Tags

Type your tag names separated by a space and hit enter

Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats.
J Physiol Biochem. 2014 Jun; 70(2):311-20.JP

Abstract

The main aim of this study was to investigate the beneficial effects of hydro-alcoholic extract of Caralluma fimbriata (CFE) on the effects of high-fat diet feeding on insulin resistance and oxidative stress in Wistar rats. High-fat diet (60% of fat) and CFE (200 mg/kg body weight/day) were given concurrently to the rats for a period of 90 days. Feeding with high-fat diet resulted in the development of hyperglycemia, hyperinsulinemia, hyperleptinemia, and hypertriglyceridemia and impaired insulin sensitivity (P < 0.05). Administration of CFE to high-fat diet-fed rats for 90 days resulted in a significant improvement in plasma glucose, insulin, leptin, and triglycerides. Regarding liver antioxidant status, high-fat fed rats showed higher levels of lipid peroxidation, protein oxidation and lower GSH levels and lower activities of enzymatic antioxidants, while CFE treatment prevented all these observed abnormalities. In conclusion, intake of CFE may be beneficial for the suppression of high-fat diet-induced insulin resistance and oxidative stress.

Authors+Show Affiliations

Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, 515003, Andhra Pradesh, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24474087

Citation

Sudhakara, G, et al. "Beneficial Effects of Hydro-alcoholic Extract of Caralluma Fimbriata Against High-fat Diet-induced Insulin Resistance and Oxidative Stress in Wistar Male Rats." Journal of Physiology and Biochemistry, vol. 70, no. 2, 2014, pp. 311-20.
Sudhakara G, Mallaiah P, Sreenivasulu N, et al. Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats. J Physiol Biochem. 2014;70(2):311-20.
Sudhakara, G., Mallaiah, P., Sreenivasulu, N., Sasi Bhusana Rao, B., Rajendran, R., & Saralakumari, D. (2014). Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats. Journal of Physiology and Biochemistry, 70(2), 311-20. https://doi.org/10.1007/s13105-013-0304-1
Sudhakara G, et al. Beneficial Effects of Hydro-alcoholic Extract of Caralluma Fimbriata Against High-fat Diet-induced Insulin Resistance and Oxidative Stress in Wistar Male Rats. J Physiol Biochem. 2014;70(2):311-20. PubMed PMID: 24474087.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of hydro-alcoholic extract of Caralluma fimbriata against high-fat diet-induced insulin resistance and oxidative stress in Wistar male rats. AU - Sudhakara,G, AU - Mallaiah,P, AU - Sreenivasulu,N, AU - Sasi Bhusana Rao,B, AU - Rajendran,R, AU - Saralakumari,D, Y1 - 2014/01/29/ PY - 2013/04/20/received PY - 2013/12/02/accepted PY - 2014/1/30/entrez PY - 2014/1/30/pubmed PY - 2015/1/3/medline SP - 311 EP - 20 JF - Journal of physiology and biochemistry JO - J Physiol Biochem VL - 70 IS - 2 N2 - The main aim of this study was to investigate the beneficial effects of hydro-alcoholic extract of Caralluma fimbriata (CFE) on the effects of high-fat diet feeding on insulin resistance and oxidative stress in Wistar rats. High-fat diet (60% of fat) and CFE (200 mg/kg body weight/day) were given concurrently to the rats for a period of 90 days. Feeding with high-fat diet resulted in the development of hyperglycemia, hyperinsulinemia, hyperleptinemia, and hypertriglyceridemia and impaired insulin sensitivity (P < 0.05). Administration of CFE to high-fat diet-fed rats for 90 days resulted in a significant improvement in plasma glucose, insulin, leptin, and triglycerides. Regarding liver antioxidant status, high-fat fed rats showed higher levels of lipid peroxidation, protein oxidation and lower GSH levels and lower activities of enzymatic antioxidants, while CFE treatment prevented all these observed abnormalities. In conclusion, intake of CFE may be beneficial for the suppression of high-fat diet-induced insulin resistance and oxidative stress. SN - 1877-8755 UR - https://www.unboundmedicine.com/medline/citation/24474087/Beneficial_effects_of_hydro_alcoholic_extract_of_Caralluma_fimbriata_against_high_fat_diet_induced_insulin_resistance_and_oxidative_stress_in_Wistar_male_rats_ L2 - https://dx.doi.org/10.1007/s13105-013-0304-1 DB - PRIME DP - Unbound Medicine ER -