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Additional role of serum 25-hydroxyvitamin D3 levels in atherosclerosis in Chinese middle-aged and elderly men.
Clin Exp Pharmacol Physiol 2014; 41(3):174-9CE

Abstract

1. Perturbed serum vitamin D levels have been shown to be associated with increased risk of cardiovascular disease. The aim of the present study was to investigate the association of serum 25-hydroxyvitamin D3 (25(OH)D3) levels and B ultrasonography-detected carotid plaque and carotid intima-media thickness (C-IMT) in Chinese middle-aged and elderly men. 2. In all, 1001 men, aged 45-78 years, were enrolled in the study. Increased C-IMT was defined as any C-IMT value in the highest quartile of the study subjects (≥ 0.75 mm). 3. The study population had a median serum 25(OH)D3 level of 14.51 ng/mL (interquartile range (IQR) 10.84-18.67 ng/mL). Subjects with carotid plaques had lower serum 25(OH)D3 levels than those without (13.80 (IQR 10.82-17.68) vs 14.74 (IQR 10.87-19.08) ng/mL, respectively; P = 0.029), and decreasing serum 25(OH)D3 levels were accompanied by increased C-IMT in both groups (13.24 (IQR 9.91-16.81) vs 14.45 (IQR 11.40-18.51) ng/mL, respectively (P < 0.05) in those with plaque; 13.80 (IQR 9.99-17.09) vs 14.99 (IQR 11.17-19.43) ng/mL, respectively (P < 0.01) in those without plaque). Multivariate logistic regression analysis showed that serum 25(OH)D3 levels were independently associated with carotid plaque (odds ratio (OR) 0.972; 95% confidence interval (CI) 0.946-0.998; P = 0.032). In addition, serum 25(OH)D3 levels were identified as an independent protective factor for increased C-IMT among subjects with plaque (OR 0.900; 95% CI 0.849-0.955; P = 0.001) and those without plaque (OR 0.944; 95% CI 0.908-0.981; P = 0.004). 4. Collectively, these findings suggest that serum 25(OH)D3 levels are inversely associated with atherosclerosis in Chinese middle-aged and elderly men.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Shanghai Clinical Center for Diabetes, Shanghai, China; Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China; Shanghai Diabetes Institute, Shanghai, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24471522

Citation

Hao, Yaping, et al. "Additional Role of Serum 25-hydroxyvitamin D3 Levels in Atherosclerosis in Chinese Middle-aged and Elderly Men." Clinical and Experimental Pharmacology & Physiology, vol. 41, no. 3, 2014, pp. 174-9.
Hao Y, Ma X, Luo Y, et al. Additional role of serum 25-hydroxyvitamin D3 levels in atherosclerosis in Chinese middle-aged and elderly men. Clin Exp Pharmacol Physiol. 2014;41(3):174-9.
Hao, Y., Ma, X., Luo, Y., Ni, J., Dou, J., Zhu, J., ... Jia, W. (2014). Additional role of serum 25-hydroxyvitamin D3 levels in atherosclerosis in Chinese middle-aged and elderly men. Clinical and Experimental Pharmacology & Physiology, 41(3), pp. 174-9. doi:10.1111/1440-1681.12200.
Hao Y, et al. Additional Role of Serum 25-hydroxyvitamin D3 Levels in Atherosclerosis in Chinese Middle-aged and Elderly Men. Clin Exp Pharmacol Physiol. 2014;41(3):174-9. PubMed PMID: 24471522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Additional role of serum 25-hydroxyvitamin D3 levels in atherosclerosis in Chinese middle-aged and elderly men. AU - Hao,Yaping, AU - Ma,Xiaojing, AU - Luo,Yuqi, AU - Ni,Jie, AU - Dou,Jianxin, AU - Zhu,Jiaan, AU - Bao,Yuqian, AU - Jia,Weiping, PY - 2013/11/06/received PY - 2014/01/02/revised PY - 2014/01/15/accepted PY - 2014/1/30/entrez PY - 2014/1/30/pubmed PY - 2014/11/11/medline KW - carotid intima-media thickness KW - carotid plaque KW - vitamin D SP - 174 EP - 9 JF - Clinical and experimental pharmacology & physiology JO - Clin. Exp. Pharmacol. Physiol. VL - 41 IS - 3 N2 - 1. Perturbed serum vitamin D levels have been shown to be associated with increased risk of cardiovascular disease. The aim of the present study was to investigate the association of serum 25-hydroxyvitamin D3 (25(OH)D3) levels and B ultrasonography-detected carotid plaque and carotid intima-media thickness (C-IMT) in Chinese middle-aged and elderly men. 2. In all, 1001 men, aged 45-78 years, were enrolled in the study. Increased C-IMT was defined as any C-IMT value in the highest quartile of the study subjects (≥ 0.75 mm). 3. The study population had a median serum 25(OH)D3 level of 14.51 ng/mL (interquartile range (IQR) 10.84-18.67 ng/mL). Subjects with carotid plaques had lower serum 25(OH)D3 levels than those without (13.80 (IQR 10.82-17.68) vs 14.74 (IQR 10.87-19.08) ng/mL, respectively; P = 0.029), and decreasing serum 25(OH)D3 levels were accompanied by increased C-IMT in both groups (13.24 (IQR 9.91-16.81) vs 14.45 (IQR 11.40-18.51) ng/mL, respectively (P < 0.05) in those with plaque; 13.80 (IQR 9.99-17.09) vs 14.99 (IQR 11.17-19.43) ng/mL, respectively (P < 0.01) in those without plaque). Multivariate logistic regression analysis showed that serum 25(OH)D3 levels were independently associated with carotid plaque (odds ratio (OR) 0.972; 95% confidence interval (CI) 0.946-0.998; P = 0.032). In addition, serum 25(OH)D3 levels were identified as an independent protective factor for increased C-IMT among subjects with plaque (OR 0.900; 95% CI 0.849-0.955; P = 0.001) and those without plaque (OR 0.944; 95% CI 0.908-0.981; P = 0.004). 4. Collectively, these findings suggest that serum 25(OH)D3 levels are inversely associated with atherosclerosis in Chinese middle-aged and elderly men. SN - 1440-1681 UR - https://www.unboundmedicine.com/medline/citation/24471522/Additional_role_of_serum_25_hydroxyvitamin_D3_levels_in_atherosclerosis_in_Chinese_middle_aged_and_elderly_men_ L2 - https://doi.org/10.1111/1440-1681.12200 DB - PRIME DP - Unbound Medicine ER -