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Hockey Concussion Education Project, Part 3. White matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study.
J Neurosurg 2014; 120(4):882-90JN

Abstract

OBJECT

The aim of this study was to examine the brain's white matter microstructure by using MR diffusion tensor imaging (DTI) in ice hockey players with a history of clinically symptomatic concussion compared with players without a history of concussion.

METHODS

Sixteen players with a history of concussion (concussed group; mean age 21.7 ± 1.5 years; 6 female) and 18 players without a history of concussion (nonconcussed group; mean age 21.3 ± 1.8 years, 10 female) underwent 3-T DTI at the end of the 2011-2012 Canadian Interuniversity Sports ice hockey season. Tract-based spatial statistics (TBSS) was used to test for group differences in fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and the measure "trace," or mean diffusivity. Cognitive evaluation was performed using the Immediate Postconcussion Assessment and Cognitive Test (ImPACT) and the Sport Concussion Assessment Tool-2 (SCAT2).

RESULTS

TBSS revealed a significant increase in FA and AD, and a significant decrease in RD and trace in several brain regions in the concussed group, compared with the nonconcussed group (p < 0.05). The regions with increased FA and decreased RD and trace included the right posterior limb of the internal capsule, the right corona radiata, and the right temporal lobe. Increased AD was observed in a small area in the left corona radiata. The DTI measures correlated with neither the ImPACT nor the SCAT2 scores.

CONCLUSIONS

The results of the current study indicate that a history of concussion may result in alterations of the brain's white matter microstructure in ice hockey players. Increased FA based on decreased RD may reflect neuroinflammatory or neuroplastic processes of the brain responding to brain trauma. Future studies are needed that include a longitudinal analysis of the brain's structure and function following a concussion to elucidate further the complex time course of DTI changes and their clinical meaning.

Authors+Show Affiliations

Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts;No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

24471841

Citation

Sasaki, Takeshi, et al. "Hockey Concussion Education Project, Part 3. White Matter Microstructure in Ice Hockey Players With a History of Concussion: a Diffusion Tensor Imaging Study." Journal of Neurosurgery, vol. 120, no. 4, 2014, pp. 882-90.
Sasaki T, Pasternak O, Mayinger M, et al. Hockey Concussion Education Project, Part 3. White matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study. J Neurosurg. 2014;120(4):882-90.
Sasaki, T., Pasternak, O., Mayinger, M., Muehlmann, M., Savadjiev, P., Bouix, S., ... Koerte, I. K. (2014). Hockey Concussion Education Project, Part 3. White matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study. Journal of Neurosurgery, 120(4), pp. 882-90. doi:10.3171/2013.12.JNS132092.
Sasaki T, et al. Hockey Concussion Education Project, Part 3. White Matter Microstructure in Ice Hockey Players With a History of Concussion: a Diffusion Tensor Imaging Study. J Neurosurg. 2014;120(4):882-90. PubMed PMID: 24471841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hockey Concussion Education Project, Part 3. White matter microstructure in ice hockey players with a history of concussion: a diffusion tensor imaging study. AU - Sasaki,Takeshi, AU - Pasternak,Ofer, AU - Mayinger,Michael, AU - Muehlmann,Marc, AU - Savadjiev,Peter, AU - Bouix,Sylvain, AU - Kubicki,Marek, AU - Fredman,Eli, AU - Dahlben,Brian, AU - Helmer,Karl G, AU - Johnson,Andrew M, AU - Holmes,Jeffrey D, AU - Forwell,Lorie A, AU - Skopelja,Elaine N, AU - Shenton,Martha E, AU - Echlin,Paul S, AU - Koerte,Inga K, Y1 - 2014/01/28/ PY - 2014/1/30/entrez PY - 2014/1/30/pubmed PY - 2014/6/10/medline SP - 882 EP - 90 JF - Journal of neurosurgery JO - J. Neurosurg. VL - 120 IS - 4 N2 - OBJECT: The aim of this study was to examine the brain's white matter microstructure by using MR diffusion tensor imaging (DTI) in ice hockey players with a history of clinically symptomatic concussion compared with players without a history of concussion. METHODS: Sixteen players with a history of concussion (concussed group; mean age 21.7 ± 1.5 years; 6 female) and 18 players without a history of concussion (nonconcussed group; mean age 21.3 ± 1.8 years, 10 female) underwent 3-T DTI at the end of the 2011-2012 Canadian Interuniversity Sports ice hockey season. Tract-based spatial statistics (TBSS) was used to test for group differences in fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and the measure "trace," or mean diffusivity. Cognitive evaluation was performed using the Immediate Postconcussion Assessment and Cognitive Test (ImPACT) and the Sport Concussion Assessment Tool-2 (SCAT2). RESULTS: TBSS revealed a significant increase in FA and AD, and a significant decrease in RD and trace in several brain regions in the concussed group, compared with the nonconcussed group (p < 0.05). The regions with increased FA and decreased RD and trace included the right posterior limb of the internal capsule, the right corona radiata, and the right temporal lobe. Increased AD was observed in a small area in the left corona radiata. The DTI measures correlated with neither the ImPACT nor the SCAT2 scores. CONCLUSIONS: The results of the current study indicate that a history of concussion may result in alterations of the brain's white matter microstructure in ice hockey players. Increased FA based on decreased RD may reflect neuroinflammatory or neuroplastic processes of the brain responding to brain trauma. Future studies are needed that include a longitudinal analysis of the brain's structure and function following a concussion to elucidate further the complex time course of DTI changes and their clinical meaning. SN - 1933-0693 UR - https://www.unboundmedicine.com/medline/citation/24471841/Hockey_Concussion_Education_Project_Part_3__White_matter_microstructure_in_ice_hockey_players_with_a_history_of_concussion:_a_diffusion_tensor_imaging_study_ L2 - https://thejns.org/doi/10.3171/2013.12.JNS132092 DB - PRIME DP - Unbound Medicine ER -