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Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study.
Br J Cancer 2014; 110(5):1328-33BJ

Abstract

BACKGROUND

Nutrients in the one-carbon metabolism pathway may be involved in carcinogenesis. Few cohort studies have investigated the intakes of folate and related nutrients in relation to gastric and esophageal cancer.

METHODS

We prospectively examined the association between self-reported intakes of folate, methionine, vitamin B6, and vitamin B12 and gastric and esophageal cancer in 492,293 men and women.

RESULTS

We observed an elevated risk of esophageal squamous cell carcinoma with low intake of folate (relative risk (95% confidence interval): Q1 vs Q3, 1.91 (1.17, 3.10)), but no association with high intake. Folate intake was not associated with esophageal adenocarcinoma, gastric cardia adenocarcinoma, or non-cardia gastric adenocarcinoma. The intakes of methionine, vitamin B6, and vitamin B12 were not associated with esophageal and gastric cancer.

CONCLUSION

Low intake of folate was associated with increased risk of esophageal squamous cell carcinoma.

Authors+Show Affiliations

Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.National Office for Cancer Prevention and Control, National Cancer Center, Beijing, China.AARP, Washington, District of Columbia, USA.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

24481406

Citation

Xiao, Q, et al. "Intakes of Folate, Methionine, Vitamin B6, and Vitamin B12 With Risk of Esophageal and Gastric Cancer in a Large Cohort Study." British Journal of Cancer, vol. 110, no. 5, 2014, pp. 1328-33.
Xiao Q, Freedman ND, Ren J, et al. Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study. Br J Cancer. 2014;110(5):1328-33.
Xiao, Q., Freedman, N. D., Ren, J., Hollenbeck, A. R., Abnet, C. C., & Park, Y. (2014). Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study. British Journal of Cancer, 110(5), pp. 1328-33. doi:10.1038/bjc.2014.17.
Xiao Q, et al. Intakes of Folate, Methionine, Vitamin B6, and Vitamin B12 With Risk of Esophageal and Gastric Cancer in a Large Cohort Study. Br J Cancer. 2014 Mar 4;110(5):1328-33. PubMed PMID: 24481406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study. AU - Xiao,Q, AU - Freedman,N D, AU - Ren,J, AU - Hollenbeck,A R, AU - Abnet,C C, AU - Park,Y, Y1 - 2014/01/30/ PY - 2013/09/25/received PY - 2013/12/20/revised PY - 2013/12/25/accepted PY - 2014/2/1/entrez PY - 2014/2/1/pubmed PY - 2014/6/24/medline SP - 1328 EP - 33 JF - British journal of cancer JO - Br. J. Cancer VL - 110 IS - 5 N2 - BACKGROUND: Nutrients in the one-carbon metabolism pathway may be involved in carcinogenesis. Few cohort studies have investigated the intakes of folate and related nutrients in relation to gastric and esophageal cancer. METHODS: We prospectively examined the association between self-reported intakes of folate, methionine, vitamin B6, and vitamin B12 and gastric and esophageal cancer in 492,293 men and women. RESULTS: We observed an elevated risk of esophageal squamous cell carcinoma with low intake of folate (relative risk (95% confidence interval): Q1 vs Q3, 1.91 (1.17, 3.10)), but no association with high intake. Folate intake was not associated with esophageal adenocarcinoma, gastric cardia adenocarcinoma, or non-cardia gastric adenocarcinoma. The intakes of methionine, vitamin B6, and vitamin B12 were not associated with esophageal and gastric cancer. CONCLUSION: Low intake of folate was associated with increased risk of esophageal squamous cell carcinoma. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/24481406/Intakes_of_folate_methionine_vitamin_B6_and_vitamin_B12_with_risk_of_esophageal_and_gastric_cancer_in_a_large_cohort_study_ L2 - http://dx.doi.org/10.1038/bjc.2014.17 DB - PRIME DP - Unbound Medicine ER -