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Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction.
Fertil Steril. 2014 Apr; 101(4):1019-25.FS

Abstract

OBJECTIVE

To examine differences in maternal characteristics and pregnancy outcomes between women with ovulatory dysfunction (OD) and women with tubal obstruction (TO) who underwent assisted reproductive technology (ART).

DESIGN

Retrospective cohort study.

SETTING

Centers for Disease Control and Prevention.

PATIENT(S)

Exposed and nonexposed groups were selected from the 2000-2006 National ART Surveillance System linked with live-birth certificates from three states: Florida, Massachusetts, and Michigan.

INTERVENTION(S)

None.

MAIN OUTCOME MEASURE(S)

Maternal characteristics and pregnancy outcomes, including newborn's health status right after delivery (Apgar score, <7 vs. ≥ 7) as the study outcome of interest, were assessed among women with OD/polycystic ovary syndrome (PCOS) and TO who used ART.

RESULT(S)

A significantly higher prevalence of women with OD/PCOS were younger (<35 years of age; 65.7% vs. 48.9%), were white (85.4% vs. 74.4%), had higher education (29.4% vs. 15.6%), and experienced diabetes (8.8% vs. 5.3%) compared with those having TO. The odds of having a lower (<7) Apgar score at 5 minutes were almost twice as high among newborns of women with OD/PCOS compared with those with TO (crude odds ratio, 1.86; 95% confidence interval [CI], 1.31, 2.64; adjusted odds ratio, 1.90; 95% CI, 1.30, 2.77).

CONCLUSION(S)

Women with OD/PCOS who underwent ART have different characteristics and health issues (higher prevalence of diabetes) and infant outcomes (lower Apgar score) compared with women with TO.

Authors+Show Affiliations

Centers for Disease Control and Prevention, Atlanta, Georgia. Electronic address: vgrigorescu@cdc.gov.Centers for Disease Control and Prevention, Atlanta, Georgia.Centers for Disease Control and Prevention, Atlanta, Georgia.Centers for Disease Control and Prevention, Atlanta, Georgia.Centers for Disease Control and Prevention, Atlanta, Georgia.College of Public Health, University of South Florida, Tampa, Florida.Massachusetts Department of Public Health, Boston, Massachusetts.Michigan Department of Community Health, Lansing, Michigan.Centers for Disease Control and Prevention, Atlanta, Georgia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

24484993

Citation

Grigorescu, Violanda, et al. "Maternal Characteristics and Pregnancy Outcomes After Assisted Reproductive Technology By Infertility Diagnosis: Ovulatory Dysfunction Versus Tubal Obstruction." Fertility and Sterility, vol. 101, no. 4, 2014, pp. 1019-25.
Grigorescu V, Zhang Y, Kissin DM, et al. Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction. Fertil Steril. 2014;101(4):1019-25.
Grigorescu, V., Zhang, Y., Kissin, D. M., Sauber-Schatz, E., Sunderam, M., Kirby, R. S., Diop, H., McKane, P., & Jamieson, D. J. (2014). Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction. Fertility and Sterility, 101(4), 1019-25. https://doi.org/10.1016/j.fertnstert.2013.12.030
Grigorescu V, et al. Maternal Characteristics and Pregnancy Outcomes After Assisted Reproductive Technology By Infertility Diagnosis: Ovulatory Dysfunction Versus Tubal Obstruction. Fertil Steril. 2014;101(4):1019-25. PubMed PMID: 24484993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction. AU - Grigorescu,Violanda, AU - Zhang,Yujia, AU - Kissin,Dmitry M, AU - Sauber-Schatz,Erin, AU - Sunderam,Mithi, AU - Kirby,Russell S, AU - Diop,Hafsatou, AU - McKane,Patricia, AU - Jamieson,Denise J, Y1 - 2014/01/30/ PY - 2013/04/24/received PY - 2013/12/09/revised PY - 2013/12/16/accepted PY - 2014/2/4/entrez PY - 2014/2/4/pubmed PY - 2014/6/3/medline KW - Apgar score KW - Ovulatory dysfunction (OD) KW - assisted reproductive technology (ART) KW - polycystic ovary syndrome (PCOS) KW - tubal obstruction (TO) SP - 1019 EP - 25 JF - Fertility and sterility JO - Fertil. Steril. VL - 101 IS - 4 N2 - OBJECTIVE: To examine differences in maternal characteristics and pregnancy outcomes between women with ovulatory dysfunction (OD) and women with tubal obstruction (TO) who underwent assisted reproductive technology (ART). DESIGN: Retrospective cohort study. SETTING: Centers for Disease Control and Prevention. PATIENT(S): Exposed and nonexposed groups were selected from the 2000-2006 National ART Surveillance System linked with live-birth certificates from three states: Florida, Massachusetts, and Michigan. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Maternal characteristics and pregnancy outcomes, including newborn's health status right after delivery (Apgar score, <7 vs. ≥ 7) as the study outcome of interest, were assessed among women with OD/polycystic ovary syndrome (PCOS) and TO who used ART. RESULT(S): A significantly higher prevalence of women with OD/PCOS were younger (<35 years of age; 65.7% vs. 48.9%), were white (85.4% vs. 74.4%), had higher education (29.4% vs. 15.6%), and experienced diabetes (8.8% vs. 5.3%) compared with those having TO. The odds of having a lower (<7) Apgar score at 5 minutes were almost twice as high among newborns of women with OD/PCOS compared with those with TO (crude odds ratio, 1.86; 95% confidence interval [CI], 1.31, 2.64; adjusted odds ratio, 1.90; 95% CI, 1.30, 2.77). CONCLUSION(S): Women with OD/PCOS who underwent ART have different characteristics and health issues (higher prevalence of diabetes) and infant outcomes (lower Apgar score) compared with women with TO. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/24484993/Maternal_characteristics_and_pregnancy_outcomes_after_assisted_reproductive_technology_by_infertility_diagnosis:_ovulatory_dysfunction_versus_tubal_obstruction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(13)03462-6 DB - PRIME DP - Unbound Medicine ER -