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Oxygen transport to tissue modified by entrapment of an allosteric effector of haemoglobin in erythrocytes.

Abstract

Oxygen affinity of haemoglobin is modulated by several parameters such as the allosteric effector 2-3 DPG for most mammalians. Inositol hexaphosphate (I.H.P.) exerts the same effect on haemoglobin. A previously developed new methodology for the entrapment of drugs into erythrocytes has been adapted to I.H.P.; it is based on a reversible osmotic shock. I.H.P. loaded red blood cells have characteristics very similar to those of native cells. The decrease in oxygen affinity is related to the dose of encapsulated I.H.P. In piglets, transfusion of such cells has led to an increase of oxygen extraction from haemoglobin. Normal anesthetized animals regulate their oxygen consumption by reduction of cardiac output.

Authors+Show Affiliations

Centre National de Transfusion Sanguine, Les Ulis, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2446985

Citation

Villereal, M C., et al. "Oxygen Transport to Tissue Modified By Entrapment of an Allosteric Effector of Haemoglobin in Erythrocytes." Folia Haematologica (Leipzig, Germany : 1928), vol. 114, no. 4, 1987, pp. 488-92.
Villereal MC, Ropars C, Hurel C, et al. Oxygen transport to tissue modified by entrapment of an allosteric effector of haemoglobin in erythrocytes. Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(4):488-92.
Villereal, M. C., Ropars, C., Hurel, C., Teisseire, B., Chassaigne, M., Itti, R., Casset, D., & Nicolau, C. (1987). Oxygen transport to tissue modified by entrapment of an allosteric effector of haemoglobin in erythrocytes. Folia Haematologica (Leipzig, Germany : 1928), 114(4), 488-92.
Villereal MC, et al. Oxygen Transport to Tissue Modified By Entrapment of an Allosteric Effector of Haemoglobin in Erythrocytes. Folia Haematol Int Mag Klin Morphol Blutforsch. 1987;114(4):488-92. PubMed PMID: 2446985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxygen transport to tissue modified by entrapment of an allosteric effector of haemoglobin in erythrocytes. AU - Villereal,M C, AU - Ropars,C, AU - Hurel,C, AU - Teisseire,B, AU - Chassaigne,M, AU - Itti,R, AU - Casset,D, AU - Nicolau,C, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 488 EP - 92 JF - Folia haematologica (Leipzig, Germany : 1928) JO - Folia Haematol Int Mag Klin Morphol Blutforsch VL - 114 IS - 4 N2 - Oxygen affinity of haemoglobin is modulated by several parameters such as the allosteric effector 2-3 DPG for most mammalians. Inositol hexaphosphate (I.H.P.) exerts the same effect on haemoglobin. A previously developed new methodology for the entrapment of drugs into erythrocytes has been adapted to I.H.P.; it is based on a reversible osmotic shock. I.H.P. loaded red blood cells have characteristics very similar to those of native cells. The decrease in oxygen affinity is related to the dose of encapsulated I.H.P. In piglets, transfusion of such cells has led to an increase of oxygen extraction from haemoglobin. Normal anesthetized animals regulate their oxygen consumption by reduction of cardiac output. SN - 0323-4347 UR - https://www.unboundmedicine.com/medline/citation/2446985/Oxygen_transport_to_tissue_modified_by_entrapment_of_an_allosteric_effector_of_haemoglobin_in_erythrocytes_ DB - PRIME DP - Unbound Medicine ER -