Tags

Type your tag names separated by a space and hit enter

Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers.
Prev Med. 2014 May; 62:1-7.PM

Abstract

OBJECTIVE

We compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs).

METHODS

A cluster randomized clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCWs, was performed in Beijing, China, during the winter season of 2008-2009. Participants were followed for development of clinical respiratory illness (CRI). Symptomatic subjects were tested for Streptococcus pneumoniae, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae or Haemophilus influenza type B by multiplex polymerase chain reaction (PCR).

RESULTS

The rate of bacterial colonization was 2.8% in the N95 group (p=0.02), 5.3% among medical mask users (p<0.01) and 7.5% among the controls (p=0.16). N95 respirators were significantly protective (adjusted RR 0.34, 95% CI: 0.21-0.56) against bacterial colonization. Co-infections of two bacteria or a virus and bacteria occurred in up to 3.7% of HCWs, and were significantly lower in the N95 arm.

CONCLUSIONS

N95 respirators were significantly protective against bacterial colonization, co-colonization and viral-bacterial co-infection. We showed that dual respiratory virus or bacterial-viral co-infections can be reduced by the use of N95 respirators. This study has occupational health and safety implications for health workers.

Authors+Show Affiliations

School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia; National Centre for Immunization Research and Surveillance, The Children's Hospital at Westmead, Sydney, Australia.The Beijing Center for Disease Prevention and Control, Beijing, China.School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia.School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia.School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia; National Centre for Immunization Research and Surveillance, The Children's Hospital at Westmead, Sydney, Australia.School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia.The Beijing Center for Disease Prevention and Control, Beijing, China.The Beijing Center for Disease Prevention and Control, Beijing, China.The Beijing Center for Disease Prevention and Control, Beijing, China.The Beijing Center for Disease Prevention and Control, Beijing, China.School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Australia. Electronic address: a.moa@unsw.edu.au.Centre for Infectious Diseases and Microbiology Laboratory Services, Institute for Clinical Pathology and Medical Research, Westmead Hospital and University of Sydney, Australia.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24472436

Citation

MacIntyre, C Raina, et al. "Efficacy of Face Masks and Respirators in Preventing Upper Respiratory Tract Bacterial Colonization and Co-infection in Hospital Healthcare Workers." Preventive Medicine, vol. 62, 2014, pp. 1-7.
MacIntyre CR, Wang Q, Rahman B, et al. Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers. Prev Med. 2014;62:1-7.
MacIntyre, C. R., Wang, Q., Rahman, B., Seale, H., Ridda, I., Gao, Z., Yang, P., Shi, W., Pang, X., Zhang, Y., Moa, A., & Dwyer, D. E. (2014). Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers. Preventive Medicine, 62, 1-7. https://doi.org/10.1016/j.ypmed.2014.01.015
MacIntyre CR, et al. Efficacy of Face Masks and Respirators in Preventing Upper Respiratory Tract Bacterial Colonization and Co-infection in Hospital Healthcare Workers. Prev Med. 2014;62:1-7. PubMed PMID: 24472436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers. AU - MacIntyre,C Raina, AU - Wang,Quanyi, AU - Rahman,Bayzidur, AU - Seale,Holly, AU - Ridda,Iman, AU - Gao,Zhanhai, AU - Yang,Peng, AU - Shi,Weixian, AU - Pang,Xinghuo, AU - Zhang,Yi, AU - Moa,Aye, AU - Dwyer,Dominic E, Y1 - 2014/01/25/ PY - 2013/08/22/received PY - 2013/12/13/revised PY - 2014/01/15/accepted PY - 2014/1/30/entrez PY - 2014/1/30/pubmed PY - 2015/9/16/medline KW - Bacterial colonization KW - Healthcare workers KW - Hospitals KW - N95 respirators and medical masks SP - 1 EP - 7 JF - Preventive medicine JO - Prev Med VL - 62 N2 - OBJECTIVE: We compared the efficacy of medical masks (MM) and N95 respirators (N95) in preventing bacterial colonization/infection in healthcare workers (HCWs). METHODS: A cluster randomized clinical trial (RCT) of 1441 hospital HCWs randomized to medical masks or N95 respirators, and compared to 481 control HCWs, was performed in Beijing, China, during the winter season of 2008-2009. Participants were followed for development of clinical respiratory illness (CRI). Symptomatic subjects were tested for Streptococcus pneumoniae, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae or Haemophilus influenza type B by multiplex polymerase chain reaction (PCR). RESULTS: The rate of bacterial colonization was 2.8% in the N95 group (p=0.02), 5.3% among medical mask users (p<0.01) and 7.5% among the controls (p=0.16). N95 respirators were significantly protective (adjusted RR 0.34, 95% CI: 0.21-0.56) against bacterial colonization. Co-infections of two bacteria or a virus and bacteria occurred in up to 3.7% of HCWs, and were significantly lower in the N95 arm. CONCLUSIONS: N95 respirators were significantly protective against bacterial colonization, co-colonization and viral-bacterial co-infection. We showed that dual respiratory virus or bacterial-viral co-infections can be reduced by the use of N95 respirators. This study has occupational health and safety implications for health workers. SN - 1096-0260 UR - https://www.unboundmedicine.com/medline/citation/24472436/Efficacy_of_face_masks_and_respirators_in_preventing_upper_respiratory_tract_bacterial_colonization_and_co_infection_in_hospital_healthcare_workers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-7435(14)00032-2 DB - PRIME DP - Unbound Medicine ER -