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Stroke risk and outcomes in patients with traumatic brain injury: 2 nationwide studies.
Mayo Clin Proc 2014; 89(2):163-72MC

Abstract

OBJECTIVE

To investigate whether patients with traumatic brain injury (TBI) have an increased risk of stroke or poststroke mortality.

PARTICIPANTS AND METHODS

Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study of 30,165 patients with new TBI and 120,660 persons without TBI between January 1, 2000, and December 31, 2004. The risk of stroke was compared between 2 cohorts through December 31, 2008. To investigate the association between in-hospital mortality after stroke and history of TBI, we conducted a case-control study of 7751 patients with newly diagnosed stroke between January 1, 2005, and December 31, 2008.

RESULTS

The TBI cohort had an increased stroke risk (hazard ratio [HR], 1.98; 95% CI, 1.86-2.11). Among patients with stroke, those with a history of TBI had a higher risk of poststroke mortality compared with those without TBI (odds ratio, 1.57; 95% CI, 1.13-2.19). In the TBI cohort, factors associated with stroke were history of TBI hospitalization (HR, 3.14; 95% CI, 2.77-3.56), emergency care for TBI (HR, 3.37; 95% CI, 2.88-3.95), brain hemorrhage (HR, 2.69; 95% CI, 2.43-2.99), skull fracture (HR, 3.00; 95% CI, 2.42-3.71), low income (HR, 2.65; 95% CI, 2.16-3.25), and high medical expenditure for TBI care (HR, 2.26; 95% CI, 2.09-2.43). The severity of TBI was also correlated with poststroke mortality.

CONCLUSIONS

Traumatic brain injury was associated with risk of stroke and poststroke mortality. The relationship between TBI and poststroke mortality does not seem to transcend all age groups. This research shows the importance of prevention, early recognition, and treatment of stroke in this vulnerable population.

Authors+Show Affiliations

Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan; School of Medicine, Taipei Medical University, Taipei, Taiwan.Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan.School of Medicine, Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan.Department of Anesthesiology, Taipei Medical University Hospital, Taipei, Taiwan; Health Policy Research Center, Taipei Medical University Hospital, Taipei, Taiwan; School of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: tlc@tmu.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24485130

Citation

Liao, Chien-Chang, et al. "Stroke Risk and Outcomes in Patients With Traumatic Brain Injury: 2 Nationwide Studies." Mayo Clinic Proceedings, vol. 89, no. 2, 2014, pp. 163-72.
Liao CC, Chou YC, Yeh CC, et al. Stroke risk and outcomes in patients with traumatic brain injury: 2 nationwide studies. Mayo Clin Proc. 2014;89(2):163-72.
Liao, C. C., Chou, Y. C., Yeh, C. C., Hu, C. J., Chiu, W. T., & Chen, T. L. (2014). Stroke risk and outcomes in patients with traumatic brain injury: 2 nationwide studies. Mayo Clinic Proceedings, 89(2), pp. 163-72. doi:10.1016/j.mayocp.2013.09.019.
Liao CC, et al. Stroke Risk and Outcomes in Patients With Traumatic Brain Injury: 2 Nationwide Studies. Mayo Clin Proc. 2014;89(2):163-72. PubMed PMID: 24485130.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stroke risk and outcomes in patients with traumatic brain injury: 2 nationwide studies. AU - Liao,Chien-Chang, AU - Chou,Yi-Chun, AU - Yeh,Chun-Chieh, AU - Hu,Chaur-Jong, AU - Chiu,Wen-Ta, AU - Chen,Ta-Liang, PY - 2013/07/03/received PY - 2013/08/28/revised PY - 2013/09/06/accepted PY - 2014/2/4/entrez PY - 2014/2/4/pubmed PY - 2014/4/4/medline KW - COPD KW - HR KW - ICD-9-CM KW - International Classification of Diseases, Ninth Revision, Clinical Modification KW - OR KW - TBI KW - chronic obstructive pulmonary disease KW - hazard ratio KW - odds ratio KW - traumatic brain injury SP - 163 EP - 72 JF - Mayo Clinic proceedings JO - Mayo Clin. Proc. VL - 89 IS - 2 N2 - OBJECTIVE: To investigate whether patients with traumatic brain injury (TBI) have an increased risk of stroke or poststroke mortality. PARTICIPANTS AND METHODS: Using Taiwan's National Health Insurance Research Database, we conducted a retrospective cohort study of 30,165 patients with new TBI and 120,660 persons without TBI between January 1, 2000, and December 31, 2004. The risk of stroke was compared between 2 cohorts through December 31, 2008. To investigate the association between in-hospital mortality after stroke and history of TBI, we conducted a case-control study of 7751 patients with newly diagnosed stroke between January 1, 2005, and December 31, 2008. RESULTS: The TBI cohort had an increased stroke risk (hazard ratio [HR], 1.98; 95% CI, 1.86-2.11). Among patients with stroke, those with a history of TBI had a higher risk of poststroke mortality compared with those without TBI (odds ratio, 1.57; 95% CI, 1.13-2.19). In the TBI cohort, factors associated with stroke were history of TBI hospitalization (HR, 3.14; 95% CI, 2.77-3.56), emergency care for TBI (HR, 3.37; 95% CI, 2.88-3.95), brain hemorrhage (HR, 2.69; 95% CI, 2.43-2.99), skull fracture (HR, 3.00; 95% CI, 2.42-3.71), low income (HR, 2.65; 95% CI, 2.16-3.25), and high medical expenditure for TBI care (HR, 2.26; 95% CI, 2.09-2.43). The severity of TBI was also correlated with poststroke mortality. CONCLUSIONS: Traumatic brain injury was associated with risk of stroke and poststroke mortality. The relationship between TBI and poststroke mortality does not seem to transcend all age groups. This research shows the importance of prevention, early recognition, and treatment of stroke in this vulnerable population. SN - 1942-5546 UR - https://www.unboundmedicine.com/medline/citation/24485130/Stroke_risk_and_outcomes_in_patients_with_traumatic_brain_injury:_2_nationwide_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(13)00979-8 DB - PRIME DP - Unbound Medicine ER -