Tags

Type your tag names separated by a space and hit enter

Severity of lower urinary tract symptoms reflects different composition of bladder storage dysfunction and bladder outlet obstruction in men with symptomatic benign prostatic hyperplasia.
Int J Clin Pract. 2014 Jun; 68(6):743-8.IJ

Abstract

AIMS

Differentiation of different lower urinary tract dysfunctions (LUTD) is essential for selecting the optimal first-line medical treatment of lower urinary tract symptoms (LUTS). This study analysed the association of the severity of LUTS with LUTD and therapeutic results based on the International Prostate Symptom Score (IPSS) voiding to storage (V/S) ratio.

MATERIALS AND METHODS

Lower urinary tract symptoms were evaluated in 849 men using the IPSS questionnaire and the IPSS-V/S ratio. The prostate measures, urinary flow measures, and C-reactive protein (CRP) were investigated at baseline and 1 month after treatment. Therapeutic results were assessed by changes in the quality of life index (QoL-I). The associations of the severity of LUTS with LUTD and therapeutic results were analysed.

RESULTS

Mild (IPSS ≤ 7), moderate (8 ≤ IPSS ≤ 19) and severe LUTS (IPSS ≥ 20) were noted in 215, 461 and 173 men. IPSS-V/S ≤ 1 was noted in 81.4% of patients with mild LUTS, while IPSS-V/S > 1 was noted in 71.1% of patients with severe LUTS. After treatment with alpha-blockers in patients with IPSS-V/S > 1 and antimuscarinic agents in patients with IPSS-V/S ≤ 1 for 1 month, 84.0% and 88.8% of patients with mild LUTS had effective therapeutic results, respectively. In contrast, the therapeutic results were less effective in patients with moderate (64.9% and 63.8%, respectively) or severe LUTS (50% and 33.3%, respectively).

CONCLUSION

Patients with benign prostatic hyperplasia (BPH) and mild LUTS have more bladder storage dysfunction, whereas patients with BPH and severe LUTS had higher grade of bladder outlet disorders in associated with storage symptoms. Treatment based on the IPSS-V/S ratio results in good therapeutic results in men with mild and moderate LUTS, but not in men with severe LUTS.

Authors+Show Affiliations

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24471413

Citation

Jhang, J-F, et al. "Severity of Lower Urinary Tract Symptoms Reflects Different Composition of Bladder Storage Dysfunction and Bladder Outlet Obstruction in Men With Symptomatic Benign Prostatic Hyperplasia." International Journal of Clinical Practice, vol. 68, no. 6, 2014, pp. 743-8.
Jhang JF, Liao CH, Kuo HC. Severity of lower urinary tract symptoms reflects different composition of bladder storage dysfunction and bladder outlet obstruction in men with symptomatic benign prostatic hyperplasia. Int J Clin Pract. 2014;68(6):743-8.
Jhang, J. F., Liao, C. H., & Kuo, H. C. (2014). Severity of lower urinary tract symptoms reflects different composition of bladder storage dysfunction and bladder outlet obstruction in men with symptomatic benign prostatic hyperplasia. International Journal of Clinical Practice, 68(6), 743-8. https://doi.org/10.1111/ijcp.12364
Jhang JF, Liao CH, Kuo HC. Severity of Lower Urinary Tract Symptoms Reflects Different Composition of Bladder Storage Dysfunction and Bladder Outlet Obstruction in Men With Symptomatic Benign Prostatic Hyperplasia. Int J Clin Pract. 2014;68(6):743-8. PubMed PMID: 24471413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severity of lower urinary tract symptoms reflects different composition of bladder storage dysfunction and bladder outlet obstruction in men with symptomatic benign prostatic hyperplasia. AU - Jhang,J-F, AU - Liao,C-H, AU - Kuo,H-C, Y1 - 2014/01/29/ PY - 2014/1/30/entrez PY - 2014/1/30/pubmed PY - 2016/5/18/medline SP - 743 EP - 8 JF - International journal of clinical practice JO - Int J Clin Pract VL - 68 IS - 6 N2 - AIMS: Differentiation of different lower urinary tract dysfunctions (LUTD) is essential for selecting the optimal first-line medical treatment of lower urinary tract symptoms (LUTS). This study analysed the association of the severity of LUTS with LUTD and therapeutic results based on the International Prostate Symptom Score (IPSS) voiding to storage (V/S) ratio. MATERIALS AND METHODS: Lower urinary tract symptoms were evaluated in 849 men using the IPSS questionnaire and the IPSS-V/S ratio. The prostate measures, urinary flow measures, and C-reactive protein (CRP) were investigated at baseline and 1 month after treatment. Therapeutic results were assessed by changes in the quality of life index (QoL-I). The associations of the severity of LUTS with LUTD and therapeutic results were analysed. RESULTS: Mild (IPSS ≤ 7), moderate (8 ≤ IPSS ≤ 19) and severe LUTS (IPSS ≥ 20) were noted in 215, 461 and 173 men. IPSS-V/S ≤ 1 was noted in 81.4% of patients with mild LUTS, while IPSS-V/S > 1 was noted in 71.1% of patients with severe LUTS. After treatment with alpha-blockers in patients with IPSS-V/S > 1 and antimuscarinic agents in patients with IPSS-V/S ≤ 1 for 1 month, 84.0% and 88.8% of patients with mild LUTS had effective therapeutic results, respectively. In contrast, the therapeutic results were less effective in patients with moderate (64.9% and 63.8%, respectively) or severe LUTS (50% and 33.3%, respectively). CONCLUSION: Patients with benign prostatic hyperplasia (BPH) and mild LUTS have more bladder storage dysfunction, whereas patients with BPH and severe LUTS had higher grade of bladder outlet disorders in associated with storage symptoms. Treatment based on the IPSS-V/S ratio results in good therapeutic results in men with mild and moderate LUTS, but not in men with severe LUTS. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/24471413/Severity_of_lower_urinary_tract_symptoms_reflects_different_composition_of_bladder_storage_dysfunction_and_bladder_outlet_obstruction_in_men_with_symptomatic_benign_prostatic_hyperplasia_ L2 - https://doi.org/10.1111/ijcp.12364 DB - PRIME DP - Unbound Medicine ER -