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HFRS and hantaviruses in the Balkans/South-East Europe.
Virus Res. 2014 Jul 17; 187:27-33.VR

Abstract

Hemorrhagic fever with renal syndrome is endemic in the Balkans with epidemic outbreaks and sporadic cases that have been recorded yearly since the disease was first recognized. The incidence of Balkan HFRS is modest, with approximately one hundred cases reported in most years. Seroepidemiological investigations conducted in several Balkan countries revealed an overall seroprevalence of 6% in Bosnia and Herzegovina, 1.6% in Croatia, 4% in Greece and 1.7% in Slovenia, respectively. The complex ecology of the Balkan Peninsula supports the existence of diverse rodent and insectivore species which harbor several pathogenic and non-pathogenic hantaviruses. Among them only Dobrava (DOBV) and Puumala (PUUV) viruses are associated with disease in humans. Comprehensive clinical studies compared clinical signs and symptoms between patients infected with either virus. A spectrum of clinical picture of the disease ranges from mild illness typical of PUUV infections to a severe form with fulminant hemorrhagic fever and an overall mortality rate of 9.8% among DOBV infected patients. While severe DOBV cases are recognized from Slovenia in the North to Greece in the South, PUUV infections are more frequent in northern part of the area. Balkans represent an area with a potential need for hantavirus vaccines, but due to co-existence of DOBV and PUUV causing HFRS in the same region, a universal vaccine is required.

Authors+Show Affiliations

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Electronic address: tatjana.avsic@mf.uni-lj.si.Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.Research Department, University Hospital for Infectious Diseases, Zagreb, Croatia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24472777

Citation

Avšič Županc, Tatjana, et al. "HFRS and Hantaviruses in the Balkans/South-East Europe." Virus Research, vol. 187, 2014, pp. 27-33.
Avšič Županc T, Korva M, Markotić A. HFRS and hantaviruses in the Balkans/South-East Europe. Virus Res. 2014;187:27-33.
Avšič Županc, T., Korva, M., & Markotić, A. (2014). HFRS and hantaviruses in the Balkans/South-East Europe. Virus Research, 187, 27-33. https://doi.org/10.1016/j.virusres.2013.12.042
Avšič Županc T, Korva M, Markotić A. HFRS and Hantaviruses in the Balkans/South-East Europe. Virus Res. 2014 Jul 17;187:27-33. PubMed PMID: 24472777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HFRS and hantaviruses in the Balkans/South-East Europe. AU - Avšič Županc,Tatjana, AU - Korva,Miša, AU - Markotić,Alemka, Y1 - 2014/01/26/ PY - 2013/10/03/received PY - 2013/11/26/revised PY - 2013/12/24/accepted PY - 2014/1/30/entrez PY - 2014/1/30/pubmed PY - 2015/2/20/medline KW - Balkan KW - HFRS KW - Hantavirus KW - South-East Europe SP - 27 EP - 33 JF - Virus research JO - Virus Res. VL - 187 N2 - Hemorrhagic fever with renal syndrome is endemic in the Balkans with epidemic outbreaks and sporadic cases that have been recorded yearly since the disease was first recognized. The incidence of Balkan HFRS is modest, with approximately one hundred cases reported in most years. Seroepidemiological investigations conducted in several Balkan countries revealed an overall seroprevalence of 6% in Bosnia and Herzegovina, 1.6% in Croatia, 4% in Greece and 1.7% in Slovenia, respectively. The complex ecology of the Balkan Peninsula supports the existence of diverse rodent and insectivore species which harbor several pathogenic and non-pathogenic hantaviruses. Among them only Dobrava (DOBV) and Puumala (PUUV) viruses are associated with disease in humans. Comprehensive clinical studies compared clinical signs and symptoms between patients infected with either virus. A spectrum of clinical picture of the disease ranges from mild illness typical of PUUV infections to a severe form with fulminant hemorrhagic fever and an overall mortality rate of 9.8% among DOBV infected patients. While severe DOBV cases are recognized from Slovenia in the North to Greece in the South, PUUV infections are more frequent in northern part of the area. Balkans represent an area with a potential need for hantavirus vaccines, but due to co-existence of DOBV and PUUV causing HFRS in the same region, a universal vaccine is required. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/24472777/HFRS_and_hantaviruses_in_the_Balkans/South_East_Europe_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(13)00488-7 DB - PRIME DP - Unbound Medicine ER -