Tags

Type your tag names separated by a space and hit enter

Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels.
Nutr Res. 2014 Feb; 34(2):126-33.NR

Abstract

The aim of the study was to explore the effects of 12 weeks daily krill oil supplementation on fasting serum triglyceride (TG) and lipoprotein particle levels in subjects whose habitual fish intake is low and who have borderline high or high fasting serum TG levels (150-499 mg/dL). We hypothesized that Krill oil lowers serum TG levels in subjects with borderline high or high fasting TG levels. To test our hypothesis 300 male and female subjects were included in a double-blind, randomized, multi-center, placebo-controlled study with five treatment groups: placebo (olive oil) or 0.5, 1, 2, or 4 g/day of krill oil. Serum lipids were measured after an overnight fast at baseline, 6 and 12 weeks. Due to a high intra-individual variability in TG levels, data from all subjects in the four krill oil groups were pooled to increase statistical power, and a general time- and dose-independent one-way analysis of variance was performed to assess efficacy. Relative to subjects in the placebo group, those administered krill oil had a statistically significant calculated reduction in serum TG levels of 10.2%. Moreover, LDL-C levels were not increased in the krill oil groups relative to the placebo group. The outcome of the pooled analysis suggests that krill oil is effective in reducing a cardiovascular risk factor. However, owing to the individual fluctuations of TG concentrations measured, a study with more individual measurements per treatment group is needed to increase the confidence of these findings.

Authors+Show Affiliations

Aker BioMarine ASA, Fjordalléen 16, 0115 Oslo, Norway. Electronic address: kjetil.berge@akerbiomarine.com.Intertek Cantox, Mississauga, Ontario, Canada L5N 2X7.Aker BioMarine ASA, Fjordalléen 16, 0115 Oslo, Norway.Aker BioMarine ASA, Fjordalléen 16, 0115 Oslo, Norway.Aker BioMarine ASA, Fjordalléen 16, 0115 Oslo, Norway.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24461313

Citation

Berge, Kjetil, et al. "Krill Oil Supplementation Lowers Serum Triglycerides Without Increasing Low-density Lipoprotein Cholesterol in Adults With Borderline High or High Triglyceride Levels." Nutrition Research (New York, N.Y.), vol. 34, no. 2, 2014, pp. 126-33.
Berge K, Musa-Veloso K, Harwood M, et al. Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutr Res. 2014;34(2):126-33.
Berge, K., Musa-Veloso, K., Harwood, M., Hoem, N., & Burri, L. (2014). Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. Nutrition Research (New York, N.Y.), 34(2), 126-33. https://doi.org/10.1016/j.nutres.2013.12.003
Berge K, et al. Krill Oil Supplementation Lowers Serum Triglycerides Without Increasing Low-density Lipoprotein Cholesterol in Adults With Borderline High or High Triglyceride Levels. Nutr Res. 2014;34(2):126-33. PubMed PMID: 24461313.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Krill oil supplementation lowers serum triglycerides without increasing low-density lipoprotein cholesterol in adults with borderline high or high triglyceride levels. AU - Berge,Kjetil, AU - Musa-Veloso,Kathy, AU - Harwood,Melody, AU - Hoem,Nils, AU - Burri,Lena, Y1 - 2013/12/18/ PY - 2013/08/14/received PY - 2013/12/11/revised PY - 2013/12/12/accepted PY - 2014/1/28/entrez PY - 2014/1/28/pubmed PY - 2014/9/12/medline KW - ANOVA KW - BMI KW - CVD KW - Cardiovascular disease risk KW - DHA KW - Docosahexaenoic acid KW - EFSA KW - EPA KW - Eicosapentaenoic acid KW - European Food Safety Authority KW - HDL-C KW - Krill oil KW - LDL-C KW - Low-density lipoprotein cholesterol KW - NDA Panel KW - NHPD KW - Natural Health Products Directorate KW - Omega-3 index KW - PL KW - Panel on Dietetic Products, Nutrition and Allergies KW - Phospholipids KW - SD KW - TG KW - Triglycerides KW - U.S KW - United States KW - analysis of variance KW - body mass index KW - cardiovascular disease KW - clinical trial KW - docosahexaenoic acid KW - eicosapentaenoic acid KW - high-density lipoprotein cholesterol KW - low-density lipoprotein cholesterol KW - n-3 LCPUFAs KW - omega-3 long-chain polyunsaturated fatty acids KW - phospholipid KW - standard deviation KW - triglyceride SP - 126 EP - 33 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 34 IS - 2 N2 - The aim of the study was to explore the effects of 12 weeks daily krill oil supplementation on fasting serum triglyceride (TG) and lipoprotein particle levels in subjects whose habitual fish intake is low and who have borderline high or high fasting serum TG levels (150-499 mg/dL). We hypothesized that Krill oil lowers serum TG levels in subjects with borderline high or high fasting TG levels. To test our hypothesis 300 male and female subjects were included in a double-blind, randomized, multi-center, placebo-controlled study with five treatment groups: placebo (olive oil) or 0.5, 1, 2, or 4 g/day of krill oil. Serum lipids were measured after an overnight fast at baseline, 6 and 12 weeks. Due to a high intra-individual variability in TG levels, data from all subjects in the four krill oil groups were pooled to increase statistical power, and a general time- and dose-independent one-way analysis of variance was performed to assess efficacy. Relative to subjects in the placebo group, those administered krill oil had a statistically significant calculated reduction in serum TG levels of 10.2%. Moreover, LDL-C levels were not increased in the krill oil groups relative to the placebo group. The outcome of the pooled analysis suggests that krill oil is effective in reducing a cardiovascular risk factor. However, owing to the individual fluctuations of TG concentrations measured, a study with more individual measurements per treatment group is needed to increase the confidence of these findings. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/24461313/Krill_oil_supplementation_lowers_serum_triglycerides_without_increasing_low_density_lipoprotein_cholesterol_in_adults_with_borderline_high_or_high_triglyceride_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(13)00283-2 DB - PRIME DP - Unbound Medicine ER -