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Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
J Oral Facial Pain Headache. 2014 Winter; 28(1):61-7.JO

Abstract

AIMS

To clarify the antiallodynic effects of the α2-adrenergic receptor antagonist mirtazapine compared with those of gabapentin and pregabalin in a rat model of orofacial neuropathic pain.

METHODS

Mirtazapine (10, 30, and 100 μg), gabapentin (10, 30, and 100 μg), and pregabalin (3, 10, and 30 μg) were administered intrathecally to eight male Sprague-Dawley rats with orofacial neuropathic pain induced by chronic constriction injury of the infraorbital nerve that had been carried out 2 weeks previously. Stimulation using von Frey filaments (1.0 to 15.0 g) applied to skin innervated by the injured infraorbital nerve enabled the measurement of mechanical thresholds 0 to 180 minutes after drug injection. Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test.

RESULTS

Intrathecal administration of not only gabapentin and pregabalin but also mirtazapine reversed the lowered mechanical nociceptive thresholds produced by the nerve injury. The ED50 (95% confidence interval) was (in μg) 49.00 (39.71-58.29) for mirtazapine, 54.84 (46.12-63.56) for gabapentin, and 13.47 (11.24-15.69) for pregabalin.

CONCLUSION

Intraspinal administration of either mirtazapine, gabapentin, or pregabalin reverses the lowered facial mechanical thresholds produced in a rat model of trigeminal neuropathic pain.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24482789

Citation

Nakai, Kunihiro, et al. "Antinociceptive Effects of Mirtazapine, Pregabalin, and Gabapentin After Chronic Constriction Injury of the Infraorbital Nerve in Rats." Journal of Oral & Facial Pain and Headache, vol. 28, no. 1, 2014, pp. 61-7.
Nakai K, Nakae A, Hashimoto R, et al. Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. J Oral Facial Pain Headache. 2014;28(1):61-7.
Nakai, K., Nakae, A., Hashimoto, R., Mashimo, T., & Hosokawa, K. (2014). Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. Journal of Oral & Facial Pain and Headache, 28(1), 61-7. https://doi.org/10.11607/jop.1105
Nakai K, et al. Antinociceptive Effects of Mirtazapine, Pregabalin, and Gabapentin After Chronic Constriction Injury of the Infraorbital Nerve in Rats. J Oral Facial Pain Headache. 2014;28(1):61-7. PubMed PMID: 24482789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. AU - Nakai,Kunihiro, AU - Nakae,Aya, AU - Hashimoto,Ryota, AU - Mashimo,Takashi, AU - Hosokawa,Ko, PY - 2014/2/1/entrez PY - 2014/2/1/pubmed PY - 2014/4/25/medline SP - 61 EP - 7 JF - Journal of oral & facial pain and headache JO - J Oral Facial Pain Headache VL - 28 IS - 1 N2 - AIMS: To clarify the antiallodynic effects of the α2-adrenergic receptor antagonist mirtazapine compared with those of gabapentin and pregabalin in a rat model of orofacial neuropathic pain. METHODS: Mirtazapine (10, 30, and 100 μg), gabapentin (10, 30, and 100 μg), and pregabalin (3, 10, and 30 μg) were administered intrathecally to eight male Sprague-Dawley rats with orofacial neuropathic pain induced by chronic constriction injury of the infraorbital nerve that had been carried out 2 weeks previously. Stimulation using von Frey filaments (1.0 to 15.0 g) applied to skin innervated by the injured infraorbital nerve enabled the measurement of mechanical thresholds 0 to 180 minutes after drug injection. Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test. RESULTS: Intrathecal administration of not only gabapentin and pregabalin but also mirtazapine reversed the lowered mechanical nociceptive thresholds produced by the nerve injury. The ED50 (95% confidence interval) was (in μg) 49.00 (39.71-58.29) for mirtazapine, 54.84 (46.12-63.56) for gabapentin, and 13.47 (11.24-15.69) for pregabalin. CONCLUSION: Intraspinal administration of either mirtazapine, gabapentin, or pregabalin reverses the lowered facial mechanical thresholds produced in a rat model of trigeminal neuropathic pain. SN - 2333-0384 UR - https://www.unboundmedicine.com/medline/citation/24482789/Antinociceptive_effects_of_mirtazapine_pregabalin_and_gabapentin_after_chronic_constriction_injury_of_the_infraorbital_nerve_in_rats_ L2 - https://doi.org/10.11607/jop.1105 DB - PRIME DP - Unbound Medicine ER -