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Review of nutrient actions on age-related macular degeneration.
Nutr Res 2014; 34(2):95-105NR

Abstract

The actions of nutrients and related compounds on age-related macular degeneration (AMD) are explained in this review. The findings from 80 studies published since 2003 on the association between diet and supplements in AMD were reviewed. Antioxidants and other nutrients with an effect on AMD susceptibility include carotenoids (lutein and zeaxanthin, β-carotene), vitamins (vitamin A, E, C, D, B), mineral supplements (zinc, copper, selenium), dietary fatty acids [monounsaturated fatty acids, polyunsaturated fatty acids (PUFA both omega-3 PUFA and omega-6 PUFA), saturated fatty acids and cholesterol], and dietary carbohydrates. The literature revealed that many of these antioxidants and nutrients exert a protective role by functioning synergistically. Specifically, the use of dietary supplements with targeted actions can provide minimal benefits on the onset or progression of AMD; however, this does not appear to be particularly beneficial in healthy people. Furthermore, some supplements or nutrients have demonstrated discordant effects on AMD in some studies. Since intake of dietary supplements, as well as exposure to damaging environmental factors, is largely dependent on population habits (including dietary practices) and geographical localization, an overall healthy diet appears to be the best strategy in reducing the risk of developing AMD. As of now, the precise mechanism of action of certain nutrients in AMD prevention remains unclear. Thus, future studies are required to examine the effects that nutrients have on AMD and to determine which factors are most strongly correlated with reducing the risk of AMD or preventing its progression.

Authors+Show Affiliations

Department of Biomedicine and Prevention, School of Medicine, University of Rome "Tor Vergata", Rome, Italy.UOSD Patologia retinica Fondazione PTV "Policlinico Tor Vergata", Rome, Italy.UOSD Patologia retinica Fondazione PTV "Policlinico Tor Vergata", Rome, Italy.Department of Biomedicine and Prevention, School of Medicine, University of Rome "Tor Vergata", Rome, Italy.Department of Biomedicine and Prevention, School of Medicine, University of Rome "Tor Vergata", Rome, Italy; S. Pietro Fatebenefratelli Hospital, Rome, Italy.Department of Biomedicine and Prevention, School of Medicine, University of Rome "Tor Vergata", Rome, Italy; Laboratorio di Genetica Molecolare UILDM, Fondazione Santa Lucia, Rome, Italy. Electronic address: emiliano.giardina@uniroma2.it.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24461310

Citation

Zampatti, Stefania, et al. "Review of Nutrient Actions On Age-related Macular Degeneration." Nutrition Research (New York, N.Y.), vol. 34, no. 2, 2014, pp. 95-105.
Zampatti S, Ricci F, Cusumano A, et al. Review of nutrient actions on age-related macular degeneration. Nutr Res. 2014;34(2):95-105.
Zampatti, S., Ricci, F., Cusumano, A., Marsella, L. T., Novelli, G., & Giardina, E. (2014). Review of nutrient actions on age-related macular degeneration. Nutrition Research (New York, N.Y.), 34(2), pp. 95-105. doi:10.1016/j.nutres.2013.10.011.
Zampatti S, et al. Review of Nutrient Actions On Age-related Macular Degeneration. Nutr Res. 2014;34(2):95-105. PubMed PMID: 24461310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Review of nutrient actions on age-related macular degeneration. AU - Zampatti,Stefania, AU - Ricci,Federico, AU - Cusumano,Andrea, AU - Marsella,Luigi Tonino, AU - Novelli,Giuseppe, AU - Giardina,Emiliano, Y1 - 2013/11/04/ PY - 2013/05/21/received PY - 2013/10/11/revised PY - 2013/10/28/accepted PY - 2014/1/28/entrez PY - 2014/1/28/pubmed PY - 2014/9/12/medline KW - AMD KW - Age-related macular degeneration KW - Antioxidants KW - DHA KW - DRI KW - Disease susceptibility KW - EPA KW - Food habits KW - HDL KW - LDL KW - MPOD KW - MUFA KW - Nutrients KW - Nutrition surveys KW - OR KW - ROS KW - RPE KW - RR KW - SFA KW - age-related macular degeneration KW - dietary reference intake KW - docosahexaenoic acid KW - eicosapentaenoic acid KW - high-density lipoproteins KW - low-density lipoproteins KW - macular pigment optical density KW - monounsaturated fatty acid KW - odds ratio KW - reactive oxygen species KW - relative risk KW - retinal pigmented epithelium KW - saturated fatty acid SP - 95 EP - 105 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 2 N2 - The actions of nutrients and related compounds on age-related macular degeneration (AMD) are explained in this review. The findings from 80 studies published since 2003 on the association between diet and supplements in AMD were reviewed. Antioxidants and other nutrients with an effect on AMD susceptibility include carotenoids (lutein and zeaxanthin, β-carotene), vitamins (vitamin A, E, C, D, B), mineral supplements (zinc, copper, selenium), dietary fatty acids [monounsaturated fatty acids, polyunsaturated fatty acids (PUFA both omega-3 PUFA and omega-6 PUFA), saturated fatty acids and cholesterol], and dietary carbohydrates. The literature revealed that many of these antioxidants and nutrients exert a protective role by functioning synergistically. Specifically, the use of dietary supplements with targeted actions can provide minimal benefits on the onset or progression of AMD; however, this does not appear to be particularly beneficial in healthy people. Furthermore, some supplements or nutrients have demonstrated discordant effects on AMD in some studies. Since intake of dietary supplements, as well as exposure to damaging environmental factors, is largely dependent on population habits (including dietary practices) and geographical localization, an overall healthy diet appears to be the best strategy in reducing the risk of developing AMD. As of now, the precise mechanism of action of certain nutrients in AMD prevention remains unclear. Thus, future studies are required to examine the effects that nutrients have on AMD and to determine which factors are most strongly correlated with reducing the risk of AMD or preventing its progression. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24461310/Review_of_nutrient_actions_on_age_related_macular_degeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00267-4 DB - PRIME DP - Unbound Medicine ER -