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Hydrogenative dearomatization of pyridine and an asymmetric aza-Friedel-Crafts alkylation sequence.
Angew Chem Int Ed Engl. 2014 Feb 17; 53(8):2194-7.AC

Abstract

Highly efficient synthesis of enantiomerically enriched substituted piperidines has been realized via chiral phosphoric acid catalyzed cascade hydrogenative dearomatization of substituted pyridines and aza-Friedel-Crafts reaction in good to excellent yields and enantioselectivity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wang SG
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn/
You SL
No affiliation info available

MeSH

AlkylationAza CompoundsCatalysisHydrogenationMetalsOxidation-ReductionPhosphoric AcidsPyridinesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24470000

Citation

Wang, Shuo-Guo, and Shu-Li You. "Hydrogenative Dearomatization of Pyridine and an Asymmetric aza-Friedel-Crafts Alkylation Sequence." Angewandte Chemie (International Ed. in English), vol. 53, no. 8, 2014, pp. 2194-7.
Wang SG, You SL. Hydrogenative dearomatization of pyridine and an asymmetric aza-Friedel-Crafts alkylation sequence. Angew Chem Int Ed Engl. 2014;53(8):2194-7.
Wang, S. G., & You, S. L. (2014). Hydrogenative dearomatization of pyridine and an asymmetric aza-Friedel-Crafts alkylation sequence. Angewandte Chemie (International Ed. in English), 53(8), 2194-7. https://doi.org/10.1002/anie.201309876
Wang SG, You SL. Hydrogenative Dearomatization of Pyridine and an Asymmetric aza-Friedel-Crafts Alkylation Sequence. Angew Chem Int Ed Engl. 2014 Feb 17;53(8):2194-7. PubMed PMID: 24470000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogenative dearomatization of pyridine and an asymmetric aza-Friedel-Crafts alkylation sequence. AU - Wang,Shuo-Guo, AU - You,Shu-Li, Y1 - 2014/01/27/ PY - 2013/11/13/received PY - 2014/1/29/entrez PY - 2014/1/29/pubmed PY - 2014/12/15/medline KW - asymmetric catalysis KW - heterocycles KW - organocatalysis KW - reduction KW - synthetic methods SP - 2194 EP - 7 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 53 IS - 8 N2 - Highly efficient synthesis of enantiomerically enriched substituted piperidines has been realized via chiral phosphoric acid catalyzed cascade hydrogenative dearomatization of substituted pyridines and aza-Friedel-Crafts reaction in good to excellent yields and enantioselectivity. SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/24470000/Hydrogenative_dearomatization_of_pyridine_and_an_asymmetric_aza_Friedel_Crafts_alkylation_sequence_ DB - PRIME DP - Unbound Medicine ER -