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Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study.
Clin Microbiol Infect. 2014 May; 20(5):469-74.CM

Abstract

The Saudi Arabian Ministry of Health implemented a pro-active surveillance programme for Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV). We report MERS-CoV data from 5065 Kingdom of Saudi Arabia individuals who were screened for MERS-CoV over a 12-month period. From 1 October 2012 to 30 September 2013, demographic and clinical data were prospectively collected from all laboratory forms received at the Saudi Arabian Virology reference laboratory. Data were analysed by referral type, age, gender, and MERS-CoV real-time PCR test results. Five thousand and 65 individuals were screened for MER-CoV: hospitalized patients with suspected MERS-CoV infection (n = 2908, 57.4%), healthcare worker (HCW) contacts (n = 1695; 33.5%), and family contacts of laboratory-confirmed MERS cases (n = 462; 9.1%). Eleven per cent of persons tested were children (<17 years of age). There were 108 cases (99 adults and nine children) of MERS-CoV infection detected during the 12-month period (108/5065, 2% case detection rate). Of 108 cases, 45 were females (six children and 39 adults) and 63 were males (three children and 60 adults). Of the 99 adults with MERS-CoV infection, 70 were hospitalized patients, 19 were HCW contacts, and ten were family contacts. There were no significant increases in MERS-CoV detection rates over the 12-month period: 2.6% (19/731) in July 2013, 1.7% (19/1100) in August 2013, and 1.69% (21/1238) in September 2013. Male patients had a significantly higher MERS-CoV infection rate (63/2318, 2.7%) than females (45/2747, 1.6%) (p 0.013). MERS-CoV rates remain at low levels, with no significant increase over time. Pro-active surveillance for MERS-CoV in newly diagnosed patients and their contacts will continue.

Authors+Show Affiliations

Global Centre for Mass Gatherings Medicine (GCMGM), Ministry of Health, Riyadh, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24460984

Citation

Memish, Z A., et al. "Screening for Middle East Respiratory Syndrome Coronavirus Infection in Hospital Patients and Their Healthcare Worker and Family Contacts: a Prospective Descriptive Study." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 20, no. 5, 2014, pp. 469-74.
Memish ZA, Al-Tawfiq JA, Makhdoom HQ, et al. Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study. Clin Microbiol Infect. 2014;20(5):469-74.
Memish, Z. A., Al-Tawfiq, J. A., Makhdoom, H. Q., Al-Rabeeah, A. A., Assiri, A., Alhakeem, R. F., AlRabiah, F. A., Al Hajjar, S., Albarrak, A., Flemban, H., Balkhy, H., Barry, M., Alhassan, S., Alsubaie, S., & Zumla, A. (2014). Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(5), 469-74. https://doi.org/10.1111/1469-0691.12562
Memish ZA, et al. Screening for Middle East Respiratory Syndrome Coronavirus Infection in Hospital Patients and Their Healthcare Worker and Family Contacts: a Prospective Descriptive Study. Clin Microbiol Infect. 2014;20(5):469-74. PubMed PMID: 24460984.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study. AU - Memish,Z A, AU - Al-Tawfiq,J A, AU - Makhdoom,H Q, AU - Al-Rabeeah,A A, AU - Assiri,A, AU - Alhakeem,R F, AU - AlRabiah,F A, AU - Al Hajjar,S, AU - Albarrak,A, AU - Flemban,H, AU - Balkhy,H, AU - Barry,M, AU - Alhassan,S, AU - Alsubaie,S, AU - Zumla,A, Y1 - 2014/02/17/ PY - 2013/12/29/received PY - 2014/01/17/accepted PY - 2014/1/28/entrez PY - 2014/1/28/pubmed PY - 2015/2/24/medline KW - Clinical KW - MERS-CoV KW - Middle East KW - SARS KW - coronavirus KW - demographic KW - diagnosis KW - real-time PCR KW - sample type KW - screening KW - viral load SP - 469 EP - 74 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 20 IS - 5 N2 - The Saudi Arabian Ministry of Health implemented a pro-active surveillance programme for Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV). We report MERS-CoV data from 5065 Kingdom of Saudi Arabia individuals who were screened for MERS-CoV over a 12-month period. From 1 October 2012 to 30 September 2013, demographic and clinical data were prospectively collected from all laboratory forms received at the Saudi Arabian Virology reference laboratory. Data were analysed by referral type, age, gender, and MERS-CoV real-time PCR test results. Five thousand and 65 individuals were screened for MER-CoV: hospitalized patients with suspected MERS-CoV infection (n = 2908, 57.4%), healthcare worker (HCW) contacts (n = 1695; 33.5%), and family contacts of laboratory-confirmed MERS cases (n = 462; 9.1%). Eleven per cent of persons tested were children (<17 years of age). There were 108 cases (99 adults and nine children) of MERS-CoV infection detected during the 12-month period (108/5065, 2% case detection rate). Of 108 cases, 45 were females (six children and 39 adults) and 63 were males (three children and 60 adults). Of the 99 adults with MERS-CoV infection, 70 were hospitalized patients, 19 were HCW contacts, and ten were family contacts. There were no significant increases in MERS-CoV detection rates over the 12-month period: 2.6% (19/731) in July 2013, 1.7% (19/1100) in August 2013, and 1.69% (21/1238) in September 2013. Male patients had a significantly higher MERS-CoV infection rate (63/2318, 2.7%) than females (45/2747, 1.6%) (p 0.013). MERS-CoV rates remain at low levels, with no significant increase over time. Pro-active surveillance for MERS-CoV in newly diagnosed patients and their contacts will continue. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/24460984/Screening_for_Middle_East_respiratory_syndrome_coronavirus_infection_in_hospital_patients_and_their_healthcare_worker_and_family_contacts:_a_prospective_descriptive_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(14)60086-0 DB - PRIME DP - Unbound Medicine ER -