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[Reasons for abandonment of hormone replacement therapy with tibolone in menopausal women].

Abstract

BACKGROUND

Hormone replacement therapy (HRT) with tibolone used in the management of menopause has low rates of acceptance and compliance in the first year. Few studies analyze the reasons for abandoning the use of tibolone.

OBJECTIVE

To analyze the reasons for abandoned tibolone hormone replacement therapy in postmenopausal women and the effects of the drug through the years in the treatment.

MATERIAL AND METHODS

In a cross-sectional study, were included 261 menopausal women between 40 and 60 year old who attended their disease control at the Gynaecological Endocrinology serving in the National Medical Center Northwest in Obregon City, Sonora, Mexico during 2010-2011. The variables studied included: age, type of menopause, time of use of HRT with tibolone, abandonment reason, development of hypertension, dyslipidemia, hypothyroidism and diabetes mellitus.

RESULTS

A total of 21 women discontinued treatment (8.60%, 95% CI -3 to 19), p=0.0001. The reasons for abandonment included, 42.9% gynecological reasons (23.8% breast disease, 14.3% and 4.8% cervical condition ovarian pathology, p=0.0001). Liver disease and vascular occurred in 28.6%, p=0.050.

CONCLUSION

The women studied have adequate adherence to treatment with tibolone (>90%). We don't show an increased risk of cardiovascular or metabolic disease in women studied. Further studies are needed to explore the long-term clinical course, therapeutic response and complications in menopausal patients who use HRT with tibolone.

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    Source

    Ginecología y obstetricia de México 81:10 2013 Oct pg 593-601

    MeSH

    Adult
    Cross-Sectional Studies
    Estrogen Receptor Modulators
    Estrogen Replacement Therapy
    Female
    Humans
    Medication Adherence
    Menopause
    Mexico
    Middle Aged
    Norpregnenes

    Pub Type(s)

    English Abstract
    Journal Article

    Language

    spa

    PubMed ID

    24483042

    Citation

    TY - JOUR T1 - [Reasons for abandonment of hormone replacement therapy with tibolone in menopausal women]. AU - Zayas-Jaime,Francisco Javier, AU - Ornelas-Aguirre,José Manuel, AU - Pérez-Nápoles,Dalia Elizabeth, PY - 2014/2/4/entrez PY - 2014/2/4/pubmed PY - 2014/2/25/medline SP - 593 EP - 601 JF - Ginecología y obstetricia de México JO - Ginecol Obstet Mex VL - 81 IS - 10 N2 - BACKGROUND: Hormone replacement therapy (HRT) with tibolone used in the management of menopause has low rates of acceptance and compliance in the first year. Few studies analyze the reasons for abandoning the use of tibolone. OBJECTIVE: To analyze the reasons for abandoned tibolone hormone replacement therapy in postmenopausal women and the effects of the drug through the years in the treatment. MATERIAL AND METHODS: In a cross-sectional study, were included 261 menopausal women between 40 and 60 year old who attended their disease control at the Gynaecological Endocrinology serving in the National Medical Center Northwest in Obregon City, Sonora, Mexico during 2010-2011. The variables studied included: age, type of menopause, time of use of HRT with tibolone, abandonment reason, development of hypertension, dyslipidemia, hypothyroidism and diabetes mellitus. RESULTS: A total of 21 women discontinued treatment (8.60%, 95% CI -3 to 19), p=0.0001. The reasons for abandonment included, 42.9% gynecological reasons (23.8% breast disease, 14.3% and 4.8% cervical condition ovarian pathology, p=0.0001). Liver disease and vascular occurred in 28.6%, p=0.050. CONCLUSION: The women studied have adequate adherence to treatment with tibolone (>90%). We don't show an increased risk of cardiovascular or metabolic disease in women studied. Further studies are needed to explore the long-term clinical course, therapeutic response and complications in menopausal patients who use HRT with tibolone. SN - 0300-9041 UR - https://www.unboundmedicine.com/medline/citation/24483042/[Reasons_for_abandonment_of_hormone_replacement_therapy_with_tibolone_in_menopausal_women]_ L2 - http://openurl.ebscohost.com/linksvc/linking.aspx?genre=article&sid=PubMed&issn=0300-9041&title=Ginecol Obstet Mex&volume=81&issue=10&spage=593&atitle=[Reasons for abandonment of hormone replacement therapy with tibolone in menopausal women].&aulast=Zayas-Jaime&date=2013 ER -