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WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women.
J Appl Physiol (1985). 2014 Mar 15; 116(6):654-67.JA

Abstract

The objectives of this study were to evaluate the efficacy of two separate countermeasures, exercise and protein supplementation, to prevent muscle strength and lean tissue mass losses during 60 days of bed rest (BR) in women and whether countermeasure efficacy was influenced by pre-BR muscular fitness (strength, endurance, tissue mass). Twenty-four women were assigned to an exercise (EX, n = 8), a no-exercise control (CON, n = 8), or a no-exercise protein supplementation group (PROT, n = 8). EX performed supine treadmill exercise within lower body negative pressure 3-4 days/wk and maximal concentric and eccentric supine leg- and calf-press exercises 2-4 days/wk. PROT consumed a diet with elevated protein content compared with CON and EX (1.6 vs. 1.0 g·kg(-1)·day(-1)). Knee and calf isokinetic strength and endurance, isotonic leg-press strength, and leg lean mass were measured before and after BR. Post-BR knee extensor strength and endurance, ankle strength, and leg lean mass were significantly greater and leg-press strength tended to be higher in EX than in CON and PROT. Post-BR measures in PROT were not different than those in CON. Exercise countermeasure efficacy was less, and strength, endurance, and leg lean mass losses in CON and PROT were greater, in subjects who were more fit pre-BR. An exercise protocol combining resistive and aerobic exercise training protects against losses in strength, endurance, and leg lean mass in women during BR, while a nutritional countermeasure without exercise was not effective. Exercise countermeasures may require individualization to protect higher levels of strength and endurance.

Authors+Show Affiliations

Wyle Science, Technology, and Engineering Group, Houston, Texas;No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24458754

Citation

Lee, Stuart M C., et al. "WISE-2005: Countermeasures to Prevent Muscle Deconditioning During Bed Rest in Women." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 116, no. 6, 2014, pp. 654-67.
Lee SM, Schneider SM, Feiveson AH, et al. WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women. J Appl Physiol (1985). 2014;116(6):654-67.
Lee, S. M., Schneider, S. M., Feiveson, A. H., Macias, B. R., Smith, S. M., Watenpaugh, D. E., & Hargens, A. R. (2014). WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women. Journal of Applied Physiology (Bethesda, Md. : 1985), 116(6), 654-67. https://doi.org/10.1152/japplphysiol.00590.2013
Lee SM, et al. WISE-2005: Countermeasures to Prevent Muscle Deconditioning During Bed Rest in Women. J Appl Physiol (1985). 2014 Mar 15;116(6):654-67. PubMed PMID: 24458754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - WISE-2005: Countermeasures to prevent muscle deconditioning during bed rest in women. AU - Lee,Stuart M C, AU - Schneider,Suzanne M, AU - Feiveson,Alan H, AU - Macias,Brandon R, AU - Smith,Scott M, AU - Watenpaugh,Donald E, AU - Hargens,Alan R, Y1 - 2014/01/23/ PY - 2014/1/25/entrez PY - 2014/1/25/pubmed PY - 2014/11/13/medline KW - flywheel exercise KW - muscle endurance KW - muscle strength KW - nutrition KW - spaceflight KW - treadmill exercise within LBNP SP - 654 EP - 67 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 116 IS - 6 N2 - The objectives of this study were to evaluate the efficacy of two separate countermeasures, exercise and protein supplementation, to prevent muscle strength and lean tissue mass losses during 60 days of bed rest (BR) in women and whether countermeasure efficacy was influenced by pre-BR muscular fitness (strength, endurance, tissue mass). Twenty-four women were assigned to an exercise (EX, n = 8), a no-exercise control (CON, n = 8), or a no-exercise protein supplementation group (PROT, n = 8). EX performed supine treadmill exercise within lower body negative pressure 3-4 days/wk and maximal concentric and eccentric supine leg- and calf-press exercises 2-4 days/wk. PROT consumed a diet with elevated protein content compared with CON and EX (1.6 vs. 1.0 g·kg(-1)·day(-1)). Knee and calf isokinetic strength and endurance, isotonic leg-press strength, and leg lean mass were measured before and after BR. Post-BR knee extensor strength and endurance, ankle strength, and leg lean mass were significantly greater and leg-press strength tended to be higher in EX than in CON and PROT. Post-BR measures in PROT were not different than those in CON. Exercise countermeasure efficacy was less, and strength, endurance, and leg lean mass losses in CON and PROT were greater, in subjects who were more fit pre-BR. An exercise protocol combining resistive and aerobic exercise training protects against losses in strength, endurance, and leg lean mass in women during BR, while a nutritional countermeasure without exercise was not effective. Exercise countermeasures may require individualization to protect higher levels of strength and endurance. SN - 1522-1601 UR - https://www.unboundmedicine.com/medline/citation/24458754/WISE_2005:_Countermeasures_to_prevent_muscle_deconditioning_during_bed_rest_in_women_ L2 - https://journals.physiology.org/doi/10.1152/japplphysiol.00590.2013?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -