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The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.

Abstract

OBJECTIVE

Brain-derived neurotropic factor (BDNF) is widely distributed in the peripheral and central nervous systems. BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. To elucidate the role of BDNF, we compared the plasma BDNF levels and the BDNF Val66Met gene variants effect in several mental disorders.

METHOD

We enrolled 644 participants: 177 patients with bipolar I disorder (BP-I), 190 with bipolar II disorder (BP-II), 151 with schizophrenia, and 126 healthy controls. Their plasma BDNF levels and BDNF Val66Met single nucleotide polymorphisms (SNP) were checked before pharmacological treatment.

RESULTS

Plasma levels of BDNF were significantly lower in patients with schizophrenia than in healthy controls and patients with bipolar disorder (F = 37.667, p<0.001); the distribution of the BDNF Val66Met SNP was not different between groups (χ(2) = 5.289, p = 0.507). Nor were plasma BDNF levels significantly different between Met/Met, Met/Val, and Val/Val carriers in each group, which indicated that the BDNF Val66Met SNP did not influence plasma BDNF levels in our participants. Plasma BDNF levels were, however, significantly negatively correlated with depression scores in patients with bipolar disorder and with negative symptoms in patients with schizophrenia.

CONCLUSION

We conclude that plasma BDNF profiles in different mental disorders are not affected by BDNF Val66Met gene variants, but by the process and progression of the illness itself.

Authors+Show Affiliations

Department of Neurology, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Psychiatry, National Cheng Kung University, Taiwan. Electronic address: shioulan@mail.ncku.edu.tw.Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung University, Taiwan.Department of Psychiatry, National Cheng Kung University, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan.Department of Psychiatry, National Cheng Kung University, Taiwan; Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, USA.Department of Psychiatry, National Cheng Kung University, Taiwan; Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, USA.Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan.Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung University, Taiwan.Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung University, Taiwan.Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung University, Taiwan.Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC, USA.Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng Kung University Hospital, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Taiwan; Addiction Research Center, National Cheng Kung University, Taiwan; Institute of Behavior Medicine, National Cheng Kung University, Taiwan; Center for Neuropsychiatric Research, National Health Research Institutes, Taiwan. Electronic address: rblu@mail.ncku.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24468644

Citation

Chen, Shiou-Lan, et al. "The BDNF Val66Met Polymorphism and Plasma Brain-derived Neurotrophic Factor Levels in Han Chinese Patients With Bipolar Disorder and Schizophrenia." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 51, 2014, pp. 99-104.
Chen SL, Lee SY, Chang YH, et al. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2014;51:99-104.
Chen, S. L., Lee, S. Y., Chang, Y. H., Chen, S. H., Chu, C. H., Wang, T. Y., ... Lu, R. B. (2014). The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Progress in Neuro-psychopharmacology & Biological Psychiatry, 51, pp. 99-104. doi:10.1016/j.pnpbp.2014.01.012.
Chen SL, et al. The BDNF Val66Met Polymorphism and Plasma Brain-derived Neurotrophic Factor Levels in Han Chinese Patients With Bipolar Disorder and Schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:99-104. PubMed PMID: 24468644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. AU - Chen,Shiou-Lan, AU - Lee,Sheng-Yu, AU - Chang,Yun-Hsuan, AU - Chen,Shih-Heng, AU - Chu,Chun-Hsien, AU - Wang,Tzu-Yun, AU - Chen,Po-See, AU - Lee,I-Hui, AU - Yang,Yen-Kuang, AU - Hong,Jau-Shyong, AU - Lu,Ru-Band, Y1 - 2014/01/25/ PY - 2013/09/03/received PY - 2014/01/07/revised PY - 2014/01/19/accepted PY - 2014/1/29/entrez PY - 2014/1/29/pubmed PY - 2014/12/15/medline KW - BDNF Val66Met gene KW - Bipolar disorders KW - Plasma BDNF KW - Schizophrenia SP - 99 EP - 104 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 51 N2 - OBJECTIVE: Brain-derived neurotropic factor (BDNF) is widely distributed in the peripheral and central nervous systems. BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of several mental illnesses. To elucidate the role of BDNF, we compared the plasma BDNF levels and the BDNF Val66Met gene variants effect in several mental disorders. METHOD: We enrolled 644 participants: 177 patients with bipolar I disorder (BP-I), 190 with bipolar II disorder (BP-II), 151 with schizophrenia, and 126 healthy controls. Their plasma BDNF levels and BDNF Val66Met single nucleotide polymorphisms (SNP) were checked before pharmacological treatment. RESULTS: Plasma levels of BDNF were significantly lower in patients with schizophrenia than in healthy controls and patients with bipolar disorder (F = 37.667, p<0.001); the distribution of the BDNF Val66Met SNP was not different between groups (χ(2) = 5.289, p = 0.507). Nor were plasma BDNF levels significantly different between Met/Met, Met/Val, and Val/Val carriers in each group, which indicated that the BDNF Val66Met SNP did not influence plasma BDNF levels in our participants. Plasma BDNF levels were, however, significantly negatively correlated with depression scores in patients with bipolar disorder and with negative symptoms in patients with schizophrenia. CONCLUSION: We conclude that plasma BDNF profiles in different mental disorders are not affected by BDNF Val66Met gene variants, but by the process and progression of the illness itself. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/24468644/The_BDNF_Val66Met_polymorphism_and_plasma_brain_derived_neurotrophic_factor_levels_in_Han_Chinese_patients_with_bipolar_disorder_and_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(14)00013-X DB - PRIME DP - Unbound Medicine ER -