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High resolution structural changes of Schwann cell and endothelial cells in peripheral nerves across leprosy spectrum.
Ultrastruct Pathol. 2014 Apr; 38(2):86-92.UP

Abstract

A systematic ultrastructure of peripheral nerves across the spectrum of leprosy was studied with an aim to better understanding the pathogenesis of nerve involvement in leprosy using light and electron microscope. The pathogenesis of nerve destruction varies in leprosy considerably along the spectrum. The study has begun to shed new light on some aspects of the infection of Mycobacterium leprae (M. lepare) and phenomenon has opened new avenue of research and possible mechanism of pathogenesis in TT/BT/BL/LL leprosy. In tuberculoid type (TT) and borderline tuberculoid (BT) leprosy, the degenerative changes of Schwann cells (SCs) and presence of perineural and perivascular cuffing by mononuclear cells. The endoneurial blood vessel (EBV) showed thickening of basement membrane with hypertrophy of EC leading to narrowing or complete occlusion of lumen and causing ischemia. However, borderline lepromatous (BL) and lepromatous leprosy (LL) foamy macrophages and vacuolated SC contain numerous small dense materials, irregular in shape and size was prominent and, considered to be degenerated and fragmented M. Leprae. The dense materials were also found in the cytoplasm of vascular EC. It was revealed that besides SC, the EC of EBV frequently harbor M. leprae in LL. The lumen of the EBV was wide open with enlarged nucleus. In the present study, the ultrastructural characteristics suggest that hypersensitivity mechanisms are possibly responsible for nerve damage in TT/BT leprosy. However, the study indicates that the mechanisms of nerve damage in BL/LL are basically different wherein hypersensitivity appears to play a very limited role.

Authors+Show Affiliations

Department of Electron Microscope, National JALMA Institute for Leprosy & Other Mycobacterial Diseases (ICMR) , Taj Ganj, Agra , India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24460757

Citation

Kumar, V, et al. "High Resolution Structural Changes of Schwann Cell and Endothelial Cells in Peripheral Nerves Across Leprosy Spectrum." Ultrastructural Pathology, vol. 38, no. 2, 2014, pp. 86-92.
Kumar V, Sachan T, Natrajan M, et al. High resolution structural changes of Schwann cell and endothelial cells in peripheral nerves across leprosy spectrum. Ultrastruct Pathol. 2014;38(2):86-92.
Kumar, V., Sachan, T., Natrajan, M., & Sharma, A. (2014). High resolution structural changes of Schwann cell and endothelial cells in peripheral nerves across leprosy spectrum. Ultrastructural Pathology, 38(2), 86-92. https://doi.org/10.3109/01913123.2013.870273
Kumar V, et al. High Resolution Structural Changes of Schwann Cell and Endothelial Cells in Peripheral Nerves Across Leprosy Spectrum. Ultrastruct Pathol. 2014;38(2):86-92. PubMed PMID: 24460757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High resolution structural changes of Schwann cell and endothelial cells in peripheral nerves across leprosy spectrum. AU - Kumar,V, AU - Sachan,Tarun, AU - Natrajan,Mohan, AU - Sharma,Ankit, Y1 - 2014/01/24/ PY - 2014/1/28/entrez PY - 2014/1/28/pubmed PY - 2014/11/2/medline SP - 86 EP - 92 JF - Ultrastructural pathology JO - Ultrastruct Pathol VL - 38 IS - 2 N2 - A systematic ultrastructure of peripheral nerves across the spectrum of leprosy was studied with an aim to better understanding the pathogenesis of nerve involvement in leprosy using light and electron microscope. The pathogenesis of nerve destruction varies in leprosy considerably along the spectrum. The study has begun to shed new light on some aspects of the infection of Mycobacterium leprae (M. lepare) and phenomenon has opened new avenue of research and possible mechanism of pathogenesis in TT/BT/BL/LL leprosy. In tuberculoid type (TT) and borderline tuberculoid (BT) leprosy, the degenerative changes of Schwann cells (SCs) and presence of perineural and perivascular cuffing by mononuclear cells. The endoneurial blood vessel (EBV) showed thickening of basement membrane with hypertrophy of EC leading to narrowing or complete occlusion of lumen and causing ischemia. However, borderline lepromatous (BL) and lepromatous leprosy (LL) foamy macrophages and vacuolated SC contain numerous small dense materials, irregular in shape and size was prominent and, considered to be degenerated and fragmented M. Leprae. The dense materials were also found in the cytoplasm of vascular EC. It was revealed that besides SC, the EC of EBV frequently harbor M. leprae in LL. The lumen of the EBV was wide open with enlarged nucleus. In the present study, the ultrastructural characteristics suggest that hypersensitivity mechanisms are possibly responsible for nerve damage in TT/BT leprosy. However, the study indicates that the mechanisms of nerve damage in BL/LL are basically different wherein hypersensitivity appears to play a very limited role. SN - 1521-0758 UR - https://www.unboundmedicine.com/medline/citation/24460757/High_resolution_structural_changes_of_Schwann_cell_and_endothelial_cells_in_peripheral_nerves_across_leprosy_spectrum_ L2 - https://www.tandfonline.com/doi/full/10.3109/01913123.2013.870273 DB - PRIME DP - Unbound Medicine ER -