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Methylcobalamin: a potential vitamin of pain killer.

Abstract

Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that MeCbl may have potential analgesic effects in experimental and clinical studies. For example, MeCbl alleviated pain behaviors in diabetic neuropathy, low back pain and neuralgia. MeCbl improved nerve conduction, promoted the regeneration of injured nerves, and inhibited ectopic spontaneous discharges of injured primary sensory neurons. This review aims to summarize the analgesic effect and mechanisms of MeCbl at the present.

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  • Authors+Show Affiliations

    ,

    Institute of Neurosciences, The Fourth Military Medical University, Xi'an 710032, China.

    ,

    Institute of Neurosciences, The Fourth Military Medical University, Xi'an 710032, China.

    ,

    Institute of Neurosciences, The Fourth Military Medical University, Xi'an 710032, China.

    Institute of Neurosciences, The Fourth Military Medical University, Xi'an 710032, China.

    Source

    Neural plasticity 2013: 2013 pg 424651

    MeSH

    Analgesics, Non-Narcotic
    Animals
    Humans
    Nerve Regeneration
    Neural Conduction
    Neuralgia
    Pain
    Vitamin B 12
    Vitamins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    24455309

    Citation

    Zhang, Ming, et al. "Methylcobalamin: a Potential Vitamin of Pain Killer." Neural Plasticity, vol. 2013, 2013, p. 424651.
    Zhang M, Han W, Hu S, et al. Methylcobalamin: a potential vitamin of pain killer. Neural Plast. 2013;2013:424651.
    Zhang, M., Han, W., Hu, S., & Xu, H. (2013). Methylcobalamin: a potential vitamin of pain killer. Neural Plasticity, 2013, p. 424651. doi:10.1155/2013/424651.
    Zhang M, et al. Methylcobalamin: a Potential Vitamin of Pain Killer. Neural Plast. 2013;2013:424651. PubMed PMID: 24455309.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Methylcobalamin: a potential vitamin of pain killer. AU - Zhang,Ming, AU - Han,Wenjuan, AU - Hu,Sanjue, AU - Xu,Hui, Y1 - 2013/12/26/ PY - 2013/09/19/received PY - 2013/11/06/revised PY - 2013/11/12/accepted PY - 2014/1/24/entrez PY - 2014/1/24/pubmed PY - 2014/7/23/medline SP - 424651 EP - 424651 JF - Neural plasticity JO - Neural Plast. VL - 2013 N2 - Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that MeCbl may have potential analgesic effects in experimental and clinical studies. For example, MeCbl alleviated pain behaviors in diabetic neuropathy, low back pain and neuralgia. MeCbl improved nerve conduction, promoted the regeneration of injured nerves, and inhibited ectopic spontaneous discharges of injured primary sensory neurons. This review aims to summarize the analgesic effect and mechanisms of MeCbl at the present. SN - 1687-5443 UR - https://www.unboundmedicine.com/medline/citation/24455309/full_citation L2 - https://dx.doi.org/10.1155/2013/424651 DB - PRIME DP - Unbound Medicine ER -