeta parnassica extract, essential oil, and its major nepetalactone metabolite against mosquitoes. Parasitol Res. 2014;113(3):1127-34.
Gkinis, G., Michaelakis, A., Koliopoulos, G., Ioannou, E., Tzakou, O., & Roussis, V. (2014). Evaluation of the repellent effects of Nepeta parnassica extract, essential oil, and its major nepetalactone metabolite against mosquitoes. Parasitology Research, 113(3), 1127-34. https://doi.org/10.1007/s00436-013-3750-3
Gkinis G, et al. Evaluation of the Repellent Effects of Nepeta Parnassica Extract, Essential Oil, and Its Major Nepetalactone Metabolite Against Mosquitoes. Parasitol Res. 2014;113(3):1127-34. PubMed PMID: 24449446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the repellent effects of Nepeta parnassica extract, essential oil, and its major nepetalactone metabolite against mosquitoes. AU - Gkinis,G, AU - Michaelakis,A, AU - Koliopoulos,G, AU - Ioannou,E, AU - Tzakou,O, AU - Roussis,V, Y1 - 2014/01/22/ PY - 2013/12/16/received PY - 2013/12/26/accepted PY - 2014/1/23/entrez PY - 2014/1/23/pubmed PY - 2014/8/12/medline SP - 1127 EP - 34 JF - Parasitology research JO - Parasitol Res VL - 113 IS - 3 N2 - The dichloromethane-methanol extract, the essential oil obtained by hydrodistillation from Nepeta parnassica, and the isolated 4aα,7α,7aβ-nepetalactone were evaluated for their repellent effect against the mosquitoes Aedes (Stegomyia) cretinus Edwards and Culex pipiens pipiens biotype molestus Forskål. The chemical analysis of N. parnassica essential oil, dominated by oxygenated monoterpenes (87 %), revealed 4aα,7α,7aβ-nepetalactone (36.8%), 1,8-cineole (25.5%), and 4aα,7β,7aβ-nepetalactone (11.1%) as the major constituents. The results of the insect bioassays showed that the essential oil and the dichloromethane-methanol extract of N. parnassica were very active against Aedes cretinus for up to 3 h and against Culex pipiens for up to 2 h post application. The isolated 4aα,7α,7aβ-nepetalactone showed very high mosquito repellency for periods of at least 2 h against both species. SN - 1432-1955 UR - https://www.unboundmedicine.com/medline/citation/24449446/Evaluation_of_the_repellent_effects_of_Nepeta_parnassica_extract_essential_oil_and_its_major_nepetalactone_metabolite_against_mosquitoes_ L2 - https://dx.doi.org/10.1007/s00436-013-3750-3 DB - PRIME DP - Unbound Medicine ER -