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Early atherogenesis and visceral fat in obese adolescents.
Int J Obes (Lond). 2014 Jul; 38(7):954-8.IJ

Abstract

BACKGROUND/OBJECTIVES

Little information is available as to the cause of increased thickening of the intima-media of the carotid artery (cIMT) in the pediatric population. Therefore, cIMT was compared in obese adolescents and normal-weight controls, and associations between cIMT and lipid and non-lipid cardiovascular risk factors were assessed.

SUBJECTS/METHODS

Subjects included 61 obese non-diabetic male and female volunteers aged 12-18 years inclusive with a body mass index (BMI) >95th percentile for age and 2-h blood glucose <200 mg dl(-1) matched to 25 normal-weight control volunteers with normal glucose levels. Each subject underwent a 2-h glucose tolerance test and measurement of hemoglobin A1c, ultrasensitive C-reactive protein, fasting insulin, blood lipids, visceral, subcutaneous abdominal and hepatic fat, and cIMT.

RESULTS

Maximum cIMT was 0.647±0.075 mm in the obese subjects versus 0.579±0.027 mm in normal-weight controls (P<0.001). There was no difference in maximum cIMT between male and female subjects. There were significant correlations between maximum cIMT and BMI z-score, 2-h glucose, fasting insulin, homeostasis model assessment (HOMA), total low-density lipoprotein (LDL) cholesterol, very LDL cholesterol, high-density lipoprotein (HDL) cholesterol, HDL2 cholesterol, HDL3 cholesterol, triglycerides, remnant lipoprotein cholesterol, intermediate-density lipoprotein cholesterol, lipoprotein(a), apoprotein B100, abdominal subcutaneous fat volume, visceral fat volume and hepatic phase difference. On multiple regression analysis, visceral fat was the most significant predictor of maximum cIMT. Two-hour blood glucose, HOMA and systolic blood pressure were also significant predictors of maximum cIMT.

CONCLUSIONS

cIMT was increased in the obese adolescents compared with the normal-weight-matched controls. Visceral fat was a key predictor of arterial wall thickening in these subjects. The results suggest that the focus of cardiovascular disease prevention in the adolescent obese should be visceral obesity, and not blood lipids or lipid subclasses.

Authors+Show Affiliations

Department of Pediatrics, Lehigh Valley Health Network, Allentown, PA, USA.Department of Radiology, Lehigh Valley Health Network, Allentown, PA, USA.Scripps Clinic, Division of Cardiovascular Medicine, La Jolla, CA, USA.Network Office of Research and Innovation, Lehigh Valley Health Network, Allentown, PA, USA.No affiliation info availableNo affiliation info availableCardiovascular Research Institute, Lehigh Valley Health Network, Allentown, PA, USA.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24451186

Citation

Slyper, A H., et al. "Early Atherogenesis and Visceral Fat in Obese Adolescents." International Journal of Obesity (2005), vol. 38, no. 7, 2014, pp. 954-8.
Slyper AH, Rosenberg H, Kabra A, et al. Early atherogenesis and visceral fat in obese adolescents. Int J Obes (Lond). 2014;38(7):954-8.
Slyper, A. H., Rosenberg, H., Kabra, A., Weiss, M. J., Blech, B., Gensler, S., & Matsumura, M. (2014). Early atherogenesis and visceral fat in obese adolescents. International Journal of Obesity (2005), 38(7), 954-8. https://doi.org/10.1038/ijo.2014.11
Slyper AH, et al. Early Atherogenesis and Visceral Fat in Obese Adolescents. Int J Obes (Lond). 2014;38(7):954-8. PubMed PMID: 24451186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early atherogenesis and visceral fat in obese adolescents. AU - Slyper,A H, AU - Rosenberg,H, AU - Kabra,A, AU - Weiss,M J, AU - Blech,B, AU - Gensler,S, AU - Matsumura,M, Y1 - 2014/01/23/ PY - 2013/09/01/received PY - 2013/11/26/revised PY - 2013/12/08/accepted PY - 2014/1/24/entrez PY - 2014/1/24/pubmed PY - 2015/4/2/medline SP - 954 EP - 8 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 38 IS - 7 N2 - BACKGROUND/OBJECTIVES: Little information is available as to the cause of increased thickening of the intima-media of the carotid artery (cIMT) in the pediatric population. Therefore, cIMT was compared in obese adolescents and normal-weight controls, and associations between cIMT and lipid and non-lipid cardiovascular risk factors were assessed. SUBJECTS/METHODS: Subjects included 61 obese non-diabetic male and female volunteers aged 12-18 years inclusive with a body mass index (BMI) >95th percentile for age and 2-h blood glucose <200 mg dl(-1) matched to 25 normal-weight control volunteers with normal glucose levels. Each subject underwent a 2-h glucose tolerance test and measurement of hemoglobin A1c, ultrasensitive C-reactive protein, fasting insulin, blood lipids, visceral, subcutaneous abdominal and hepatic fat, and cIMT. RESULTS: Maximum cIMT was 0.647±0.075 mm in the obese subjects versus 0.579±0.027 mm in normal-weight controls (P<0.001). There was no difference in maximum cIMT between male and female subjects. There were significant correlations between maximum cIMT and BMI z-score, 2-h glucose, fasting insulin, homeostasis model assessment (HOMA), total low-density lipoprotein (LDL) cholesterol, very LDL cholesterol, high-density lipoprotein (HDL) cholesterol, HDL2 cholesterol, HDL3 cholesterol, triglycerides, remnant lipoprotein cholesterol, intermediate-density lipoprotein cholesterol, lipoprotein(a), apoprotein B100, abdominal subcutaneous fat volume, visceral fat volume and hepatic phase difference. On multiple regression analysis, visceral fat was the most significant predictor of maximum cIMT. Two-hour blood glucose, HOMA and systolic blood pressure were also significant predictors of maximum cIMT. CONCLUSIONS: cIMT was increased in the obese adolescents compared with the normal-weight-matched controls. Visceral fat was a key predictor of arterial wall thickening in these subjects. The results suggest that the focus of cardiovascular disease prevention in the adolescent obese should be visceral obesity, and not blood lipids or lipid subclasses. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/24451186/Early_atherogenesis_and_visceral_fat_in_obese_adolescents_ L2 - https://doi.org/10.1038/ijo.2014.11 DB - PRIME DP - Unbound Medicine ER -