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Breast-specific gamma imaging for the detection of breast cancer in dense versus nondense breasts.
AJR Am J Roentgenol. 2014 Feb; 202(2):293-8.AA

Abstract

OBJECTIVE

The purpose of this study was to evaluate the sensitivity of breast-specific gamma imaging (BSGI) for the detection of breast cancer in dense versus nondense breasts.

MATERIALS AND METHODS

This was a retrospective study of 341 women with biopsy-proven breast cancer diagnosed from January 2004 to August 2009 who underwent BSGI before surgical excision. Patients with predominantly fatty replaced (BI-RADS density 1) or scattered fibroglandular tissue (BI-RADS density 2) breasts were classified as nondense, and those with heterogeneously dense (BI-RADS density 3) or extremely dense tissue (BIRADS density 4) were classified as dense. BSGI examinations exhibiting focal increased radiotracer uptake in the area of biopsy-proven cancer were classified as positive according to BSGI reports in the medical record. The sensitivity of BSGI was calculated using Microsoft Excel 2003. Between-group differences were evaluated statistically using the Student t test for continuous variables and the chi-square test for categoric variables, with p < 0.05 considered statistically significant.

RESULTS

The overall sensitivity of BSGI for breast cancer detection was 95.4%. Positive BSGI examinations were present in 136 of 142 nondense breast cancers and 195 of 205 dense breast cancers, for sensitivities of 95.8% and 95.1%, respectively. There was no significant difference in BSGI breast cancer detection and parenchymal breast density (p = 0.459).

CONCLUSION

BSGI has high sensitivities for the detection of breast cancer in women with dense and nondense breasts and is an effective adjunct imaging modality in women with both dense and nondense breasts.

Authors+Show Affiliations

1 Breast Imaging and Interventional Center, Department of Radiology, The George Washington University, 2150 Pennsylvania Ave NW, Washington, DC 20037.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24450668

Citation

Rechtman, Lauren R., et al. "Breast-specific Gamma Imaging for the Detection of Breast Cancer in Dense Versus Nondense Breasts." AJR. American Journal of Roentgenology, vol. 202, no. 2, 2014, pp. 293-8.
Rechtman LR, Lenihan MJ, Lieberman JH, et al. Breast-specific gamma imaging for the detection of breast cancer in dense versus nondense breasts. AJR Am J Roentgenol. 2014;202(2):293-8.
Rechtman, L. R., Lenihan, M. J., Lieberman, J. H., Teal, C. B., Torrente, J., Rapelyea, J. A., & Brem, R. F. (2014). Breast-specific gamma imaging for the detection of breast cancer in dense versus nondense breasts. AJR. American Journal of Roentgenology, 202(2), 293-8. https://doi.org/10.2214/AJR.13.11585
Rechtman LR, et al. Breast-specific Gamma Imaging for the Detection of Breast Cancer in Dense Versus Nondense Breasts. AJR Am J Roentgenol. 2014;202(2):293-8. PubMed PMID: 24450668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-specific gamma imaging for the detection of breast cancer in dense versus nondense breasts. AU - Rechtman,Lauren R, AU - Lenihan,Megan J, AU - Lieberman,Jennifer H, AU - Teal,Christine B, AU - Torrente,Jessica, AU - Rapelyea,Jocelyn A, AU - Brem,Rachel F, PY - 2014/1/24/entrez PY - 2014/1/24/pubmed PY - 2014/4/25/medline SP - 293 EP - 8 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 202 IS - 2 N2 - OBJECTIVE: The purpose of this study was to evaluate the sensitivity of breast-specific gamma imaging (BSGI) for the detection of breast cancer in dense versus nondense breasts. MATERIALS AND METHODS: This was a retrospective study of 341 women with biopsy-proven breast cancer diagnosed from January 2004 to August 2009 who underwent BSGI before surgical excision. Patients with predominantly fatty replaced (BI-RADS density 1) or scattered fibroglandular tissue (BI-RADS density 2) breasts were classified as nondense, and those with heterogeneously dense (BI-RADS density 3) or extremely dense tissue (BIRADS density 4) were classified as dense. BSGI examinations exhibiting focal increased radiotracer uptake in the area of biopsy-proven cancer were classified as positive according to BSGI reports in the medical record. The sensitivity of BSGI was calculated using Microsoft Excel 2003. Between-group differences were evaluated statistically using the Student t test for continuous variables and the chi-square test for categoric variables, with p < 0.05 considered statistically significant. RESULTS: The overall sensitivity of BSGI for breast cancer detection was 95.4%. Positive BSGI examinations were present in 136 of 142 nondense breast cancers and 195 of 205 dense breast cancers, for sensitivities of 95.8% and 95.1%, respectively. There was no significant difference in BSGI breast cancer detection and parenchymal breast density (p = 0.459). CONCLUSION: BSGI has high sensitivities for the detection of breast cancer in women with dense and nondense breasts and is an effective adjunct imaging modality in women with both dense and nondense breasts. SN - 1546-3141 UR - https://www.unboundmedicine.com/medline/citation/24450668/Breast_specific_gamma_imaging_for_the_detection_of_breast_cancer_in_dense_versus_nondense_breasts_ L2 - https://www.ajronline.org/doi/10.2214/AJR.13.11585 DB - PRIME DP - Unbound Medicine ER -