Tags

Type your tag names separated by a space and hit enter

A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition.
Mol Neurodegener. 2014 Feb 03; 9:10.MN

Abstract

BACKGROUND

Identification and quantification of fibrillar amyloid in brain using positron emission tomography (PET) imaging and Amyvid™ ([18 F] Amyvid, [18 F] florbetapir, 18 F-AV-45) was recently approved by the US Food and Drug Administration as a clinical tool to estimate brain amyloid burden in patients being evaluated for cognitive impairment or dementia. Imaging with [18 F] florbetapir offers in vivo confirmation of the presence of cerebral amyloidosis and may increase the accuracy of the diagnosis and likely cause of cognitive impairment (CI) or dementia. Most importantly, amyloid imaging may improve certainty of etiology in situations where the differential diagnosis cannot be resolved on the basis of standard clinical and laboratory criteria.

RESULTS

A consecutive case series of 30 patients (age 50-89; 16 M/14 F) were clinically evaluated at a cognitive evaluation center of urban dementia center and referred for [18 F] florbetapir PET imaging as part of a comprehensive dementia workup. Evaluation included neurological examination and neuropsychological assessment by dementia experts. [18 F] florbetapir PET scans were read by trained nuclear medicine physicians using the qualitative binary approach. Scans were rated as either positive or negative for the presence of cerebral amyloidosis. In addition to a comprehensive dementia evaluation, post [18 F] florbetapir PET imaging results caused diagnoses to be changed in 10 patients and clarified in 9 patients. Four patients presenting with SCI were negative for amyloidosis. These results show that [18 F] florbetapir PET imaging added diagnostic clarification and discrimination in over half of the patients evaluated.

CONCLUSIONS

Amyloid imaging provided novel and essential data that: (1) caused diagnosis to be revised; and/or (2) prevented the initiation of incorrect or suboptimal treatment; and/or (3) avoided inappropriate referral to an anti-amyloid clinical trial.

Authors+Show Affiliations

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L, Levy Place, Box 1230, New York, NY 10029, USA. effie.mitsis@mssm.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24484858

Citation

Mitsis, Effie M., et al. "A Consecutive Case Series Experience With [18 F] Florbetapir PET Imaging in an Urban Dementia Center: Impact On Quality of Life, Decision Making, and Disposition." Molecular Neurodegeneration, vol. 9, 2014, p. 10.
Mitsis EM, Bender HA, Kostakoglu L, et al. A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition. Mol Neurodegener. 2014;9:10.
Mitsis, E. M., Bender, H. A., Kostakoglu, L., Machac, J., Martin, J., Woehr, J. L., Sewell, M. C., Aloysi, A., Goldstein, M. A., Li, C., Sano, M., & Gandy, S. (2014). A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition. Molecular Neurodegeneration, 9, 10. https://doi.org/10.1186/1750-1326-9-10
Mitsis EM, et al. A Consecutive Case Series Experience With [18 F] Florbetapir PET Imaging in an Urban Dementia Center: Impact On Quality of Life, Decision Making, and Disposition. Mol Neurodegener. 2014 Feb 3;9:10. PubMed PMID: 24484858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition. AU - Mitsis,Effie M, AU - Bender,Heidi A, AU - Kostakoglu,Lale, AU - Machac,Josef, AU - Martin,Jane, AU - Woehr,Jennifer L, AU - Sewell,Margaret C, AU - Aloysi,Amy, AU - Goldstein,Martin A, AU - Li,Clara, AU - Sano,Mary, AU - Gandy,Sam, Y1 - 2014/02/03/ PY - 2013/12/31/received PY - 2014/01/30/accepted PY - 2014/2/4/entrez PY - 2014/2/4/pubmed PY - 2014/9/13/medline SP - 10 EP - 10 JF - Molecular neurodegeneration JO - Mol Neurodegener VL - 9 N2 - BACKGROUND: Identification and quantification of fibrillar amyloid in brain using positron emission tomography (PET) imaging and Amyvid™ ([18 F] Amyvid, [18 F] florbetapir, 18 F-AV-45) was recently approved by the US Food and Drug Administration as a clinical tool to estimate brain amyloid burden in patients being evaluated for cognitive impairment or dementia. Imaging with [18 F] florbetapir offers in vivo confirmation of the presence of cerebral amyloidosis and may increase the accuracy of the diagnosis and likely cause of cognitive impairment (CI) or dementia. Most importantly, amyloid imaging may improve certainty of etiology in situations where the differential diagnosis cannot be resolved on the basis of standard clinical and laboratory criteria. RESULTS: A consecutive case series of 30 patients (age 50-89; 16 M/14 F) were clinically evaluated at a cognitive evaluation center of urban dementia center and referred for [18 F] florbetapir PET imaging as part of a comprehensive dementia workup. Evaluation included neurological examination and neuropsychological assessment by dementia experts. [18 F] florbetapir PET scans were read by trained nuclear medicine physicians using the qualitative binary approach. Scans were rated as either positive or negative for the presence of cerebral amyloidosis. In addition to a comprehensive dementia evaluation, post [18 F] florbetapir PET imaging results caused diagnoses to be changed in 10 patients and clarified in 9 patients. Four patients presenting with SCI were negative for amyloidosis. These results show that [18 F] florbetapir PET imaging added diagnostic clarification and discrimination in over half of the patients evaluated. CONCLUSIONS: Amyloid imaging provided novel and essential data that: (1) caused diagnosis to be revised; and/or (2) prevented the initiation of incorrect or suboptimal treatment; and/or (3) avoided inappropriate referral to an anti-amyloid clinical trial. SN - 1750-1326 UR - https://www.unboundmedicine.com/medline/citation/24484858/A_consecutive_case_series_experience_with_[18_F]_florbetapir_PET_imaging_in_an_urban_dementia_center:_impact_on_quality_of_life_decision_making_and_disposition_ L2 - https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-9-10 DB - PRIME DP - Unbound Medicine ER -