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Chemical composition of the essential oil of Lippia gracilis Schauer leaves and its potential as modulator of bacterial resistance.
Nat Prod Res. 2014; 28(6):399-402.NP

Abstract

Lippia gracilis Schauer (Verbenaceae) is an aromatic plant widely used in folk medicine in the Brazilian semi-arid region. This work aims at evaluating the anti-microbial activity of essential oils from the leaves of L. gracilis (EOLG) when associated with commercial antibiotics against bacterial resistance. The essential oil obtained by hydrodistillation has 38 chemical constituents with thymol (44.4%), carvacrol (22.2%), p-cymene (6.2%) and α-pinene (5.6%) as major constituents. Microbiological assays were conducted by direct and gaseous contacts. We demonstrated that EOLG has significant synergism with all antibiotics tested. EOLG decreased the minimal inhibitory concentration of the aminoglycosides and improved their zone of inhibition more than 300% against Staphylococcus aureus and 270% against Pseudomonas aeruginosa. These results demonstrate that natural substances present in EOLG have the capacity to modulate bacterial resistance and can be used as an adjuvant therapy against multi-resistant microorganisms such as S. aureus, Escherichia coli and P. aeruginosa.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Bitu Vde C
a Faculdade Leão Sampaio, Unidade Saúde , Juazeiro do Norte , Brazil.
Fecundo HD
No affiliation info available
da Costa JG
No affiliation info available
Coutinho HD
No affiliation info available
Rodrigues FF
No affiliation info available
de Santana NM
No affiliation info available
Botelho MA
No affiliation info available
Menezes IR
No affiliation info available

MeSH

AminoglycosidesAnti-Bacterial AgentsBicyclic MonoterpenesBrazilCymenesGas Chromatography-Mass SpectrometryLippiaMicrobial Sensitivity TestsMonoterpenesOils, VolatilePlant LeavesPlant OilsPseudomonas aeruginosaStaphylococcus aureusThymol

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24479735

Citation

Bitu, Vanessa de Carvalho Nilo, et al. "Chemical Composition of the Essential Oil of Lippia Gracilis Schauer Leaves and Its Potential as Modulator of Bacterial Resistance." Natural Product Research, vol. 28, no. 6, 2014, pp. 399-402.
Bitu Vde C, Fecundo HD, da Costa JG, et al. Chemical composition of the essential oil of Lippia gracilis Schauer leaves and its potential as modulator of bacterial resistance. Nat Prod Res. 2014;28(6):399-402.
Bitu, V. d. e. . C., Fecundo, H. D., da Costa, J. G., Coutinho, H. D., Rodrigues, F. F., de Santana, N. M., Botelho, M. A., & Menezes, I. R. (2014). Chemical composition of the essential oil of Lippia gracilis Schauer leaves and its potential as modulator of bacterial resistance. Natural Product Research, 28(6), 399-402. https://doi.org/10.1080/14786419.2013.867343
Bitu Vde C, et al. Chemical Composition of the Essential Oil of Lippia Gracilis Schauer Leaves and Its Potential as Modulator of Bacterial Resistance. Nat Prod Res. 2014;28(6):399-402. PubMed PMID: 24479735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition of the essential oil of Lippia gracilis Schauer leaves and its potential as modulator of bacterial resistance. AU - Bitu,Vanessa de Carvalho Nilo, AU - Fecundo,Heberty Di Tarso Fernandes, AU - da Costa,José Galberto Martins, AU - Coutinho,Henrique Douglas Melo, AU - Rodrigues,Fabíola Fernandes G, AU - de Santana,Nathalia Matos, AU - Botelho,Marco Antônio, AU - Menezes,Irwin R Alencar, Y1 - 2014/01/31/ PY - 2014/2/1/entrez PY - 2014/2/1/pubmed PY - 2014/11/2/medline SP - 399 EP - 402 JF - Natural product research JO - Nat Prod Res VL - 28 IS - 6 N2 - Lippia gracilis Schauer (Verbenaceae) is an aromatic plant widely used in folk medicine in the Brazilian semi-arid region. This work aims at evaluating the anti-microbial activity of essential oils from the leaves of L. gracilis (EOLG) when associated with commercial antibiotics against bacterial resistance. The essential oil obtained by hydrodistillation has 38 chemical constituents with thymol (44.4%), carvacrol (22.2%), p-cymene (6.2%) and α-pinene (5.6%) as major constituents. Microbiological assays were conducted by direct and gaseous contacts. We demonstrated that EOLG has significant synergism with all antibiotics tested. EOLG decreased the minimal inhibitory concentration of the aminoglycosides and improved their zone of inhibition more than 300% against Staphylococcus aureus and 270% against Pseudomonas aeruginosa. These results demonstrate that natural substances present in EOLG have the capacity to modulate bacterial resistance and can be used as an adjuvant therapy against multi-resistant microorganisms such as S. aureus, Escherichia coli and P. aeruginosa. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/24479735/Chemical_composition_of_the_essential_oil_of_Lippia_gracilis_Schauer_leaves_and_its_potential_as_modulator_of_bacterial_resistance_ DB - PRIME DP - Unbound Medicine ER -